Maternal and fetal toxicity of Wistar rats exposed to herbicide metolachlor
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Scientiarum Biological Sciences |
Texto Completo: | http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/29079 |
Resumo: | Metolachlor is a selective pre-emergent herbicide widely used in agriculture to control weeds. The aim of this study was to evaluate the possible effects of metolachlor on reproductive performance of adult rats, as well as its teratogenic potential when administered during the period of organogenesis. Pregnant adult female rats were allocated into 4 experimental groups (n = 10 group-1), that received 0 (control); 150 (TA); 300 (TB); or 1000 mg kg-1 bw day-1 (TC) of metolachlor, by gavage, from the 6th to 15th gestational day (GD). There is reduction in the weight gain of the animals from TB and TC groups compared to the control group. Liver and placenta weights were reduced in TB and TC groups, respectively, while the percentage of post-implantation loss was increased in the TC group. There were no external malformations in either rat of the control or treated groups. However, an increased incidence of skeletal anomalies and visceral anomalies (especially in the urogenital system) was observed in TC group. These results demonstrate that exposure of pregnant rats to metolachlor can lead to signs of general toxicity, late embryonic losses and congenital anomalies. |
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Acta Scientiarum Biological Sciences |
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Maternal and fetal toxicity of Wistar rats exposed to herbicide metolachlorpesticidereproductionteratogenicityfetusMetolachlor is a selective pre-emergent herbicide widely used in agriculture to control weeds. The aim of this study was to evaluate the possible effects of metolachlor on reproductive performance of adult rats, as well as its teratogenic potential when administered during the period of organogenesis. Pregnant adult female rats were allocated into 4 experimental groups (n = 10 group-1), that received 0 (control); 150 (TA); 300 (TB); or 1000 mg kg-1 bw day-1 (TC) of metolachlor, by gavage, from the 6th to 15th gestational day (GD). There is reduction in the weight gain of the animals from TB and TC groups compared to the control group. Liver and placenta weights were reduced in TB and TC groups, respectively, while the percentage of post-implantation loss was increased in the TC group. There were no external malformations in either rat of the control or treated groups. However, an increased incidence of skeletal anomalies and visceral anomalies (especially in the urogenital system) was observed in TC group. These results demonstrate that exposure of pregnant rats to metolachlor can lead to signs of general toxicity, late embryonic losses and congenital anomalies. Universidade Estadual De Maringá2016-07-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/2907910.4025/actascibiolsci.v38i1.29079Acta Scientiarum. Biological Sciences; Vol 38 No 1 (2016); 91-98Acta Scientiarum. Biological Sciences; v. 38 n. 1 (2016); 91-981807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/29079/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/29079/751375144116http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/29079/751375144117Tavares Vieira, Kátia Cristina de MeloCouto, Jennifer CardosoZanetti, EdsonSanches Junior, José MarcosFavareto, Ana Paula Alvesinfo:eu-repo/semantics/openAccess2022-02-17T22:00:56Zoai:periodicos.uem.br/ojs:article/29079Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2022-02-17T22:00:56Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
Maternal and fetal toxicity of Wistar rats exposed to herbicide metolachlor |
title |
Maternal and fetal toxicity of Wistar rats exposed to herbicide metolachlor |
spellingShingle |
Maternal and fetal toxicity of Wistar rats exposed to herbicide metolachlor Tavares Vieira, Kátia Cristina de Melo pesticide reproduction teratogenicity fetus |
title_short |
Maternal and fetal toxicity of Wistar rats exposed to herbicide metolachlor |
title_full |
Maternal and fetal toxicity of Wistar rats exposed to herbicide metolachlor |
title_fullStr |
Maternal and fetal toxicity of Wistar rats exposed to herbicide metolachlor |
title_full_unstemmed |
Maternal and fetal toxicity of Wistar rats exposed to herbicide metolachlor |
title_sort |
Maternal and fetal toxicity of Wistar rats exposed to herbicide metolachlor |
author |
Tavares Vieira, Kátia Cristina de Melo |
author_facet |
Tavares Vieira, Kátia Cristina de Melo Couto, Jennifer Cardoso Zanetti, Edson Sanches Junior, José Marcos Favareto, Ana Paula Alves |
author_role |
author |
author2 |
Couto, Jennifer Cardoso Zanetti, Edson Sanches Junior, José Marcos Favareto, Ana Paula Alves |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Tavares Vieira, Kátia Cristina de Melo Couto, Jennifer Cardoso Zanetti, Edson Sanches Junior, José Marcos Favareto, Ana Paula Alves |
dc.subject.por.fl_str_mv |
pesticide reproduction teratogenicity fetus |
topic |
pesticide reproduction teratogenicity fetus |
description |
Metolachlor is a selective pre-emergent herbicide widely used in agriculture to control weeds. The aim of this study was to evaluate the possible effects of metolachlor on reproductive performance of adult rats, as well as its teratogenic potential when administered during the period of organogenesis. Pregnant adult female rats were allocated into 4 experimental groups (n = 10 group-1), that received 0 (control); 150 (TA); 300 (TB); or 1000 mg kg-1 bw day-1 (TC) of metolachlor, by gavage, from the 6th to 15th gestational day (GD). There is reduction in the weight gain of the animals from TB and TC groups compared to the control group. Liver and placenta weights were reduced in TB and TC groups, respectively, while the percentage of post-implantation loss was increased in the TC group. There were no external malformations in either rat of the control or treated groups. However, an increased incidence of skeletal anomalies and visceral anomalies (especially in the urogenital system) was observed in TC group. These results demonstrate that exposure of pregnant rats to metolachlor can lead to signs of general toxicity, late embryonic losses and congenital anomalies. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-07-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/29079 10.4025/actascibiolsci.v38i1.29079 |
url |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/29079 |
identifier_str_mv |
10.4025/actascibiolsci.v38i1.29079 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/29079/pdf http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/29079/751375144116 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/29079/751375144117 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
dc.source.none.fl_str_mv |
Acta Scientiarum. Biological Sciences; Vol 38 No 1 (2016); 91-98 Acta Scientiarum. Biological Sciences; v. 38 n. 1 (2016); 91-98 1807-863X 1679-9283 reponame:Acta Scientiarum Biological Sciences instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Acta Scientiarum Biological Sciences |
collection |
Acta Scientiarum Biological Sciences |
repository.name.fl_str_mv |
Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
||actabiol@uem.br |
_version_ |
1799317396404568064 |