The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution

Detalhes bibliográficos
Autor(a) principal: Ansolin, Tathiane Lilian
Data de Publicação: 2014
Outros Autores: Bariccatti, Reinaldo Aparecido, Rosa, Mauricio Ferreira da, Lindino, Cleber Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta scientiarum. Technology (Online)
Texto Completo: http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/17554
Resumo: The degradation of propranolol hydrochloride (1-isopropylamino-3-(naphthoxy)-2-propranolol) in an aqueous solution was analyzed when irradiated by light UV, with and without β-cyclodextrin. There was an increase in the compound´s photostability in nanocavity when compared with the drug without the cyclodextrins’ cavity. First order kinetic model was employed for the degradation of propranolol in aqueous media and in cyclodextrins’ cavity. The kinetic parameter was obtained by the drug´s absorption and electronic fluorescence. As a rule, encapsulation of propranolol in β-cyclodextrin decreases photodegradation speed by 53%. 
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spelling The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solutionnanocavitydrugphotochemicalCinética de degradação de fármaco em nanocavidadesThe degradation of propranolol hydrochloride (1-isopropylamino-3-(naphthoxy)-2-propranolol) in an aqueous solution was analyzed when irradiated by light UV, with and without β-cyclodextrin. There was an increase in the compound´s photostability in nanocavity when compared with the drug without the cyclodextrins’ cavity. First order kinetic model was employed for the degradation of propranolol in aqueous media and in cyclodextrins’ cavity. The kinetic parameter was obtained by the drug´s absorption and electronic fluorescence. As a rule, encapsulation of propranolol in β-cyclodextrin decreases photodegradation speed by 53%. Universidade Estadual De Maringá2014-04-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionestudos cinéticos e espectroscópicosapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/1755410.4025/actascitechnol.v36i2.17554Acta Scientiarum. Technology; Vol 36 No 2 (2014); 337-340Acta Scientiarum. Technology; v. 36 n. 2 (2014); 337-3401806-25631807-8664reponame:Acta scientiarum. Technology (Online)instname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/17554/12667Ansolin, Tathiane LilianBariccatti, Reinaldo AparecidoRosa, Mauricio Ferreira daLindino, Cleber Antonioinfo:eu-repo/semantics/openAccess2014-04-04T15:34:15Zoai:periodicos.uem.br/ojs:article/17554Revistahttps://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/indexPUBhttps://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/oai||actatech@uem.br1807-86641806-2563opendoar:2014-04-04T15:34:15Acta scientiarum. Technology (Online) - Universidade Estadual de Maringá (UEM)false
dc.title.none.fl_str_mv The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution
title The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution
spellingShingle The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution
Ansolin, Tathiane Lilian
nanocavity
drug
photochemical
Cinética de degradação de fármaco em nanocavidades
title_short The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution
title_full The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution
title_fullStr The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution
title_full_unstemmed The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution
title_sort The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution
author Ansolin, Tathiane Lilian
author_facet Ansolin, Tathiane Lilian
Bariccatti, Reinaldo Aparecido
Rosa, Mauricio Ferreira da
Lindino, Cleber Antonio
author_role author
author2 Bariccatti, Reinaldo Aparecido
Rosa, Mauricio Ferreira da
Lindino, Cleber Antonio
author2_role author
author
author
dc.contributor.author.fl_str_mv Ansolin, Tathiane Lilian
Bariccatti, Reinaldo Aparecido
Rosa, Mauricio Ferreira da
Lindino, Cleber Antonio
dc.subject.por.fl_str_mv nanocavity
drug
photochemical
Cinética de degradação de fármaco em nanocavidades
topic nanocavity
drug
photochemical
Cinética de degradação de fármaco em nanocavidades
description The degradation of propranolol hydrochloride (1-isopropylamino-3-(naphthoxy)-2-propranolol) in an aqueous solution was analyzed when irradiated by light UV, with and without β-cyclodextrin. There was an increase in the compound´s photostability in nanocavity when compared with the drug without the cyclodextrins’ cavity. First order kinetic model was employed for the degradation of propranolol in aqueous media and in cyclodextrins’ cavity. The kinetic parameter was obtained by the drug´s absorption and electronic fluorescence. As a rule, encapsulation of propranolol in β-cyclodextrin decreases photodegradation speed by 53%. 
publishDate 2014
dc.date.none.fl_str_mv 2014-04-04
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
estudos cinéticos e espectroscópicos
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/17554
10.4025/actascitechnol.v36i2.17554
url http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/17554
identifier_str_mv 10.4025/actascitechnol.v36i2.17554
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/17554/12667
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual De Maringá
publisher.none.fl_str_mv Universidade Estadual De Maringá
dc.source.none.fl_str_mv Acta Scientiarum. Technology; Vol 36 No 2 (2014); 337-340
Acta Scientiarum. Technology; v. 36 n. 2 (2014); 337-340
1806-2563
1807-8664
reponame:Acta scientiarum. Technology (Online)
instname:Universidade Estadual de Maringá (UEM)
instacron:UEM
instname_str Universidade Estadual de Maringá (UEM)
instacron_str UEM
institution UEM
reponame_str Acta scientiarum. Technology (Online)
collection Acta scientiarum. Technology (Online)
repository.name.fl_str_mv Acta scientiarum. Technology (Online) - Universidade Estadual de Maringá (UEM)
repository.mail.fl_str_mv ||actatech@uem.br
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