EFEITO DE DOIS ANTI-INFLAMATÓRIOS E UM ANTIOXIDANTE NA PREVENÇÃO DA SENSIBILIDADE CAUSADA PELO CLAREAMENTO DENTAL
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UEPG |
Texto Completo: | http://tede2.uepg.br/jspui/handle/prefix/1832 |
Resumo: | The tooth bleaching has a long history of tooth sensitivity (TS). This study aimed to determine the effect of different drugs, administered perioperatively, on tooth sensitivity and the degree of tooth whitening after in-office bleaching. A triple-blind,parallel design, randomized clinical trial were conducted. In the first experiment, the participants received a placebo or 400 mg ibuprofen every 8 h while in the second experiment, they were given a placebo or 60 mg etoricoxib every 24 h. In the third experiment, they received a placebo or 500 mg ascorbic acid every 8 h. In all experiments, the first dose of the drug was administered 1 h before in-office bleaching and taken for a period 48 h. The 35% hydrogen peroxide gel (Whiteness HP Maxx, FGM) was used in three 15-min applications for three groups following the manufacturer's directions. The in-office bleaching agent was refreshed every 15 min.Two bleaching sessions, with a one-week interval, were performed on each patient. The shade evaluation were performed before and 30-days, after bleaching with a Vita Easy Shade spectrophotometer and a Vita Classical’s visual shade guide. The tooth sensitivity was recorded on three scales: the five-point verbal rating scale, the 101 points scale, and the visual analogue scale, of and in different time points up to 1 h, 24 h, 48h after bleaching. The % of patients that reported TS at least once during treatment were evaluated by Fisher`s exact and the intensity of tooth sensitivity with Mann-Whitney test. Tooth color changes were evaluated by repeated ANOVA measures and t-test. There were no significant differences in the % of patients with tooth sensitivity and color change between the groups. The lowest tooth sensitivity was observed in the 400 mg ibuprofen group only up to 1 h post bleaching. The perioperative use of ibuprofen, etoricoxib and ascorbic acid per oral route was not able to avoid bleaching-induced tooth sensitivity according to the posology and dose used in this study. However, the 400 mg ibuprofen was able to reduce the intensity of tooth sensitivity up to 1 h post bleaching. |
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Reis, AlessandraCPF:25713648800REIS, A.Loguércio, Alessandro DouradoCPF:38196913249http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4763905J5Santiago, Sérgio LimaCPF:38299500397http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4705306Y9Naufel, Fabiana ScarparoCPF:1544746852http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4778278H0CPF:59981229920http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4518599E6Paula, Eloisa Andrade de2017-07-24T19:22:32Z2014-06-112017-07-24T19:22:32Z2013-12-05PAULA, Eloisa Andrade de. Effect of two anti-inflammatories and one antioxidant to prevent bleaching-induced tooth sensitivity. 2013. 77 f. Tese (Doutorado em Clinica Integrada, Dentística Restauradora e Periodontia) - UNIVERSIDADE ESTADUAL DE PONTA GROSSA, Ponta Grossa, 2013.http://tede2.uepg.br/jspui/handle/prefix/1832The tooth bleaching has a long history of tooth sensitivity (TS). This study aimed to determine the effect of different drugs, administered perioperatively, on tooth sensitivity and the degree of tooth whitening after in-office bleaching. A triple-blind,parallel design, randomized clinical trial were conducted. In the first experiment, the participants received a placebo or 400 mg ibuprofen every 8 h while in the second experiment, they were given a placebo or 60 mg etoricoxib every 24 h. In the third experiment, they received a placebo or 500 mg ascorbic acid every 8 h. In all experiments, the first dose of the drug was administered 1 h before in-office bleaching and taken for a period 48 