Association between the IGF-2/APAI polymorphism with the strength and muscle mass in elderly women

Detalhes bibliográficos
Autor(a) principal: Oliveira, Ricardo Jacó de
Data de Publicação: 2013
Outros Autores: Lima, Ricardo Moreno, Silva, Michel Santos, Silva, Maria Alcione Freitas e, Bezerra, Lídia Maria Aguiar, Guimarães, Andréa Carmem, Pereira, Rinaldo Wellerson
Tipo de documento: Artigo
Idioma: por
Título da fonte: Journal of Physical Education (Maringá)
Texto Completo: https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/15238
Resumo: Sarcopenia reduces functional capacity in elderly people. The candidate gene Insulin Growth Factor (IGF-2) has been suggested to influence on sarcopenia. This study aimed to investigate the association between the IGF-2 / ApaI polymorphism and the phenotypes muscle mass and strength. The study involved 252 subjects (66.94 ± 5.59 years), who underwent muscle strength measurements using an isokinetic dynamometer, and fat-free mass (FFM) assessment using DEXA. Volunteers also answered the IPAQ questionnaire to determine physical activity levels. Statistical procedures included ANOVA and ANCOVA to compare variables (p< 0.05). No significant difference was detected between age, weight, height, BMI and body fat percentage in the three genotype groups. The analysis of covariance evidenced no significant difference between groups regarding the evaluated muscle-related phenotypes. Therefore, there was no significant association between IGF-2 / ApaI polymorphism with isokinetic muscle strength and FFM in this population.
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spelling Association between the IGF-2/APAI polymorphism with the strength and muscle mass in elderly womenAssociação do polimorfismo ApaI do gene IGF-2 com a força e a massa muscular em idosas brasileiras doi:10.4025/reveducfis.v23i4.15238IGF-2StrengthElderly.IGF-2StrengthElderly.IGF-2forçaidosasGenéticaSarcopenia reduces functional capacity in elderly people. The candidate gene Insulin Growth Factor (IGF-2) has been suggested to influence on sarcopenia. This study aimed to investigate the association between the IGF-2 / ApaI polymorphism and the phenotypes muscle mass and strength. The study involved 252 subjects (66.94 ± 5.59 years), who underwent muscle strength measurements using an isokinetic dynamometer, and fat-free mass (FFM) assessment using DEXA. Volunteers also answered the IPAQ questionnaire to determine physical activity levels. Statistical procedures included ANOVA and ANCOVA to compare variables (p< 0.05). No significant difference was detected between age, weight, height, BMI and body fat percentage in the three genotype groups. The analysis of covariance evidenced no significant difference between groups regarding the evaluated muscle-related phenotypes. Therefore, there was no significant association between IGF-2 / ApaI polymorphism with isokinetic muscle strength and FFM in this population.A sarcopenia diminui a capacidade funcional do idoso. O gene candidato IGF-2 tem influência na sarcopenia. Investigou-se a associação entre o polimorfismo ApaI do gene IGF-2 e os fenótipos força e massa muscular considerando-se os padrões de atividade física. Participaram do estudo 252 brasileiras (66,94 ± 5,59 anos), as quais tiveram a força muscular mensurada em aparelho isocinético, a MLG não óssea analisada pelo DXA e responderam um questionário determinando o nível de atividade física. O DNA genômico extraído foi genotipado para o polimorfismo ApaI do gene IGF-2. Não houve diferença significativa entre as variáveis idade, massa corporal, estatura, IMC e o percentual de gordura (p>0,05). A análise de covariância demonstrou que não houve diferenças significativas entre os grupos genotípicos (GG, GA, AA) com os fenótipos analisados. Portanto, não houve associações significativas entre o polimorfismo ApaI do IGF-2 com a força muscular isocinética e a massa livre de gordura.Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil2013-01-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionDescriptive researchEstudo Transversalapplication/pdfapplication/pdfhttps://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/15238Journal of Physical Education; Vol 23 No 4 (2012); 617-628Journal of Physical Education; Vol. 23 Núm. 4 (2012); 617-628Journal of Physical Education; v. 23 n. 4 (2012); 617-6282448-2455reponame:Journal of Physical Education (Maringá)instname:Universidade Estadual de Maringá (UEM)instacron:UEMporhttps://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/15238/11089https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/15238/751375141501Oliveira, Ricardo Jacó deLima, Ricardo MorenoSilva, Michel SantosSilva, Maria Alcione Freitas eBezerra, Lídia Maria AguiarGuimarães, Andréa CarmemPereira, Rinaldo Wellersoninfo:eu-repo/semantics/openAccess2023-01-10T15:38:14Zoai:periodicos.uem.br/ojs:article/15238Revistahttp://periodicos.uem.br/ojs/index.php/RevEducFis/indexPUBhttps://old.scielo.br/oai/scielo-oai.php||revdef@uem.br2448-24552448-2455opendoar:2023-01-10T15:38:14Journal of Physical Education (Maringá) - Universidade Estadual de Maringá (UEM)false
dc.title.none.fl_str_mv Association between the IGF-2/APAI polymorphism with the strength and muscle mass in elderly women
Associação do polimorfismo ApaI do gene IGF-2 com a força e a massa muscular em idosas brasileiras doi:10.4025/reveducfis.v23i4.15238
title Association between the IGF-2/APAI polymorphism with the strength and muscle mass in elderly women
spellingShingle Association between the IGF-2/APAI polymorphism with the strength and muscle mass in elderly women
Oliveira, Ricardo Jacó de
IGF-2
Strength
Elderly.
