A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online) |
Texto Completo: | https://revista.uepb.edu.br/PBOCI/article/view/3327 |
Resumo: | Objective: To assess the agreement among three different online drug-drug interaction (DDI) checkers for the detection of psychotropic drug interactions among dental patients in the state of Minas Gerais, Brazil. Material and Methods: Between January and December 2017, a cross-sectional study was conducted in Minas Gerais with data on pharmaceutical claims of psychotropic drugs prescribed by dental practitioners. Data from the Pharmaceutical Management System provided the drug dispensing history of the patients, allowing the identification of those on concomitant medication use. The occurrence of DDI was determined by entering the name of the drugs taken by each patient into Merative Micromedex®, Medscape®, and DrugBank. The degree of agreement among the three DDI online checkers was analyzed using the Fleiss' kappa test. Results: Overall, 797 dental patients were found to be taking some psychotropic medication with other drugs simultaneously. The number of patients with DDI varied according to Micromedex® (n= 366), Medscape® (n= 473), and DrugBank (n= 736). The agreement between the DDI checkers was poor (Fleiss' kappa: 0.165; p<0.001). Conclusion: The online DDI checkers assessed in this study showed variations in their ability to detect interactions and poor agreement among them. |
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A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short CommunicationDentistryPsychotropic DrugsDrug InteractionsDecision Support Systems, ClinicalObjective: To assess the agreement among three different online drug-drug interaction (DDI) checkers for the detection of psychotropic drug interactions among dental patients in the state of Minas Gerais, Brazil. Material and Methods: Between January and December 2017, a cross-sectional study was conducted in Minas Gerais with data on pharmaceutical claims of psychotropic drugs prescribed by dental practitioners. Data from the Pharmaceutical Management System provided the drug dispensing history of the patients, allowing the identification of those on concomitant medication use. The occurrence of DDI was determined by entering the name of the drugs taken by each patient into Merative Micromedex®, Medscape®, and DrugBank. The degree of agreement among the three DDI online checkers was analyzed using the Fleiss' kappa test. Results: Overall, 797 dental patients were found to be taking some psychotropic medication with other drugs simultaneously. The number of patients with DDI varied according to Micromedex® (n= 366), Medscape® (n= 473), and DrugBank (n= 736). The agreement between the DDI checkers was poor (Fleiss' kappa: 0.165; p<0.001). Conclusion: The online DDI checkers assessed in this study showed variations in their ability to detect interactions and poor agreement among them.EDUEPB - EDITORA DA UNIVERSIDADE ESTADUAL DA PARAÍBA2024-04-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revista.uepb.edu.br/PBOCI/article/view/3327Pesquisa Brasileira em Odontopediatria e Clínica Integrada; Vol. 24 (2024); e230193Pesquisa Brasileira em Odontopediatria e Clínica Integrada; v. 24 (2024); e2301931983-46321519-0501reponame:Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online)instname:Universidade Estadual da Paraíba (UEPB)instacron:UEPBenghttps://revista.uepb.edu.br/PBOCI/article/view/3327/2320Copyright (c) 2023 Pesquisa Brasileira em Odontopediatria e Clínica Integradahttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessAguilar, Diego Rodrigues deCruz, Alex Junio SilvaMartins, Maria Auxiliadora ParreirasAbreu, Mauro Henrique Nogueira Guimarães2024-04-09T14:03:38Zoai:ojs.pkp.sfu.ca:article/3327Revistahttps://revista.uepb.edu.br/PBOCI/PUBhttps://revista.uepb.edu.br/PBOCI/oaipboci.editoria@gmail.com || alessandrouepb@gmail.com1983-46321519-0501opendoar:2024-04-09T14:03:38Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online) - Universidade Estadual da Paraíba (UEPB)false |
dc.title.none.fl_str_mv |
A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication |
title |
A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication |
spellingShingle |
A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication Aguilar, Diego Rodrigues de Dentistry Psychotropic Drugs Drug Interactions Decision Support Systems, Clinical |
title_short |
A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication |
title_full |
A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication |
title_fullStr |
A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication |
title_full_unstemmed |
A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication |
title_sort |
A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication |
author |
Aguilar, Diego Rodrigues de |
author_facet |
Aguilar, Diego Rodrigues de Cruz, Alex Junio Silva Martins, Maria Auxiliadora Parreiras Abreu, Mauro Henrique Nogueira Guimarães |
author_role |
author |
author2 |
Cruz, Alex Junio Silva Martins, Maria Auxiliadora Parreiras Abreu, Mauro Henrique Nogueira Guimarães |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Aguilar, Diego Rodrigues de Cruz, Alex Junio Silva Martins, Maria Auxiliadora Parreiras Abreu, Mauro Henrique Nogueira Guimarães |
dc.subject.por.fl_str_mv |
Dentistry Psychotropic Drugs Drug Interactions Decision Support Systems, Clinical |
topic |
Dentistry Psychotropic Drugs Drug Interactions Decision Support Systems, Clinical |
description |
Objective: To assess the agreement among three different online drug-drug interaction (DDI) checkers for the detection of psychotropic drug interactions among dental patients in the state of Minas Gerais, Brazil. Material and Methods: Between January and December 2017, a cross-sectional study was conducted in Minas Gerais with data on pharmaceutical claims of psychotropic drugs prescribed by dental practitioners. Data from the Pharmaceutical Management System provided the drug dispensing history of the patients, allowing the identification of those on concomitant medication use. The occurrence of DDI was determined by entering the name of the drugs taken by each patient into Merative Micromedex®, Medscape®, and DrugBank. The degree of agreement among the three DDI online checkers was analyzed using the Fleiss' kappa test. Results: Overall, 797 dental patients were found to be taking some psychotropic medication with other drugs simultaneously. The number of patients with DDI varied according to Micromedex® (n= 366), Medscape® (n= 473), and DrugBank (n= 736). The agreement between the DDI checkers was poor (Fleiss' kappa: 0.165; p<0.001). Conclusion: The online DDI checkers assessed in this study showed variations in their ability to detect interactions and poor agreement among them. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-04-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revista.uepb.edu.br/PBOCI/article/view/3327 |
url |
https://revista.uepb.edu.br/PBOCI/article/view/3327 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.uepb.edu.br/PBOCI/article/view/3327/2320 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Pesquisa Brasileira em Odontopediatria e Clínica Integrada https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Pesquisa Brasileira em Odontopediatria e Clínica Integrada https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
EDUEPB - EDITORA DA UNIVERSIDADE ESTADUAL DA PARAÍBA |
publisher.none.fl_str_mv |
EDUEPB - EDITORA DA UNIVERSIDADE ESTADUAL DA PARAÍBA |
dc.source.none.fl_str_mv |
Pesquisa Brasileira em Odontopediatria e Clínica Integrada; Vol. 24 (2024); e230193 Pesquisa Brasileira em Odontopediatria e Clínica Integrada; v. 24 (2024); e230193 1983-4632 1519-0501 reponame:Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online) instname:Universidade Estadual da Paraíba (UEPB) instacron:UEPB |
instname_str |
Universidade Estadual da Paraíba (UEPB) |
instacron_str |
UEPB |
institution |
UEPB |
reponame_str |
Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online) |
collection |
Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online) |
repository.name.fl_str_mv |
Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online) - Universidade Estadual da Paraíba (UEPB) |
repository.mail.fl_str_mv |
pboci.editoria@gmail.com || alessandrouepb@gmail.com |
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1803387864368545792 |