Deoxynivalenol induces ovarian apoptosis in peripubertal rats
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/48336 |
Resumo: | Puberty, governed by the endocrine system, marks the onset of reproductive functions in animals and humans through a series of physiological and biological transformations. Although the mycotoxin DON can disrupt hormonal balance and cause reproductive abnormalities, its impact on puberty-associated reproductive changes remains understudied. Considering the increased exposure of children and adolescents to DON, our study aimed to elucidate its influence on follicular integrity and the expression of pro-apoptotic proteins (BAX and Caspase-3) and anti-apoptotic protein (BCL-2) in juvenile rat ovarian tissue. We divided ten 28-day-old prepubertal Wistar rats into two dietary groups for 28 days: a control group with a mycotoxin-free diet and a DON group with a diet containing 10 mg DON/Kg. After the experiment, ovaries and uterus weights were recorded, and the ovaries underwent morphometric and immunohistochemical analysis. DON exposure led to significant reductions in both ovarian and uterine weights. Although DON intake did not change the number of ovarian follicles across developmental stages, we observed an increased expression of BAX and Caspase-3 and a decreased BCL-2 expression in most follicular stages and corpora lutea. In summary, DON exposure during puberty can interfere with apoptotic processes in diverse ovarian cell populations during early adulthood. |
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Semina. Ciências Agrárias (Online) |
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Deoxynivalenol induces ovarian apoptosis in peripubertal ratsDesoxinivalenol durante período pré-puberal induz apoptose em ovários de ratas imaturasApoptosisDeoxynivalenolFollicular integrityOvaryRat.ApoptoseDesoxinivalenolIntegridade folicularOvárioRatos.Puberty, governed by the endocrine system, marks the onset of reproductive functions in animals and humans through a series of physiological and biological transformations. Although the mycotoxin DON can disrupt hormonal balance and cause reproductive abnormalities, its impact on puberty-associated reproductive changes remains understudied. Considering the increased exposure of children and adolescents to DON, our study aimed to elucidate its influence on follicular integrity and the expression of pro-apoptotic proteins (BAX and Caspase-3) and anti-apoptotic protein (BCL-2) in juvenile rat ovarian tissue. We divided ten 28-day-old prepubertal Wistar rats into two dietary groups for 28 days: a control group with a mycotoxin-free diet and a DON group with a diet containing 10 mg DON/Kg. After the experiment, ovaries and uterus weights were recorded, and the ovaries underwent morphometric and immunohistochemical analysis. DON exposure led to significant reductions in both ovarian and uterine weights. Although DON intake did not change the number of ovarian follicles across developmental stages, we observed an increased expression of BAX and Caspase-3 and a decreased BCL-2 expression in most follicular stages and corpora lutea. In summary, DON exposure during puberty can interfere with apoptotic processes in diverse ovarian cell populations during early adulthood.A puberdade é um processo regulado pelo sistema endócrino em que as diversas alterações fisiológicas e biológicas são responsáveis pelo início das funções reprodutivas em animais e humanos. DON pode interferir no sistema hormonal induzindo desordens endócrinas e danos reprodutivos. Entretanto, o potencial de DON em causar danos reprodutivos no período da puberdade tem sido negligenciado. Considerando que crianças e adolescentes têm um alto risco de exposição à DON, este estudo teve como objetivo avaliar o efeito desta micotoxina durante a puberdade sobre a integridade folicular e a expressão de proteínas pró-apoptóticas (BAX e Caspase-3) e anti-apoptóticas (BCL-2) em ovários de ratos jovens. Dez ratos Wistar pré-púberes (28 dias de idade) foram utilizados. Os animais foram expostos por 28 dias às seguintes dietas: 1) controle: dieta livre de micotoxinas e 2) DON: dieta contendo 10 mg DON/Kg de alimento. Ao final, os ovários e úteros foram pesados e os ovários submetidos à análise morfométrica e imuno-histoquímica. A ingestão da dieta contaminada induziu a uma redução significativa no peso dos ovários e úteros, no entanto não houve diferença no número de folículos ovarianos em todos os estágios de desenvolvimento folicular. Um aumento significativo da expressão de BAX e Caspase-3 e uma diminuição da expressão de BCL-2 foram observados na maioria dos estágios foliculares e do corpo lúteo nos animais alimentados com DON. Em conclusão, a exposição ao DON durante o período pré-púbere induz apoptose em diferentes populações