DNA vaccines: general concerns and its applications in human and veterinary medicine
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2925 |
Resumo: | The vaccination with DNA is one of the most promising immunization techniques against a pathogens variety and tumors, for which the conventional methods have not been efficient. DNA vaccines are capable to induce immune humoral and cellular response, directed to lymphocytes CD4+ and CD8+, without the necessity of live microorganisms. In spite of the great potential of inducing protective immunity, the DNA vaccine not always has success. The immunity depends on several factors such as the selection of the target gene, construction of the expression vector, frequency and via of administration of the vaccine, amount of DNA, location of the antigen codified by the plasmid and age, health and species of vaccinated animals. This revision shows the development of some vaccines of DNA for diseases of interest in the veterinary and human medicine. |
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Semina. Ciências Agrárias (Online) |
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DNA vaccines: general concerns and its applications in human and veterinary medicineVacina de DNA: aspectos gerais e sua aplicação na medicina humana e veterináriaAnaplasma marginaleDNA vaccineCattleHumoral responseCellular response.Anaplasma marginaleVacina de DNABovinosResposta humoralResposta celular.The vaccination with DNA is one of the most promising immunization techniques against a pathogens variety and tumors, for which the conventional methods have not been efficient. DNA vaccines are capable to induce immune humoral and cellular response, directed to lymphocytes CD4+ and CD8+, without the necessity of live microorganisms. In spite of the great potential of inducing protective immunity, the DNA vaccine not always has success. The immunity depends on several factors such as the selection of the target gene, construction of the expression vector, frequency and via of administration of the vaccine, amount of DNA, location of the antigen codified by the plasmid and age, health and species of vaccinated animals. This revision shows the development of some vaccines of DNA for diseases of interest in the veterinary and human medicine.A vacinação com DNA é uma das mais promissoras técnicas de imunização contra uma variedade de patógenos e tumores, para os quais os métodos convencionais não tem sido eficientes. Vacinas de DNA são capazes de induzir resposta imune humoral e celular, tanto para resposta de linfócitos CD4+ quanto CD8+, sem a necessidade de microrganismos vivos. Apesar do grande potencial de induzir imunidade protetora, a vacina de DNA nem sempre apresenta bons resultados. A imunidade depende de vários fatores como a seleção do gene alvo, construção do vetor de expressão, freqüência e via de administração da vacina, quantidade de DNA, localização do antígeno codificado pelo plasmídio e idade, saúde e espécies de animais vacinados. Esta revisão relata o desenvolvimento de algumas vacinas de DNA para doenças de interesse na medicina veterinária e humana.UEL2007-08-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/292510.5433/1679-0359.2007v28n4p709Semina: Ciências Agrárias; Vol. 28 No. 4 (2007); 709-726Semina: Ciências Agrárias; v. 28 n. 4 (2007); 709-7261679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELporhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2925/2482Kano, Flora SatikoVidotto, OdilonVidotto, Marilda Carlosinfo:eu-repo/semantics/openAccess2015-11-19T18:38:56Zoai:ojs.pkp.sfu.ca:article/2925Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2015-11-19T18:38:56Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
DNA vaccines: general concerns and its applications in human and veterinary medicine Vacina de DNA: aspectos gerais e sua aplicação na medicina humana e veterinária |
title |
DNA vaccines: general concerns and its applications in human and veterinary medicine |
spellingShingle |
DNA vaccines: general concerns and its applications in human and veterinary medicine Kano, Flora Satiko Anaplasma marginale DNA vaccine Cattle Humoral response Cellular response. Anaplasma marginale Vacina de DNA Bovinos Resposta humoral Resposta celular. |
title_short |
DNA vaccines: general concerns and its applications in human and veterinary medicine |
title_full |
DNA vaccines: general concerns and its applications in human and veterinary medicine |
title_fullStr |
DNA vaccines: general concerns and its applications in human and veterinary medicine |
title_full_unstemmed |
DNA vaccines: general concerns and its applications in human and veterinary medicine |
title_sort |
DNA vaccines: general concerns and its applications in human and veterinary medicine |
author |
Kano, Flora Satiko |
author_facet |
Kano, Flora Satiko Vidotto, Odilon Vidotto, Marilda Carlos |
author_role |
author |
author2 |
Vidotto, Odilon Vidotto, Marilda Carlos |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Kano, Flora Satiko Vidotto, Odilon Vidotto, Marilda Carlos |
dc.subject.por.fl_str_mv |
Anaplasma marginale DNA vaccine Cattle Humoral response Cellular response. Anaplasma marginale Vacina de DNA Bovinos Resposta humoral Resposta celular. |
topic |
Anaplasma marginale DNA vaccine Cattle Humoral response Cellular response. Anaplasma marginale Vacina de DNA Bovinos Resposta humoral Resposta celular. |
description |
The vaccination with DNA is one of the most promising immunization techniques against a pathogens variety and tumors, for which the conventional methods have not been efficient. DNA vaccines are capable to induce immune humoral and cellular response, directed to lymphocytes CD4+ and CD8+, without the necessity of live microorganisms. In spite of the great potential of inducing protective immunity, the DNA vaccine not always has success. The immunity depends on several factors such as the selection of the target gene, construction of the expression vector, frequency and via of administration of the vaccine, amount of DNA, location of the antigen codified by the plasmid and age, health and species of vaccinated animals. This revision shows the development of some vaccines of DNA for diseases of interest in the veterinary and human medicine. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-08-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2925 10.5433/1679-0359.2007v28n4p709 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2925 |
identifier_str_mv |
10.5433/1679-0359.2007v28n4p709 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2925/2482 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 28 No. 4 (2007); 709-726 Semina: Ciências Agrárias; v. 28 n. 4 (2007); 709-726 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
_version_ |
1799306059291033600 |