Effects of chronic exposure to hexavalent chromium in water on oxidative stress parameters in Wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Scientiarum Biological Sciences |
Texto Completo: | http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771 |
Resumo: | Hexavalent chromium [Cr (VI)] is a metal utilized in different industries and consequently disposed in the environment. It is a toxic substance and its reduction to trivalent Cr [Cr (III)] generates intermediates, which are responsible for the oxidation of molecules, and cause the oxidative stress. Therefore, the aim of this study was to evaluate if Cr (VI) could induce oxidative stress in Wistar rats. In this study, Wistar rats were chronically exposed to 25 and 50 ppm of potassium dichromate in drinking water for 30 days. The levels of Cr were evaluated in the blood and tissues (liver, kidneys, and lungs). Oxidative stress was determined in the liver, kidneys, and lungs and was evaluated by DFCH, TBA-RS and carbonyl test. Antioxidant enzymes were evaluated through catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Regarding the results, Cr concentration was significantly elevated in all tissues, however, it was lower in the lungs. In relation to the oxidative stress parameters, there was a significant increase of DCFH levels in the kidneys and carbonyls in liver and kidneys. Regarding the antioxidant enzymes, SOD was decreased in all organs and GPx was diminished in the kidneys. These data indicated that Cr (VI) could induce oxidative stress in the kidneys and liver due to an imbalance between oxidative and antioxidant parameters. The lungs were little affected, possibly by the lowest chromium accumulation. |
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Effects of chronic exposure to hexavalent chromium in water on oxidative stress parameters in Wistar ratsAntioxidant enzymesenvironmental contaminationhexavalent chromiumoxidative stress.BioquímicaHexavalent chromium [Cr (VI)] is a metal utilized in different industries and consequently disposed in the environment. It is a toxic substance and its reduction to trivalent Cr [Cr (III)] generates intermediates, which are responsible for the oxidation of molecules, and cause the oxidative stress. Therefore, the aim of this study was to evaluate if Cr (VI) could induce oxidative stress in Wistar rats. In this study, Wistar rats were chronically exposed to 25 and 50 ppm of potassium dichromate in drinking water for 30 days. The levels of Cr were evaluated in the blood and tissues (liver, kidneys, and lungs). Oxidative stress was determined in the liver, kidneys, and lungs and was evaluated by DFCH, TBA-RS and carbonyl test. Antioxidant enzymes were evaluated through catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Regarding the results, Cr concentration was significantly elevated in all tissues, however, it was lower in the lungs. In relation to the oxidative stress parameters, there was a significant increase of DCFH levels in the kidneys and carbonyls in liver and kidneys. Regarding the antioxidant enzymes, SOD was decreased in all organs and GPx was diminished in the kidneys. These data indicated that Cr (VI) could induce oxidative stress in the kidneys and liver due to an imbalance between oxidative and antioxidant parameters. The lungs were little affected, possibly by the lowest chromium accumulation.Universidade Estadual De Maringá2019-04-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/4377110.4025/actascibiolsci.v41i1.43771Acta Scientiarum. Biological Sciences; Vol 41 (2019): Publicação contínua; e43771Acta Scientiarum. Biological Sciences; v. 41 (2019): Publicação contínua; e437711807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/751375147482http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/751375147483http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/751375147495http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/751375147653http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/751375148026http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/751375148027Copyright (c) 2019 Acta Scientiarum. Biological Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMachado, Aline BelemCaprara, Juliana ForestiFranceschi, Itiane Diehl deLinden, RafaelBerlese, Daiane BolzanFeksa, Luciane Rosa2022-02-20T21:59:34Zoai:periodicos.uem.br/ojs:article/43771Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2022-02-20T21:59:34Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
Effects of chronic exposure to hexavalent chromium in water on oxidative stress parameters in Wistar rats |
title |
Effects of chronic exposure to hexavalent chromium in water on oxidative stress parameters in Wistar rats |
spellingShingle |
Effects of chronic exposure to hexavalent chromium in water on oxidative stress parameters in Wistar rats Machado, Aline Belem Antioxidant enzymes environmental contamination hexavalent chromium oxidative stress. Bioquímica |
title_short |
