Effect of Flunixin Meglumine administration on seminal characteristics of male sheep and goat
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/28842 |
Resumo: | Testicular degeneration is a multifactorial process increasing the concentration of prostaglandins in seminal plasma. Both increase and decrease of these hormones tend to promote loss of seminal quality. Flunixin meglumine is a potent anti-inflammatory drug capable of modulating the production of prostaglandins and is widely used in female reproduction. However, it is rarely used in males with the same objective. Therefore, this study aimed to evaluate the effects of this drug on seminal quality of male lambs and goats with spermatic characteristics unfavorable for reproduction. To this end, a total of 15 breeding animals were evaluated, of which six goats and four sheep with poor seminal quality were selected according to the criteria established by the Brazilian College of Animal Reproduction (CBRA). Three semen samples were collected from each animal. Then, the flunixin meglumine treatment was initiated and ejaculates were collected at two different periods after the drug was administered (from day 21 until day 35 and from day 49 to day 63). Macroscopic and microscopic parameters were assessed in semen samples and scrotal circumference and percentages of sperm pathologies were measured and compared between the three periods. Data with normal distribution were analyzed using ANOVA at 5% probability, and comparisons between periods within the same species were performed using the Tukey test. An improvement was observed in the analyses of mass motility, percentage motility, and sperm vigor. Scrotal circumference had no variation. Concerning sperm pathologies, an increase in the number of normal spermatozoids was observed due to a significant reduction in minor and major defects, and the latter remained low even after the treatment was finished. Therefore, flunixin meglumine presented beneficial effects on seminal parameters of male goats and lamb with unfavorable spermatic characteristics. These findings indicate this drug may be used in the treating of males with testicular injuries or of breeders with reduced seminal quality due to advanced age. |
id |
UEL-11_cd269d599d47000db2df3f45954de548 |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/28842 |
network_acronym_str |
UEL-11 |
network_name_str |
Semina. Ciências Agrárias (Online) |
repository_id_str |
|
spelling |
Effect of Flunixin Meglumine administration on seminal characteristics of male sheep and goatEfeito da administração de Flunixina Meglumine sobre as características seminais de machos ovinos e caprinosAndrologyAnimal ReproductionProstaglandinsSeminal Quality.AndrologiaProstaglandinasQualidade SeminalReprodução Animal.Testicular degeneration is a multifactorial process increasing the concentration of prostaglandins in seminal plasma. Both increase and decrease of these hormones tend to promote loss of seminal quality. Flunixin meglumine is a potent anti-inflammatory drug capable of modulating the production of prostaglandins and is widely used in female reproduction. However, it is rarely used in males with the same objective. Therefore, this study aimed to evaluate the effects of this drug on seminal quality of male lambs and goats with spermatic characteristics unfavorable for reproduction. To this end, a total of 15 breeding animals were evaluated, of which six goats and four sheep with poor seminal quality were selected according to the criteria established by the Brazilian College of Animal Reproduction (CBRA). Three semen samples were collected from each animal. Then, the flunixin meglumine treatment was initiated and ejaculates were collected at two different periods after the drug was administered (from day 21 until day 35 and from day 49 to day 63). Macroscopic and microscopic parameters were assessed in semen samples and scrotal circumference and percentages of sperm pathologies were measured and compared between the three periods. Data with normal distribution were analyzed using ANOVA at 5% probability, and comparisons between periods within the same species were performed using the Tukey test. An improvement was observed in the analyses of mass motility, percentage motility, and sperm vigor. Scrotal circumference had no variation. Concerning sperm pathologies, an increase in the number of normal spermatozoids was observed due to a significant reduction in minor and major defects, and the latter remained low even after the treatment was finished. Therefore, flunixin meglumine presented beneficial effects on seminal parameters of male goats and lamb with unfavorable spermatic characteristics. These findings indicate this drug may be used in the treating of males with testicular injuries or of breeders with reduced seminal quality due to advanced age.A degeneração testicular é um processo multifatorial que leva ao aumento das prostaglandinas no plasma do ejaculado, sendo que tanto seu acréscimo quanto a redução baixam a qualidade seminal. A Flunixina Meglumine é um potente anti-inflamatório, capaz de modular a produção de prostaglandinas, amplamente difundido na reprodução de fêmeas, mas pouco utilizado em machos para esse fim. Por isso, esse trabalho buscou avaliar o efeito deste fármaco sobre a qualidade seminal de machos ovinos e caprinos que apresentem quadro espermático desfavorável à reprodução. Para tanto, um total de 15 reprodutores pertencentes à Universidade Federal do Ceará foram avaliados, dos quais foram selecionados seis bodes e quatro carneiros com sêmen de baixa qualidade, segundo os critérios do Colégio Brasileiro de Reprodução Animal (CBRA). Foram realizadas três colheitas prévias de cada animal, aplicado o tratamento com Flunixina Meglumine e, em seguida, foram colhidos ejaculados de dois momentos posteriores à aplicação do fármaco (do D21 ao D35 e do D49 ao D63). Os parâmetros espermáticos de natureza macro e microscópica, assim como a circunferência escrotal e o percentual de patologias espermáticas foram comparados entre os três momentos e os dados de distribuição normal foram avaliados por ANOVA a 5% de probabilidade e as comparações entre os momentos dentro de cada espécie quando significativa foram feitas pelo teste de Tukey. Houve melhora na motilidade massal, motilidade percentual e vigor