DNA vaccines: general concerns and its applications in human and veterinary medicine

Detalhes bibliográficos
Autor(a) principal: Kano, Flora Satiko
Data de Publicação: 2007
Outros Autores: Vidotto, Odilon, Vidotto, Marilda Carlos
Tipo de documento: Artigo
Idioma: por
Título da fonte: Semina. Ciências Agrárias (Online)
Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2925
Resumo: The vaccination with DNA is one of the most promising immunization techniques against a pathogens variety and tumors, for which the conventional methods have not been efficient. DNA vaccines are capable to induce immune humoral and cellular response, directed to lymphocytes CD4+ and CD8+, without the necessity of live microorganisms. In spite of the great potential of inducing protective immunity, the DNA vaccine not always has success. The immunity depends on several factors such as the selection of the target gene, construction of the expression vector, frequency and via of administration of the vaccine, amount of DNA, location of the antigen codified by the plasmid and age, health and species of vaccinated animals. This revision shows the development of some vaccines of DNA for diseases of interest in the veterinary and human medicine.
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spelling DNA vaccines: general concerns and its applications in human and veterinary medicineVacina de DNA: aspectos gerais e sua aplicação na medicina humana e veterináriaAnaplasma marginaleDNA vaccineCattleHumoral responseCellular response.Anaplasma marginaleVacina de DNABovinosResposta humoralResposta celular.The vaccination with DNA is one of the most promising immunization techniques against a pathogens variety and tumors, for which the conventional methods have not been efficient. DNA vaccines are capable to induce immune humoral and cellular response, directed to lymphocytes CD4+ and CD8+, without the necessity of live microorganisms. In spite of the great potential of inducing protective immunity, the DNA vaccine not always has success. The immunity depends on several factors such as the selection of the target gene, construction of the expression vector, frequency and via of administration of the vaccine, amount of DNA, location of the antigen codified by the plasmid and age, health and species of vaccinated animals. This revision shows the development of some vaccines of DNA for diseases of interest in the veterinary and human medicine.A vacinação com DNA é uma das mais promissoras técnicas de imunização contra uma variedade de patógenos e tumores, para os quais os métodos convencionais não tem sido eficientes. Vacinas de DNA são capazes de induzir resposta imune humoral e celular, tanto para resposta de linfócitos CD4+ quanto CD8+, sem a necessidade de microrganismos vivos. Apesar do grande potencial de induzir imunidade protetora, a vacina de DNA nem sempre apresenta bons resultados. A imunidade depende de vários fatores como a seleção do gene alvo, construção do vetor de expressão, freqüência e via de administração da vacina, quantidade de DNA, localização do antígeno codificado pelo plasmídio e idade, saúde e espécies de animais vacinados. Esta revisão relata o desenvolvimento de algumas vacinas de DNA para doenças de interesse na medicina veterinária e humana.UEL2007-08-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/292510.5433/1679-0359.2007v28n4p709Semina: Ciências Agrárias; Vol. 28 No. 4 (2007); 709-726Semina: Ciências Agrárias; v. 28 n. 4 (2007); 709-7261679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELporhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2925/2482Kano, Flora SatikoVidotto, OdilonVidotto, Marilda Carlosinfo:eu-repo/semantics/openAccess2015-11-19T18:38:56Zoai:ojs.pkp.sfu.ca:article/2925Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2015-11-19T18:38:56Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv DNA vaccines: general concerns and its applications in human and veterinary medicine
Vacina de DNA: aspectos gerais e sua aplicação na medicina humana e veterinária
title DNA vaccines: general concerns and its applications in human and veterinary medicine
spellingShingle DNA vaccines: general concerns and its applications in human and veterinary medicine
Kano, Flora Satiko
Anaplasma marginale
DNA vaccine
Cattle
Humoral response
Cellular response.
Anaplasma marginale
Vacina de DNA
Bovinos
Resposta humoral
Resposta celular.
title_short DNA vaccines: general concerns and its applications in human and veterinary medicine
title_full DNA vaccines: general concerns and its applications in human and veterinary medicine
title_fullStr DNA vaccines: general concerns and its applications in human and veterinary medicine
title_full_unstemmed DNA vaccines: general concerns and its applications in human and veterinary medicine
title_sort DNA vaccines: general concerns and its applications in human and veterinary medicine
author Kano, Flora Satiko
author_facet Kano, Flora Satiko
Vidotto, Odilon
Vidotto, Marilda Carlos
author_role author
author2 Vidotto, Odilon
Vidotto, Marilda Carlos
author2_role author
author
dc.contributor.author.fl_str_mv Kano, Flora Satiko
Vidotto, Odilon
Vidotto, Marilda Carlos
dc.subject.por.fl_str_mv Anaplasma marginale
DNA vaccine
Cattle
Humoral response
Cellular response.
Anaplasma marginale
Vacina de DNA
Bovinos
Resposta humoral
Resposta celular.
topic Anaplasma marginale
DNA vaccine
Cattle
Humoral response
Cellular response.
Anaplasma marginale
Vacina de DNA
Bovinos
Resposta humoral
Resposta celular.
description The vaccination with DNA is one of the most promising immunization techniques against a pathogens variety and tumors, for which the conventional methods have not been efficient. DNA vaccines are capable to induce immune humoral and cellular response, directed to lymphocytes CD4+ and CD8+, without the necessity of live microorganisms. In spite of the great potential of inducing protective immunity, the DNA vaccine not always has success. The immunity depends on several factors such as the selection of the target gene, construction of the expression vector, frequency and via of administration of the vaccine, amount of DNA, location of the antigen codified by the plasmid and age, health and species of vaccinated animals. This revision shows the development of some vaccines of DNA for diseases of interest in the veterinary and human medicine.
publishDate 2007
dc.date.none.fl_str_mv 2007-08-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2925
10.5433/1679-0359.2007v28n4p709
url https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2925
identifier_str_mv 10.5433/1679-0359.2007v28n4p709
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2925/2482
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UEL
publisher.none.fl_str_mv UEL
dc.source.none.fl_str_mv Semina: Ciências Agrárias; Vol. 28 No. 4 (2007); 709-726
Semina: Ciências Agrárias; v. 28 n. 4 (2007); 709-726
1679-0359
1676-546X
reponame:Semina. Ciências Agrárias (Online)
instname:Universidade Estadual de Londrina (UEL)
instacron:UEL
instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Semina. Ciências Agrárias (Online)
collection Semina. Ciências Agrárias (Online)
repository.name.fl_str_mv Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv semina.agrarias@uel.br
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