Effects of chronic exposure to hexavalent chromium in water on oxidative stress parameters in Wistar rats |
title_full |
Effects of chronic exposure to hexavalent chromium in water on oxidative stress parameters in Wistar rats |
title_fullStr |
Effects of chronic exposure to hexavalent chromium in water on oxidative stress parameters in Wistar rats |
title_full_unstemmed |
Effects of chronic exposure to hexavalent chromium in water on oxidative stress parameters in Wistar rats |
title_sort |
Effects of chronic exposure to hexavalent chromium in water on oxidative stress parameters in Wistar rats |
author |
Machado, Aline Belem |
author_facet |
Machado, Aline Belem Caprara, Juliana Foresti Franceschi, Itiane Diehl de Linden, Rafael Berlese, Daiane Bolzan Feksa, Luciane Rosa |
author_role |
author |
author2 |
Caprara, Juliana Foresti Franceschi, Itiane Diehl de Linden, Rafael Berlese, Daiane Bolzan Feksa, Luciane Rosa |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Machado, Aline Belem Caprara, Juliana Foresti Franceschi, Itiane Diehl de Linden, Rafael Berlese, Daiane Bolzan Feksa, Luciane Rosa |
dc.subject.por.fl_str_mv |
Antioxidant enzymes environmental contamination hexavalent chromium oxidative stress. Bioquímica |
topic |
Antioxidant enzymes environmental contamination hexavalent chromium oxidative stress. Bioquímica |
description |
Hexavalent chromium [Cr (VI)] is a metal utilized in different industries and consequently disposed in the environment. It is a toxic substance and its reduction to trivalent Cr [Cr (III)] generates intermediates, which are responsible for the oxidation of molecules, and cause the oxidative stress. Therefore, the aim of this study was to evaluate if Cr (VI) could induce oxidative stress in Wistar rats. In this study, Wistar rats were chronically exposed to 25 and 50 ppm of potassium dichromate in drinking water for 30 days. The levels of Cr were evaluated in the blood and tissues (liver, kidneys, and lungs). Oxidative stress was determined in the liver, kidneys, and lungs and was evaluated by DFCH, TBA-RS and carbonyl test. Antioxidant enzymes were evaluated through catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Regarding the results, Cr concentration was significantly elevated in all tissues, however, it was lower in the lungs. In relation to the oxidative stress parameters, there was a significant increase of DCFH levels in the kidneys and carbonyls in liver and kidneys. Regarding the antioxidant enzymes, SOD was decreased in all organs and GPx was diminished in the kidneys. These data indicated that Cr (VI) could induce oxidative stress in the kidneys and liver due to an imbalance between oxidative and antioxidant parameters. The lungs were little affected, possibly by the lowest chromium accumulation. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-04-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771 10.4025/actascibiolsci.v41i1.43771 |
url |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771 |
identifier_str_mv |
10.4025/actascibiolsci.v41i1.43771 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/pdf http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/751375147482 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/751375147483 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/751375147495 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/751375147653 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/751375148026 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/751375148027 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Acta Scientiarum. Biological Sciences https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Acta Scientiarum. Biological Sciences https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/vnd.openxmlformats-officedocument.wordprocessingml.document application/vnd.openxmlformats-officedocument.wordprocessingml.document application/vnd.openxmlformats-officedocument.wordprocessingml.document application/vnd.openxmlformats-officedocument.wordprocessingml.document application/vnd.openxmlformats-officedocument.wordprocessingml.document application/vnd.openxmlformats-officedocument.wordprocessingml.document |
dc.publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
dc.source.none.fl_str_mv |
Acta Scientiarum. Biological Sciences; Vol 41 (2019): Publicação contínua; e43771 Acta Scientiarum. Biological Sciences; v. 41 (2019): Publicação contínua; e43771 1807-863X 1679-9283 reponame:Acta Scientiarum Biological Sciences instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
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Universidade Estadual de Maringá (UEM) |
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UEM |
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UEM |
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Acta Scientiarum Biological Sciences |
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Acta Scientiarum Biological Sciences |
repository.name.fl_str_mv |
Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
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