espermático. Não ocorreu variação da circunferência escrotal e, no tocante às patologias espermáticas, observou-se um aumento no número de espermatozoides normais, devido a uma redução significativa de defeitos menores e maiores, sendo que estes permaneceram menores mesmo após cessar a influência do tratamento. Assim, a Flunixina Meglumine mostrou uma ação benéfica sobre os parâmetros seminais de machos ovinos e caprinos com quadro espermático desfavorável, sugerindo a indicação do fármaco para o tratamento de machos que passaram por injúrias testiculares diversas ou reprodutores com declínio da qualidade seminal devido à idade avançada.UEL2017-10-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigo Científicoapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2884210.5433/1679-0359.2017v38n5p3145Semina: Ciências Agrárias; Vol. 38 No. 5 (2017); 3145-3154Semina: Ciências Agrárias; v. 38 n. 5 (2017); 3145-31541679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/28842/21817Copyright (c) 2017 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessVieira Neto, Maurício FranciscoRodrigues, Inti Campos SallesLeles, Jaqueline da SilvaAraújo, Érica Pinto deViana Neto, Aderson MartinsCarvalho, Felipe Viana deSalles, Maria Gorete FloresAraújo, Airton Alencar de2022-10-21T14:18:39Zoai:ojs.pkp.sfu.ca:article/28842Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-21T14:18:39Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Effect of Flunixin Meglumine administration on seminal characteristics of male sheep and goat Efeito da administração de Flunixina Meglumine sobre as características seminais de machos ovinos e caprinos |
title |
Effect of Flunixin Meglumine administration on seminal characteristics of male sheep and goat |
spellingShingle |
Effect of Flunixin Meglumine administration on seminal characteristics of male sheep and goat Vieira Neto, Maurício Francisco Andrology Animal Reproduction Prostaglandins Seminal Quality. Andrologia Prostaglandinas Qualidade Seminal Reprodução Animal. |
title_short |
Effect of Flunixin Meglumine administration on seminal characteristics of male sheep and goat |
title_full |
Effect of Flunixin Meglumine administration on seminal characteristics of male sheep and goat |
title_fullStr |
Effect of Flunixin Meglumine administration on seminal characteristics of male sheep and goat |
title_full_unstemmed |
Effect of Flunixin Meglumine administration on seminal characteristics of male sheep and goat |
title_sort |
Effect of Flunixin Meglumine administration on seminal characteristics of male sheep and goat |
author |
Vieira Neto, Maurício Francisco |
author_facet |
Vieira Neto, Maurício Francisco Rodrigues, Inti Campos Salles Leles, Jaqueline da Silva Araújo, Érica Pinto de Viana Neto, Aderson Martins Carvalho, Felipe Viana de Salles, Maria Gorete Flores Araújo, Airton Alencar de |
author_role |
author |
author2 |
Rodrigues, Inti Campos Salles Leles, Jaqueline da Silva Araújo, Érica Pinto de Viana Neto, Aderson Martins Carvalho, Felipe Viana de Salles, Maria Gorete Flores Araújo, Airton Alencar de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Vieira Neto, Maurício Francisco Rodrigues, Inti Campos Salles Leles, Jaqueline da Silva Araújo, Érica Pinto de Viana Neto, Aderson Martins Carvalho, Felipe Viana de Salles, Maria Gorete Flores Araújo, Airton Alencar de |
dc.subject.por.fl_str_mv |
Andrology Animal Reproduction Prostaglandins Seminal Quality. Andrologia Prostaglandinas Qualidade Seminal Reprodução Animal. |
topic |
Andrology Animal Reproduction Prostaglandins Seminal Quality. Andrologia Prostaglandinas Qualidade Seminal Reprodução Animal. |
description |
Testicular degeneration is a multifactorial process increasing the concentration of prostaglandins in seminal plasma. Both increase and decrease of these hormones tend to promote loss of seminal quality. Flunixin meglumine is a potent anti-inflammatory drug capable of modulating the production of prostaglandins and is widely used in female reproduction. However, it is rarely used in males with the same objective. Therefore, this study aimed to evaluate the effects of this drug on seminal quality of male lambs and goats with spermatic characteristics unfavorable for reproduction. To this end, a total of 15 breeding animals were evaluated, of which six goats and four sheep with poor seminal quality were selected according to the criteria established by the Brazilian College of Animal Reproduction (CBRA). Three semen samples were collected from each animal. Then, the flunixin meglumine treatment was initiated and ejaculates were collected at two different periods after the drug was administered (from day 21 until day 35 and from day 49 to day 63). Macroscopic and microscopic parameters were assessed in semen samples and scrotal circumference and percentages of sperm pathologies were measured and compared between the three periods. Data with normal distribution were analyzed using ANOVA at 5% probability, and comparisons between periods within the same species were performed using the Tukey test. An improvement was observed in the analyses of mass motility, percentage motility, and sperm vigor. Scrotal circumference had no variation. Concerning sperm pathologies, an increase in the number of normal spermatozoids was observed due to a significant reduction in minor and major defects, and the latter remained low even after the treatment was finished. Therefore, flunixin meglumine presented beneficial effects on seminal parameters of male goats and lamb with unfavorable spermatic characteristics. These findings indicate this drug may be used in the treating of males with testicular injuries or of breeders with reduced seminal quality due to advanced age. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-03 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo Científico |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/28842 10.5433/1679-0359.2017v38n5p3145 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/28842 |
identifier_str_mv |
10.5433/1679-0359.2017v38n5p3145 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/28842/21817 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 38 No. 5 (2017); 3145-3154 Semina: Ciências Agrárias; v. 38 n. 5 (2017); 3145-3154 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
_version_ |
1799306077654745088 |