Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus

Detalhes bibliográficos
Autor(a) principal: Portella, Luiza Pires
Data de Publicação: 2021
Outros Autores: Fernandes, Fagner D'ambroso, Sangioni, Luís Antônio, Ramos, Fernanda, Rodrigues, Fernando de Souza, Menezes, Fernanda Rezer de, Cezar, Alfredo Skrebsky, Faccin, Tatiane Cargnin, Kommers, Glaucia Denise, Vogel, Fernanda Silveira Flores
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Semina. Ciências Agrárias (Online)
Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40310
Resumo: Considering the importance of Haemonchus contortus infection in herds along with parasitic resistance, the goal of this study was to evaluate the influence of the administration of adjuvants alone or in combination with anthelmintics for the treatment of H. contortus, in experimentally infected sheep. Thirty sheep of the Texel breed of both genders, raised in a herd located in the subtropical region of Brazil, were used in this experiment. Experimental infection with H. contortus was performed in sheep, and the infected sheep were then separated into groups for the administration of antiparasitic and immunostimulant drugs. The results obtained from the excretion of eggs per gram of feces and the count of parasites during necropsy affirm that the use of adjuvants in combination with anthelmintics is associated with higher efficacy of treatment, lower rate of reinfection, and retardation in the development of anthelmintic drug resistance by H. contortus. Based on these results, we can conclude that the combination of anthelmintics and immunostimulants may favor potential anthelmintic treatments for H. contortus.
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spelling Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortusAssociação de imunoestimulantes com anti-helmínticos no tratamento de animais experimentalmente infectados com Haemonchus contortusInfectionTreatmentAdjuvantsAnthelmintics.InfecçãoTratamentoAdjuvantesAnti-helmínticos.Considering the importance of Haemonchus contortus infection in herds along with parasitic resistance, the goal of this study was to evaluate the influence of the administration of adjuvants alone or in combination with anthelmintics for the treatment of H. contortus, in experimentally infected sheep. Thirty sheep of the Texel breed of both genders, raised in a herd located in the subtropical region of Brazil, were used in this experiment. Experimental infection with H. contortus was performed in sheep, and the infected sheep were then separated into groups for the administration of antiparasitic and immunostimulant drugs. The results obtained from the excretion of eggs per gram of feces and the count of parasites during necropsy affirm that the use of adjuvants in combination with anthelmintics is associated with higher efficacy of treatment, lower rate of reinfection, and retardation in the development of anthelmintic drug resistance by H. contortus. Based on these results, we can conclude that the combination of anthelmintics and immunostimulants may favor potential anthelmintic treatments for H. contortus.Considerando a importância da infecção por Haemonchus contortus em rebanhos juntamente com a resistência parasitária, o objetivo deste estudo foi avaliar a influência da administração de adjuvantes isolados ou em combinação com o tratamento anti-helmíntico no tratamento de H. contortus em ovinos infectados experimentalmente. Foram utilizados trinta ovinos da raça Texel, de ambos os sexos criados em um rebanho localizado na região subtropical do Brasil, foram utilizados no experimento. A infecção experimental por H. contortus foi realizada em ovinos, separados em grupos para administração de medicamentos antiparasitários e imunoestimulantes. Os resultados obtidos da excreção de ovos por grama de fezes e da contagem de parasitas durante a necropsia afirmam que o uso de adjuvantes em combinação com anti-helmínticos está associado a maior eficácia do tratamento, menor taxa de reinfecção e retardo do processo de desenvolvimento de resistência anti-helmíntica por H. contortus. Com base nesses resultados, podemos concluir que a combinação de anti-helmínticos e imunoestimulantes podem favorecer potenciais tratamentos anti-helmínticos para H. contortus.UEL2021-02-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/4031010.5433/1679-0359.2021v42n2p707Semina: Ciências Agrárias; Vol. 42 No. 2 (2021); 707-720Semina: Ciências Agrárias; v. 42 n. 2 (2021); 707-7201679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40310/29030Copyright (c) 2021 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessPortella, Luiza PiresFernandes, Fagner D'ambrosoSangioni, Luís AntônioRamos, FernandaRodrigues, Fernando de SouzaMenezes, Fernanda Rezer deCezar, Alfredo SkrebskyFaccin, Tatiane CargninKommers, Glaucia DeniseVogel, Fernanda Silveira Flores2022-10-04T14:03:55Zoai:ojs.pkp.sfu.ca:article/40310Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-04T14:03:55Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus
Associação de imunoestimulantes com anti-helmínticos no tratamento de animais experimentalmente infectados com Haemonchus contortus
title Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus
spellingShingle Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus
Portella, Luiza Pires
Infection
Treatment
Adjuvants
Anthelmintics.