IGF-2
Strength
Elderly.
IGF-2
força
idosas
Genética
title_short Association between the IGF-2/APAI polymorphism with the strength and muscle mass in elderly women
title_full Association between the IGF-2/APAI polymorphism with the strength and muscle mass in elderly women
title_fullStr Association between the IGF-2/APAI polymorphism with the strength and muscle mass in elderly women
title_full_unstemmed Association between the IGF-2/APAI polymorphism with the strength and muscle mass in elderly women
title_sort Association between the IGF-2/APAI polymorphism with the strength and muscle mass in elderly women
author Oliveira, Ricardo Jacó de
author_facet Oliveira, Ricardo Jacó de
Lima, Ricardo Moreno
Silva, Michel Santos
Silva, Maria Alcione Freitas e
Bezerra, Lídia Maria Aguiar
Guimarães, Andréa Carmem
Pereira, Rinaldo Wellerson
author_role author
author2 Lima, Ricardo Moreno
Silva, Michel Santos
Silva, Maria Alcione Freitas e
Bezerra, Lídia Maria Aguiar
Guimarães, Andréa Carmem
Pereira, Rinaldo Wellerson
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Ricardo Jacó de
Lima, Ricardo Moreno
Silva, Michel Santos
Silva, Maria Alcione Freitas e
Bezerra, Lídia Maria Aguiar
Guimarães, Andréa Carmem
Pereira, Rinaldo Wellerson
dc.subject.por.fl_str_mv IGF-2
Strength
Elderly.
IGF-2
Strength
Elderly.
IGF-2
força
idosas
Genética
topic IGF-2
Strength
Elderly.
IGF-2
Strength
Elderly.
IGF-2
força
idosas
Genética
description Sarcopenia reduces functional capacity in elderly people. The candidate gene Insulin Growth Factor (IGF-2) has been suggested to influence on sarcopenia. This study aimed to investigate the association between the IGF-2 / ApaI polymorphism and the phenotypes muscle mass and strength. The study involved 252 subjects (66.94 ± 5.59 years), who underwent muscle strength measurements using an isokinetic dynamometer, and fat-free mass (FFM) assessment using DEXA. Volunteers also answered the IPAQ questionnaire to determine physical activity levels. Statistical procedures included ANOVA and ANCOVA to compare variables (p< 0.05). No significant difference was detected between age, weight, height, BMI and body fat percentage in the three genotype groups. The analysis of covariance evidenced no significant difference between groups regarding the evaluated muscle-related phenotypes. Therefore, there was no significant association between IGF-2 / ApaI polymorphism with isokinetic muscle strength and FFM in this population.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Descriptive research
Estudo Transversal
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/15238
url https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/15238
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/15238/11089
https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/15238/751375141501
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil
publisher.none.fl_str_mv Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil
dc.source.none.fl_str_mv Journal of Physical Education; Vol 23 No 4 (2012); 617-628
Journal of Physical Education; Vol. 23 Núm. 4 (2012); 617-628
Journal of Physical Education; v. 23 n. 4 (2012); 617-628
2448-2455
reponame:Journal of Physical Education (Maringá)
instname:Universidade Estadual de Maringá (UEM)
instacron:UEM
instname_str Universidade Estadual de Maringá (UEM)
instacron_str UEM
institution UEM
reponame_str Journal of Physical Education (Maringá)
collection Journal of Physical Education (Maringá)
repository.name.fl_str_mv Journal of Physical Education (Maringá) - Universidade Estadual de Maringá (UEM)
repository.mail.fl_str_mv ||revdef@uem.br
_version_ 1754732543425380352

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