Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40117 |
Resumo: | This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2.0 mg kg-1; GKM = ketamine 2.0 mg kg-1 + morphine 0.1 mg kg-1; GKX = ketamine 2.0 mg kg-1 + xylazine 0.05 mg kg-1) were compared among each other and with a control treatment (GS= saline 1 mL/7.5 kg). The assessed variables were heart rate, respiratory frequency, ear temperature, non-invasive blood pressure and hemogasometric analysis. All parameters were assessed at baseline and then ewes were sedated with an association of acepromazine (0.1 mg kg -1) and diazepam (0.2 mg kg -1). Ten minutes after sedation all parameters were reassessed and afterwards the epidural injections were performed. Hemogasometry was repeated at 15 and 30 minutes after epidural and the other parameters assessed at 05, 15, 30, 45 and 60 minutes after epidural. GKX showed a slight respiratory depression with lower levels of PO2 and a compensatory increase in respiratory frequency. GKM presented the lower temperature mean. All protocols showed few cardiorespiratory effects when compared with control. Epidural with 2.0 mg kg-1 ketamine isolated was considered the best option for short procedures as obstetric manipulations in sheep due to its cardiorespiratory stability when compared with the protocols using associations. |
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Semina. Ciências Agrárias (Online) |
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Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheepEfeitos cardiorrespiratórios e hemogasométricos da cetamina e suas associações com morfina e xilazina por via epidural em ovinosAnalgesiaLoco-regional anesthesiaAcid-base balance.AnalgesiaAnestesia loco-regionalEquilíbrio ácido-base.This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2.0 mg kg-1; GKM = ketamine 2.0 mg kg-1 + morphine 0.1 mg kg-1; GKX = ketamine 2.0 mg kg-1 + xylazine 0.05 mg kg-1) were compared among each other and with a control treatment (GS= saline 1 mL/7.5 kg). The assessed variables were heart rate, respiratory frequency, ear temperature, non-invasive blood pressure and hemogasometric analysis. All parameters were assessed at baseline and then ewes were sedated with an association of acepromazine (0.1 mg kg -1) and diazepam (0.2 mg kg -1). Ten minutes after sedation all parameters were reassessed and afterwards the epidural injections were performed. Hemogasometry was repeated at 15 and 30 minutes after epidural and the other parameters assessed at 05, 15, 30, 45 and 60 minutes after epidural. GKX showed a slight respiratory depression with lower levels of PO2 and a compensatory increase in respiratory frequency. GKM presented the lower temperature mean. All protocols showed few cardiorespiratory effects when compared with control. Epidural with 2.0 mg kg-1 ketamine isolated was considered the best option for short procedures as obstetric manipulations in sheep due to its cardiorespiratory stability when compared with the protocols using associations.UEL2021-01-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionCrossover; blindedapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/4011710.5433/1679-0359.2021v42n1p241Semina: Ciências Agrárias; Vol. 42 No. 1 (2021); 241-254Semina: Ciências Agrárias; v. 42 n. 1 (2021); 241-2541679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40117/28507Copyright (c) 2020 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessLeite, Ceci RibeiroAscoli, Fabio OteroOliveira, Juliana deFernandes, Daniel Andrews de MouraFonseca, Jeferson Ferreira daBrandão, Felipe Zandonadi2022-10-04T15:24:58Zoai:ojs.pkp.sfu.ca:article/40117Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-04T15:24:58Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep Efeitos cardiorrespiratórios e hemogasométricos da cetamina e suas associações com morfina e xilazina por via epidural em ovinos |
title |
Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep |
spellingShingle |
Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep Leite, Ceci Ribeiro Analgesia Loco-regional anesthesia Acid-base balance. Analgesia Anestesia loco-regional Equilíbrio ácido-base. |
title_short |
Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep |
title_full |
Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep |
title_fullStr |
Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep |
title_full_unstemmed |
Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep |
title_sort |
Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep |
author |
Leite, Ceci Ribeiro |
author_facet |
Leite, Ceci Ribeiro Ascoli, Fabio Otero Oliveira, Juliana de Fernandes, Daniel Andrews de Moura Fonseca, Jeferson Ferreira da Brandão, Felipe Zandonadi |
author_role |
author |
author2 |
Ascoli, Fabio Otero Oliveira, Juliana de Fernandes, Daniel Andrews de Moura Fonseca, Jeferson Ferreira da Brandão, Felipe Zandonadi |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Leite, Ceci Ribeiro Ascoli, Fabio Otero Oliveira, Juliana de Fernandes, Daniel Andrews de Moura Fonseca, Jeferson Ferreira da Brandão, Felipe Zandonadi |
dc.subject.por.fl_str_mv |
Analgesia Loco-regional anesthesia Acid-base balance. Analgesia Anestesia loco-regional Equilíbrio ácido-base. |
topic |
Analgesia Loco-regional anesthesia Acid-base balance. Analgesia Anestesia loco-regional Equilíbrio ácido-base. |
description |
This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2.0 mg kg-1; GKM = ketamine 2.0 mg kg-1 + morphine 0.1 mg kg-1; GKX = ketamine 2.0 mg kg-1 + xylazine 0.05 mg kg-1) were compared among each other and with a control treatment (GS= saline 1 mL/7.5 kg). The assessed variables were heart rate, respiratory frequency, ear temperature, non-invasive blood pressure and hemogasometric analysis. All parameters were assessed at baseline and then ewes were sedated with an association of acepromazine (0.1 mg kg -1) and diazepam (0.2 mg kg -1). Ten minutes after sedation all parameters were reassessed and afterwards the epidural injections were performed. Hemogasometry was repeated at 15 and 30 minutes after epidural and the other parameters assessed at 05, 15, 30, 45 and 60 minutes after epidural. GKX showed a slight respiratory depression with lower levels of PO2 and a compensatory increase in respiratory frequency. GKM presented the lower temperature mean. All protocols showed few cardiorespiratory effects when compared with control. Epidural with 2.0 mg kg-1 ketamine isolated was considered the best option for short procedures as obstetric manipulations in sheep due to its cardiorespiratory stability when compared with the protocols using associations. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-19 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Crossover; blinded |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40117 10.5433/1679-0359.2021v42n1p241 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40117 |
identifier_str_mv |
10.5433/1679-0359.2021v42n1p241 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40117/28507 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 42 No. 1 (2021); 241-254 Semina: Ciências Agrárias; v. 42 n. 1 (2021); 241-254 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
_version_ |
1799306082907062272 |