Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep

Detalhes bibliográficos
Autor(a) principal: Leite, Ceci Ribeiro
Data de Publicação: 2021
Outros Autores: Ascoli, Fabio Otero, Oliveira, Juliana de, Fernandes, Daniel Andrews de Moura, Fonseca, Jeferson Ferreira da, Brandão, Felipe Zandonadi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Semina. Ciências Agrárias (Online)
Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40117
Resumo: This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2.0 mg kg-1; GKM = ketamine 2.0 mg kg-1 + morphine 0.1 mg kg-1; GKX = ketamine 2.0 mg kg-1 + xylazine 0.05 mg kg-1) were compared among each other and with a control treatment (GS= saline 1 mL/7.5 kg). The assessed variables were heart rate, respiratory frequency, ear temperature, non-invasive blood pressure and hemogasometric analysis. All parameters were assessed at baseline and then ewes were sedated with an association of acepromazine (0.1 mg kg -1) and diazepam (0.2 mg kg -1). Ten minutes after sedation all parameters were reassessed and afterwards the epidural injections were performed. Hemogasometry was repeated at 15 and 30 minutes after epidural and the other parameters assessed at 05, 15, 30, 45 and 60 minutes after epidural. GKX showed a slight respiratory depression with lower levels of PO2 and a compensatory increase in respiratory frequency. GKM presented the lower temperature mean. All protocols showed few cardiorespiratory effects when compared with control. Epidural with 2.0 mg kg-1 ketamine isolated was considered the best option for short procedures as obstetric manipulations in sheep due to its cardiorespiratory stability when compared with the protocols using associations.
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spelling Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheepEfeitos cardiorrespiratórios e hemogasométricos da cetamina e suas associações com morfina e xilazina por via epidural em ovinosAnalgesiaLoco-regional anesthesiaAcid-base balance.AnalgesiaAnestesia loco-regionalEquilíbrio ácido-base.This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2.0 mg kg-1; GKM = ketamine 2.0 mg kg-1 + morphine 0.1 mg kg-1; GKX = ketamine 2.0 mg kg-1 + xylazine 0.05 mg kg-1) were compared among each other and with a control treatment (GS= saline 1 mL/7.5 kg). The assessed variables were heart rate, respiratory frequency, ear temperature, non-invasive blood pressure and hemogasometric analysis. All parameters were assessed at baseline and then ewes were sedated with an association of acepromazine (0.1 mg kg -1) and diazepam (0.2 mg kg -1). Ten minutes after sedation all parameters were reassessed and afterwards the epidural injections were performed. Hemogasometry was repeated at 15 and 30 minutes after epidural and the other parameters assessed at 05, 15, 30, 45 and 60 minutes after epidural. GKX showed a slight respiratory depression with lower levels of PO2 and a compensatory increase in respiratory frequency. GKM presented the lower temperature mean. All protocols showed few cardiorespiratory effects when compared with control. Epidural with 2.0 mg kg-1 ketamine isolated was considered the best option for short procedures as obstetric manipulations in sheep due to its cardiorespiratory stability when compared with the protocols using associations.UEL2021-01-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionCrossover; blindedapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/4011710.5433/1679-0359.2021v42n1p241Semina: Ciências Agrárias; Vol. 42 No. 1 (2021); 241-254Semina: Ciências Agrárias; v. 42 n. 1 (2021); 241-2541679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40117/28507Copyright (c) 2020 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessLeite, Ceci RibeiroAscoli, Fabio OteroOliveira, Juliana deFernandes, Daniel Andrews de MouraFonseca, Jeferson Ferreira daBrandão, Felipe Zandonadi2022-10-04T15:24:58Zoai:ojs.pkp.sfu.ca:article/40117Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-04T15:24:58Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep
Efeitos cardiorrespiratórios e hemogasométricos da cetamina e suas associações com morfina e xilazina por via epidural em ovinos
title Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep
spellingShingle Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep
Leite, Ceci Ribeiro
Analgesia
Loco-regional anesthesia
Acid-base balance.
Analgesia
Anestesia loco-regional
Equilíbrio ácido-base.
title_short Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep
title_full Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep
title_fullStr Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep
title_full_unstemmed Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep
title_sort Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep
author Leite, Ceci Ribeiro
author_facet Leite, Ceci Ribeiro
Ascoli, Fabio Otero
Oliveira, Juliana de
Fernandes, Daniel Andrews de Moura
Fonseca, Jeferson Ferreira da
Brandão, Felipe Zandonadi
author_role author
author2 Ascoli, Fabio Otero
Oliveira, Juliana de
Fernandes, Daniel Andrews de Moura
Fonseca, Jeferson Ferreira da
Brandão, Felipe Zandonadi
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Leite, Ceci Ribeiro
Ascoli, Fabio Otero
Oliveira, Juliana de
Fernandes, Daniel Andrews de Moura
Fonseca, Jeferson Ferreira da
Brandão, Felipe Zandonadi
dc.subject.por.fl_str_mv Analgesia
Loco-regional anesthesia
Acid-base balance.
Analgesia
Anestesia loco-regional
Equilíbrio ácido-base.
topic Analgesia
Loco-regional anesthesia
Acid-base balance.
Analgesia
Anestesia loco-regional
Equilíbrio ácido-base.
description This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2.0 mg kg-1; GKM = ketamine 2.0 mg kg-1 + morphine 0.1 mg kg-1; GKX = ketamine 2.0 mg kg-1 + xylazine 0.05 mg kg-1) were compared among each other and with a control treatment (GS= saline 1 mL/7.5 kg). The assessed variables were heart rate, respiratory frequency, ear temperature, non-invasive blood pressure and hemogasometric analysis. All parameters were assessed at baseline and then ewes were sedated with an association of acepromazine (0.1 mg kg -1) and diazepam (0.2 mg kg -1). Ten minutes after sedation all parameters were reassessed and afterwards the epidural injections were performed. Hemogasometry was repeated at 15 and 30 minutes after epidural and the other parameters assessed at 05, 15, 30, 45 and 60 minutes after epidural. GKX showed a slight respiratory depression with lower levels of PO2 and a compensatory increase in respiratory frequency. GKM presented the lower temperature mean. All protocols showed few cardiorespiratory effects when compared with control. Epidural with 2.0 mg kg-1 ketamine isolated was considered the best option for short procedures as obstetric manipulations in sheep due to its cardiorespiratory stability when compared with the protocols using associations.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-19
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Crossover; blinded
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40117
10.5433/1679-0359.2021v42n1p241
url https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40117
identifier_str_mv 10.5433/1679-0359.2021v42n1p241
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40117/28507
dc.rights.driver.fl_str_mv Copyright (c) 2020 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UEL
publisher.none.fl_str_mv UEL
dc.source.none.fl_str_mv Semina: Ciências Agrárias; Vol. 42 No. 1 (2021); 241-254
Semina: Ciências Agrárias; v. 42 n. 1 (2021); 241-254
1679-0359
1676-546X
reponame:Semina. Ciências Agrárias (Online)
instname:Universidade Estadual de Londrina (UEL)
instacron:UEL
instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Semina. Ciências Agrárias (Online)
collection Semina. Ciências Agrárias (Online)
repository.name.fl_str_mv Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv semina.agrarias@uel.br
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