Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/01480545.2022.2070197 http://hdl.handle.net/11449/241216 |
Resumo: | Morinda citrifolia L., also known as Noni, is widely used plant in folk medicine for various therapeutic purposes. However, reports on its effects during pregnancy are limited. Therefore, the objective of this study was to evaluate the effects of the M. citrifolia fruit extract on maternal performance and fetal development during pregnancy in rats. Pregnant Wistar rats (n = 12/group) were treated from gestational days (GD) 0–21 with water (control group) or the aqueous extract of M. citrifolia fruit at doses of 200, 400, or 750 mg/kg, orally. During pregnancy, clinical signs of toxicity, maternal weight, feed intake, and water consumption were noted. On GD 21, the rats were anesthetized and blood was collected to evaluate various biochemical parameters. During laparotomy, reproductive performance parameters were recorded, and fetuses were weighed and the anomalies analyzed. Reduced placental efficiency and fetal growth restriction were observed in the group treated with 400 mg/kg of M. citrifolia extract. The highest dose (750 mg/kg) augmented aspartate aminotransferase concentration and preimplantation losses, while reducing the number of live fetuses. Furthermore, both doses (400 and 750 mg/kg) of the plant extract caused fetal anomalies. In conclusion, consumption of high doses of the M. citrifolia aqueous extrac during pregnancy leads to maternal hepatotoxicity, anti-implantation effects, intrauterine growth restriction and fetal abnormalities, indicating that the plant fruit extract can be harmful to both the mother and the fetus. |
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Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in ratsanti-implantationmaternal toxicityNoniratsteratogenicityMorinda citrifolia L., also known as Noni, is widely used plant in folk medicine for various therapeutic purposes. However, reports on its effects during pregnancy are limited. Therefore, the objective of this study was to evaluate the effects of the M. citrifolia fruit extract on maternal performance and fetal development during pregnancy in rats. Pregnant Wistar rats (n = 12/group) were treated from gestational days (GD) 0–21 with water (control group) or the aqueous extract of M. citrifolia fruit at doses of 200, 400, or 750 mg/kg, orally. During pregnancy, clinical signs of toxicity, maternal weight, feed intake, and water consumption were noted. On GD 21, the rats were anesthetized and blood was collected to evaluate various biochemical parameters. During laparotomy, reproductive performance parameters were recorded, and fetuses were weighed and the anomalies analyzed. Reduced placental efficiency and fetal growth restriction were observed in the group treated with 400 mg/kg of M. citrifolia extract. The highest dose (750 mg/kg) augmented aspartate aminotransferase concentration and preimplantation losses, while reducing the number of live fetuses. Furthermore, both doses (400 and 750 mg/kg) of the plant extract caused fetal anomalies. In conclusion, consumption of high doses of the M. citrifolia aqueous extrac during pregnancy leads to maternal hepatotoxicity, anti-implantation effects, intrauterine growth restriction and fetal abnormalities, indicating that the plant fruit extract can be harmful to both the mother and the fetus.Laboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT)Laboratory of Experimental Research on Gynecology and Obstetrics Graduate Program on Gynecology Obstetrics and Mastology Sao Paulo State University (UNESP)Federal University of Mato Grosso Institute of Health Sciences and HealthLaboratory of Experimental Research on Gynecology and Obstetrics Graduate Program on Gynecology Obstetrics and Mastology Sao Paulo State University (UNESP)Federal University of Mato Grosso (UFMT)Universidade Estadual Paulista (UNESP)Institute of Health Sciences and HealthLeal-Silva, ThaísSouza, Maysa Rocha [UNESP]Cruz, Larissa Lopes [UNESP]Moraes-Souza, Rafaianne Queiroz [UNESP]Paula, Verônyca Gonçalves [UNESP]Soares, Thaigra SousaDela Justina, VanessaGiachini, Fernanda ReginaDamasceno, Débora Cristina [UNESP]Américo, Madileine FrancelyVolpato, Gustavo Tadeu2023-03-01T20:52:08Z2023-03-01T20:52:08Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/01480545.2022.2070197Drug and Chemical Toxicology.1525-60140148-0545http://hdl.handle.net/11449/24121610.1080/01480545.2022.20701972-s2.0-85132674215Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDrug and Chemical Toxicologyinfo:eu-repo/semantics/openAccess2024-08-16T14:07:21Zoai:repositorio.unesp.br:11449/241216Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:07:21Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats |
