Theoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonology

Detalhes bibliográficos
Autor(a) principal: Loyola, Walter Aquiles Sepúlveda
Data de Publicação: 2024
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UEL
Texto Completo: https://repositorio.uel.br/handle/123456789/8795
Resumo: Tese (Doutorado em Ciências da Reabilitação) - Universidade Estadual de Londrina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Reabilitação
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spelling Theoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonologyGeriatriaIdososDoençasPneumologia - IdosoTratamentoGeriatricsElderly - DiseasesPulmonology - Rehabilitation - TreatmentTese (Doutorado em Ciências da Reabilitação) - Universidade Estadual de Londrina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências da ReabilitaçãoAbstract: Introduction: The following doctoral thesis aimed to answer the main gaps in the literature related to the relationship between COPD and sarcopenia, its clinical impact and associated biological factors Additionally, we have described and defined a new geriatric syndrome and proposed a new exercise program based on functional tasks in order to prevent and treat the functional impact caused by sarcopenia and other geriatric syndromes Methods: Seven studies were included in this thesis, developed in collaboration with different international research centers In the first study the clinical impact, prevalence and criteria to diagnose sarcopenia in individuals with COPD was investigated In the second study the main biological mechanisms associated with the prevalence of sarcopenia in individuals with COPD were investigated The third and fourth studies analysed the relationship between oxidative stress and some clinical variables related to the presence of sarcopenia in individuals with COPD In the fifth study the criteria and clinical impact of a new geriatric syndrome called osteosarcopenia were presented The sixth and seventh studies proposed a new exercise intervention method to treat older adults with geriatric syndromes Results: The first study reported that overall sarcopenia prevalence varied from 15% to 34%, being greater in people with more severe condition [37% (95%CI 248–54)] In addition, the presence of sarcopenia has a negative impact upon important clinical outcomes The second study found that oxidative stress, chronic inflammation, genetic and metabolic factors are the main biological mechanism related to the presence of sarcopenia in individuals with COPD The third and fourth studies reported that the total radical trapping antioxidant parameter (TRAP) and advanced oxidation protein products (AOPP) are important biomarkers related to clinical variables associated to sarcopenia in individuals with COPD and that antioxidant capacity was correlated with muscle mass and strength in this population (r from 5 to 64) The fifth study reported that osteosarcopenia (using the severe sarcopenia classification) conferred an increased rate of falls [odds ratios (ORs) from 283 to 363; P <5 for all] and fractures (ORs from 386 to 438; P < 5 for all) The sixth and seventh studies found that the exercise intervention method improves the clinical variables of sarcopenia in community older adults Conclusion: Sarcopenia is highly prevalent in individuals with COPD, generating a negative impact on various clinical variables Its origin is due to the presence of various factors such as oxidative stress and systemic inflammation related to COPD Sarcopenia may also be associated with low bone mineral mass, a syndrome called osteosarcopenia, which has a greater impact than sarcopenia alone Functional physical exercise could be a great intervention to reduce the risk of sarcopenia and other geriatric syndromes Since this exercise method has been studied in community older adults, future clinical randomized control trials are needed in individuals with COPD and other comorbiditiesProbst, Vanessa Suziane [Orientador]Camillo, Carlos Augusto MarçalMañas, Leocadio RodríguezTeixeira, Denilson de CastroOkamura, Larissa Araújo de CastroLoyola, Walter Aquiles Sepúlveda2024-05-01T11:40:24Z2024-05-01T11:40:24Z2022.0003.06.2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfhttps://repositorio.uel.br/handle/123456789/8795porDoutoradoCiências da ReabilitaçãoCentro de Ciências da SaúdePrograma de Pós-Graduação em Ciências da ReabilitaçãoLondrinareponame:Biblioteca Digital de Teses e Dissertações da UELinstname:Universidade Estadual de Londrina (UEL)instacron:UELinfo:eu-repo/semantics/openAccess2024-07-04T01:47:03Zoai:repositorio.uel.br:123456789/8795Biblioteca Digital de Teses e Dissertaçõeshttp://www.bibliotecadigital.uel.br/PUBhttp://www.bibliotecadigital.uel.br/OAI/oai2.phpbcuel@uel.br||opendoar:2024-07-04T01:47:03Biblioteca Digital de Teses e Dissertações da UEL - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv Theoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonology
title Theoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonology
spellingShingle Theoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonology
Loyola, Walter Aquiles Sepúlveda
Geriatria
Idosos
Doenças
Pneumologia - Idoso
Tratamento
Geriatrics
Elderly - Diseases
Pulmonology - Rehabilitation - Treatment
title_short Theoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonology
title_full Theoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonology
title_fullStr Theoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonology
title_full_unstemmed Theoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonology
title_sort Theoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonology
author Loyola, Walter Aquiles Sepúlveda
author_facet Loyola, Walter Aquiles Sepúlveda
author_role author
dc.contributor.none.fl_str_mv Probst, Vanessa Suziane [Orientador]
Camillo, Carlos Augusto Marçal
Mañas, Leocadio Rodríguez
Teixeira, Denilson de Castro
Okamura, Larissa Araújo de Castro
dc.contributor.author.fl_str_mv Loyola, Walter Aquiles Sepúlveda
dc.subject.por.fl_str_mv Geriatria
Idosos
Doenças
Pneumologia - Idoso
Tratamento
Geriatrics
Elderly - Diseases
Pulmonology - Rehabilitation - Treatment
topic Geriatria
Idosos
Doenças
Pneumologia - Idoso
Tratamento
Geriatrics
Elderly - Diseases
Pulmonology - Rehabilitation - Treatment
description Tese (Doutorado em Ciências da Reabilitação) - Universidade Estadual de Londrina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Reabilitação
publishDate 2024
dc.date.none.fl_str_mv 03.06.2022
2022.00
2024-05-01T11:40:24Z
2024-05-01T11:40:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.uel.br/handle/123456789/8795
url https://repositorio.uel.br/handle/123456789/8795
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Doutorado
Ciências da Reabilitação
Centro de Ciências da Saúde
Programa de Pós-Graduação em Ciências da Reabilitação
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Londrina
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UEL
instname:Universidade Estadual de Londrina (UEL)
instacron:UEL
instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Biblioteca Digital de Teses e Dissertações da UEL
collection Biblioteca Digital de Teses e Dissertações da UEL
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da UEL - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv bcuel@uel.br||
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