Infecção
Tratamento
Adjuvantes
Anti-helmínticos.
title_short Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus
title_full Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus
title_fullStr Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus
title_full_unstemmed Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus
title_sort Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus
author Portella, Luiza Pires
author_facet Portella, Luiza Pires
Fernandes, Fagner D'ambroso
Sangioni, Luís Antônio
Ramos, Fernanda
Rodrigues, Fernando de Souza
Menezes, Fernanda Rezer de
Cezar, Alfredo Skrebsky
Faccin, Tatiane Cargnin
Kommers, Glaucia Denise
Vogel, Fernanda Silveira Flores
author_role author
author2 Fernandes, Fagner D'ambroso
Sangioni, Luís Antônio
Ramos, Fernanda
Rodrigues, Fernando de Souza
Menezes, Fernanda Rezer de
Cezar, Alfredo Skrebsky
Faccin, Tatiane Cargnin
Kommers, Glaucia Denise
Vogel, Fernanda Silveira Flores
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Portella, Luiza Pires
Fernandes, Fagner D'ambroso
Sangioni, Luís Antônio
Ramos, Fernanda
Rodrigues, Fernando de Souza
Menezes, Fernanda Rezer de
Cezar, Alfredo Skrebsky
Faccin, Tatiane Cargnin
Kommers, Glaucia Denise
Vogel, Fernanda Silveira Flores
dc.subject.por.fl_str_mv Infection
Treatment
Adjuvants
Anthelmintics.
Infecção
Tratamento
Adjuvantes
Anti-helmínticos.
topic Infection
Treatment
Adjuvants
Anthelmintics.
Infecção
Tratamento
Adjuvantes
Anti-helmínticos.
description Considering the importance of Haemonchus contortus infection in herds along with parasitic resistance, the goal of this study was to evaluate the influence of the administration of adjuvants alone or in combination with anthelmintics for the treatment of H. contortus, in experimentally infected sheep. Thirty sheep of the Texel breed of both genders, raised in a herd located in the subtropical region of Brazil, were used in this experiment. Experimental infection with H. contortus was performed in sheep, and the infected sheep were then separated into groups for the administration of antiparasitic and immunostimulant drugs. The results obtained from the excretion of eggs per gram of feces and the count of parasites during necropsy affirm that the use of adjuvants in combination with anthelmintics is associated with higher efficacy of treatment, lower rate of reinfection, and retardation in the development of anthelmintic drug resistance by H. contortus. Based on these results, we can conclude that the combination of anthelmintics and immunostimulants may favor potential anthelmintic treatments for H. contortus.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-24
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40310
10.5433/1679-0359.2021v42n2p707
url https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40310
identifier_str_mv 10.5433/1679-0359.2021v42n2p707
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40310/29030
dc.rights.driver.fl_str_mv Copyright (c) 2021 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UEL
publisher.none.fl_str_mv UEL
dc.source.none.fl_str_mv Semina: Ciências Agrárias; Vol. 42 No. 2 (2021); 707-720
Semina: Ciências Agrárias; v. 42 n. 2 (2021); 707-720
1679-0359
1676-546X
reponame:Semina. Ciências Agrárias (Online)
instname:Universidade Estadual de Londrina (UEL)
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instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Semina. Ciências Agrárias (Online)
collection Semina. Ciências Agrárias (Online)
repository.name.fl_str_mv Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv semina.agrarias@uel.br
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