de células ovarianas e pode interferir no desenvolvimento reprodutivo de animais adultos.UEL2023-11-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/4833610.5433/1679-0359.2023v44n5p1621Semina: Ciências Agrárias; Vol. 44 No. 5 (2023); 1621-1636Semina: Ciências Agrárias; v. 44 n. 5 (2023); 1621-16361679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/48336/49624Copyright (c) 2023 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessGerez, Juliana Rubira Lemos, Gisele Augusta Amorim deCamacho, ThaynaraMarutani, Victor Hugo BrunaldiChuffa, Luiz GustavoSilveira, Henrique SpaulonciVerri , Waldiceu AparecidoGloria, Eduardo Micotti daBracarence, Ana Paula Frederico Rodrigues Loureiro2023-12-12T16:15:08Zoai:ojs.pkp.sfu.ca:article/48336Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2023-12-12T16:15:08Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Deoxynivalenol induces ovarian apoptosis in peripubertal rats Desoxinivalenol durante período pré-puberal induz apoptose em ovários de ratas imaturas |
title |
Deoxynivalenol induces ovarian apoptosis in peripubertal rats |
spellingShingle |
Deoxynivalenol induces ovarian apoptosis in peripubertal rats Gerez, Juliana Rubira Apoptosis Deoxynivalenol Follicular integrity Ovary Rat. Apoptose Desoxinivalenol Integridade folicular Ovário Ratos. |
title_short |
Deoxynivalenol induces ovarian apoptosis in peripubertal rats |
title_full |
Deoxynivalenol induces ovarian apoptosis in peripubertal rats |
title_fullStr |
Deoxynivalenol induces ovarian apoptosis in peripubertal rats |
title_full_unstemmed |
Deoxynivalenol induces ovarian apoptosis in peripubertal rats |
title_sort |
Deoxynivalenol induces ovarian apoptosis in peripubertal rats |
author |
Gerez, Juliana Rubira |
author_facet |
Gerez, Juliana Rubira Lemos, Gisele Augusta Amorim de Camacho, Thaynara Marutani, Victor Hugo Brunaldi Chuffa, Luiz Gustavo Silveira, Henrique Spaulonci Verri , Waldiceu Aparecido Gloria, Eduardo Micotti da Bracarence, Ana Paula Frederico Rodrigues Loureiro |
author_role |
author |
author2 |
Lemos, Gisele Augusta Amorim de Camacho, Thaynara Marutani, Victor Hugo Brunaldi Chuffa, Luiz Gustavo Silveira, Henrique Spaulonci Verri , Waldiceu Aparecido Gloria, Eduardo Micotti da Bracarence, Ana Paula Frederico Rodrigues Loureiro |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gerez, Juliana Rubira Lemos, Gisele Augusta Amorim de Camacho, Thaynara Marutani, Victor Hugo Brunaldi Chuffa, Luiz Gustavo Silveira, Henrique Spaulonci Verri , Waldiceu Aparecido Gloria, Eduardo Micotti da Bracarence, Ana Paula Frederico Rodrigues Loureiro |
dc.subject.por.fl_str_mv |
Apoptosis Deoxynivalenol Follicular integrity Ovary Rat. Apoptose Desoxinivalenol Integridade folicular Ovário Ratos. |
topic |
Apoptosis Deoxynivalenol Follicular integrity Ovary Rat. Apoptose Desoxinivalenol Integridade folicular Ovário Ratos. |
description |
Puberty, governed by the endocrine system, marks the onset of reproductive functions in animals and humans through a series of physiological and biological transformations. Although the mycotoxin DON can disrupt hormonal balance and cause reproductive abnormalities, its impact on puberty-associated reproductive changes remains understudied. Considering the increased exposure of children and adolescents to DON, our study aimed to elucidate its influence on follicular integrity and the expression of pro-apoptotic proteins (BAX and Caspase-3) and anti-apoptotic protein (BCL-2) in juvenile rat ovarian tissue. We divided ten 28-day-old prepubertal Wistar rats into two dietary groups for 28 days: a control group with a mycotoxin-free diet and a DON group with a diet containing 10 mg DON/Kg. After the experiment, ovaries and uterus weights were recorded, and the ovaries underwent morphometric and immunohistochemical analysis. DON exposure led to significant reductions in both ovarian and uterine weights. Although DON intake did not change the number of ovarian follicles across developmental stages, we observed an increased expression of BAX and Caspase-3 and a decreased BCL-2 expression in most follicular stages and corpora lutea. In summary, DON exposure during puberty can interfere with apoptotic processes in diverse ovarian cell populations during early adulthood. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-06 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/48336 10.5433/1679-0359.2023v44n5p1621 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/48336 |
identifier_str_mv |
10.5433/1679-0359.2023v44n5p1621 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/48336/49624 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 44 No. 5 (2023); 1621-1636 Semina: Ciências Agrárias; v. 44 n. 5 (2023); 1621-1636 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
_version_ |
1799306087188398080 |