title |
Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats |
spellingShingle |
Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats Leal-Silva, Thaís anti-implantation maternal toxicity Noni rats teratogenicity |
title_short |
Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats |
title_full |
Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats |
title_fullStr |
Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats |
title_full_unstemmed |
Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats |
title_sort |
Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats |
author |
Leal-Silva, Thaís |
author_facet |
Leal-Silva, Thaís Souza, Maysa Rocha [UNESP] Cruz, Larissa Lopes [UNESP] Moraes-Souza, Rafaianne Queiroz [UNESP] Paula, Verônyca Gonçalves [UNESP] Soares, Thaigra Sousa Dela Justina, Vanessa Giachini, Fernanda Regina Damasceno, Débora Cristina [UNESP] Américo, Madileine Francely Volpato, Gustavo Tadeu |
author_role |
author |
author2 |
Souza, Maysa Rocha [UNESP] Cruz, Larissa Lopes [UNESP] Moraes-Souza, Rafaianne Queiroz [UNESP] Paula, Verônyca Gonçalves [UNESP] Soares, Thaigra Sousa Dela Justina, Vanessa Giachini, Fernanda Regina Damasceno, Débora Cristina [UNESP] Américo, Madileine Francely Volpato, Gustavo Tadeu |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Federal University of Mato Grosso (UFMT) Universidade Estadual Paulista (UNESP) Institute of Health Sciences and Health |
dc.contributor.author.fl_str_mv |
Leal-Silva, Thaís Souza, Maysa Rocha [UNESP] Cruz, Larissa Lopes [UNESP] Moraes-Souza, Rafaianne Queiroz [UNESP] Paula, Verônyca Gonçalves [UNESP] Soares, Thaigra Sousa Dela Justina, Vanessa Giachini, Fernanda Regina Damasceno, Débora Cristina [UNESP] Américo, Madileine Francely Volpato, Gustavo Tadeu |
dc.subject.por.fl_str_mv |
anti-implantation maternal toxicity Noni rats teratogenicity |
topic |
anti-implantation maternal toxicity Noni rats teratogenicity |
description |
Morinda citrifolia L., also known as Noni, is widely used plant in folk medicine for various therapeutic purposes. However, reports on its effects during pregnancy are limited. Therefore, the objective of this study was to evaluate the effects of the M. citrifolia fruit extract on maternal performance and fetal development during pregnancy in rats. Pregnant Wistar rats (n = 12/group) were treated from gestational days (GD) 0–21 with water (control group) or the aqueous extract of M. citrifolia fruit at doses of 200, 400, or 750 mg/kg, orally. During pregnancy, clinical signs of toxicity, maternal weight, feed intake, and water consumption were noted. On GD 21, the rats were anesthetized and blood was collected to evaluate various biochemical parameters. During laparotomy, reproductive performance parameters were recorded, and fetuses were weighed and the anomalies analyzed. Reduced placental efficiency and fetal growth restriction were observed in the group treated with 400 mg/kg of M. citrifolia extract. The highest dose (750 mg/kg) augmented aspartate aminotransferase concentration and preimplantation losses, while reducing the number of live fetuses. Furthermore, both doses (400 and 750 mg/kg) of the plant extract caused fetal anomalies. In conclusion, consumption of high doses of the M. citrifolia aqueous extrac during pregnancy leads to maternal hepatotoxicity, anti-implantation effects, intrauterine growth restriction and fetal abnormalities, indicating that the plant fruit extract can be harmful to both the mother and the fetus. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-03-01T20:52:08Z 2023-03-01T20:52:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/01480545.2022.2070197 Drug and Chemical Toxicology. 1525-6014 0148-0545 http://hdl.handle.net/11449/241216 10.1080/01480545.2022.2070197 2-s2.0-85132674215 |
url |
http://dx.doi.org/10.1080/01480545.2022.2070197 http://hdl.handle.net/11449/241216 |
identifier_str_mv |
Drug and Chemical Toxicology. 1525-6014 0148-0545 10.1080/01480545.2022.2070197 2-s2.0-85132674215 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Drug and Chemical Toxicology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128159130845184 |