h. The 35% hydrogen peroxide gel (Whiteness HP Maxx, FGM) was used in three 15-min applications for three groups following the manufacturer's directions. The in-office bleaching agent was refreshed every 15 min.Two bleaching sessions, with a one-week interval, were performed on each patient. The shade evaluation were performed before and 30-days, after bleaching with a Vita Easy Shade spectrophotometer and a Vita Classical’s visual shade guide. The tooth sensitivity was recorded on three scales: the five-point verbal rating scale, the 101 points scale, and the visual analogue scale, of and in different time points up to 1 h, 24 h, 48h after bleaching. The % of patients that reported TS at least once during treatment were evaluated by Fisher`s exact and the intensity of tooth sensitivity with Mann-Whitney test. Tooth color changes were evaluated by repeated ANOVA measures and t-test. There were no significant differences in the % of patients with tooth sensitivity and color change between the groups. The lowest tooth sensitivity was observed in the 400 mg ibuprofen group only up to 1 h post bleaching. The perioperative use of ibuprofen, etoricoxib and ascorbic acid per oral route was not able to avoid bleaching-induced tooth sensitivity according to the posology and dose used in this study. However, the 400 mg ibuprofen was able to reduce the intensity of tooth sensitivity up to 1 h post bleaching.As técnicas de clareamento dental em dentes vitalizados podem apresentar o inconveniente de causarem sensibilidade dental. Neste estudo foram realizados três experimentos com o objetivo de determinar o efeito de dois anti-inflamatórios e um antioxidante utilizados previamente e durante o procedimento de clareamento dental em consultório na sensibilidade dental e no grau de clareamento alcançado. Estes experimentos foram do tipo estudo clínico, randomizado, paralelo, controlado por placebo e triplo cego. No experimento 1, os participantes receberam placebo ou ibuprofeno 400 mg a cada 8 h. No experimento 2, os participantes receberam placebo ou etoricoxibe 60 mg a cada 24 h. No experimento 3, os participantes receberam placebo ou ácido ascórbico 500 mg a cada 8 h. Em todos os experimentos os medicamentos foram administrados 1 hora antes do início do tratamento clareador por um período total de 48 h. Em cada sessão de clareamento, o gel de peróxido de hidrogênio 35% (Whiteness HP Maxx, FGM) foi aplicado 3 vezes durante 15 minutos cada, de acordo com as instruções do fabricante e repetido depois de uma semana, seguindo o mesmo protocolo. As alterações de cor foram avaliadas antes e 30 dias após o tratamento clareador utilizando o espectrofotômetro Vita Easy Shade e a escala de cor Vita Clássica organizada por ordem de valor. Três escalas destinadas a avaliar a intensidade da dor (escala verbal de 5 pontos, escala numérica de 101 pontos e escala visual analógica) foram utilizadas para determinar o nível de sensibilidade imediatamente até 1 h, 24 h e 48 h após o tratamento de clareamento em consultório. A porcentagem de pacientes que relataram sensibilidade, ao menos uma vez durante o tratamento, e a intensidade da sensibilidade dental foram avaliadas pelo teste exato de Fischer e teste de Mann-Whitney, respectivamente. As alterações de cor dental foram determinadas por medidas repetidas ANOVA 1 critério e teste t. Não foram detectadas diferenças significativas no percentual de pacientes que apresentaram sensibilidade e nem na alteração de cor. Somente o medicamento ibuprofeno 400 mg apresentou redução da intensidade da sensibilidade na primeira hora após o tratamento clareador. Os medicamentos não foram capazes de prevenir e nem mesmo minimizar a sensibilidade dental quando administrados de acordo com a posologia e dose empregadas neste estudo.Made available in DSpace on 2017-07-24T19:22:32Z (GMT). No. of bitstreams: 1 Eloisa Andrade de Paula.pdf: 11594237 bytes, checksum: 25299b2f989c0877ee886949439d03c9 (MD5) Previous issue date: 2013-12-05Fundação Araucária de Apoio ao Desenvolvimento Científico e Tecnológico do Paranáapplication/pdfporUNIVERSIDADE ESTADUAL DE PONTA GROSSAPrograma de Pós-Graduação em OdontologiaUEPGBRClinica Integrada, Dentística Restauradora e Periodontiaclareamento dentalensaio clínico controlado aleatóriosensibilidade da dentinaperóxido de hidrogêniotooth bleachingrandomized controlled trialdentin sensitivityhydrogen peroxideCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIAEFEITO DE DOIS ANTI-INFLAMATÓRIOS E UM ANTIOXIDANTE NA PREVENÇÃO DA SENSIBILIDADE CAUSADA PELO CLAREAMENTO DENTALEffect of two anti-inflammatories and one antioxidant to prevent bleaching-induced tooth sensitivityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UEPGinstname:Universidade Estadual de Ponta Grossa (UEPG)instacron:UEPGORIGINALEloisa Andrade de Paula.pdfapplication/pdf11594237http://tede2.uepg.br/jspui/bitstream/prefix/1832/1/Eloisa%20Andrade%20de%20Paula.pdf25299b2f989c0877ee886949439d03c9MD51prefix/18322017-07-24 16:22:32.205oai:tede2.uepg.br:prefix/1832Biblioteca Digital de Teses e Dissertaçõeshttps://tede2.uepg.br/jspui/PUBhttp://tede2.uepg.br/oai/requestbicen@uepg.br||mv_fidelis@yahoo.com.bropendoar:2017-07-24T19:22:32Biblioteca Digital de Teses e Dissertações da UEPG - Universidade Estadual de Ponta Grossa (UEPG)false |
dc.title.por.fl_str_mv |
EFEITO DE DOIS ANTI-INFLAMATÓRIOS E UM ANTIOXIDANTE NA PREVENÇÃO DA SENSIBILIDADE CAUSADA PELO CLAREAMENTO DENTAL |
dc.title.alternative.eng.fl_str_mv |
Effect of two anti-inflammatories and one antioxidant to prevent bleaching-induced tooth sensitivity |
title |
EFEITO DE DOIS ANTI-INFLAMATÓRIOS E UM ANTIOXIDANTE NA PREVENÇÃO DA SENSIBILIDADE CAUSADA PELO CLAREAMENTO DENTAL |
spellingShingle |
EFEITO DE DOIS ANTI-INFLAMATÓRIOS E UM ANTIOXIDANTE NA PREVENÇÃO DA SENSIBILIDADE CAUSADA PELO CLAREAMENTO DENTAL Paula, Eloisa Andrade de clareamento dental ensaio clínico controlado aleatório sensibilidade da dentina peróxido de hidrogênio tooth bleaching randomized controlled trial dentin sensitivity hydrogen peroxide CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
EFEITO DE DOIS ANTI-INFLAMATÓRIOS E UM ANTIOXIDANTE NA PREVENÇÃO DA SENSIBILIDADE CAUSADA PELO CLAREAMENTO DENTAL |
title_full |
EFEITO DE DOIS ANTI-INFLAMATÓRIOS E UM ANTIOXIDANTE NA PREVENÇÃO DA SENSIBILIDADE CAUSADA PELO CLAREAMENTO DENTAL |
title_fullStr |
EFEITO DE DOIS ANTI-INFLAMATÓRIOS E UM ANTIOXIDANTE NA PREVENÇÃO DA SENSIBILIDADE CAUSADA PELO CLAREAMENTO DENTAL |
title_full_unstemmed |
EFEITO DE DOIS ANTI-INFLAMATÓRIOS E UM ANTIOXIDANTE NA PREVENÇÃO DA SENSIBILIDADE CAUSADA PELO CLAREAMENTO DENTAL |
title_sort |
EFEITO DE DOIS ANTI-INFLAMATÓRIOS E UM ANTIOXIDANTE NA PREVENÇÃO DA SENSIBILIDADE CAUSADA PELO CLAREAMENTO DENTAL |
author |
Paula, Eloisa Andrade de |
author_facet |
Paula, Eloisa Andrade de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Reis, Alessandra |
dc.contributor.advisor1ID.fl_str_mv |
CPF:25713648800 |
dc.contributor.advisor1Lattes.fl_str_mv |
REIS, A. |
dc.contributor.advisor-co1.fl_str_mv |
Loguércio, Alessandro Dourado |
dc.contributor.advisor-co1ID.fl_str_mv |
CPF:38196913249 |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4763905J5 |
dc.contributor.referee1.fl_str_mv |
Santiago, Sérgio Lima |
dc.contributor.referee1ID.fl_str_mv |
CPF:38299500397 |
dc.contributor.referee1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4705306Y9 |
dc.contributor.referee2.fl_str_mv |
Naufel, Fabiana Scarparo |
dc.contributor.referee2ID.fl_str_mv |
CPF:1544746852 |
dc.contributor.referee2Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4778278H0 |
dc.contributor.authorID.fl_str_mv |
CPF:59981229920 |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4518599E6 |
dc.contributor.author.fl_str_mv |
Paula, Eloisa Andrade de |
contributor_str_mv |
Reis, Alessandra Loguércio, Alessandro Dourado Santiago, Sérgio Lima Naufel, Fabiana Scarparo |
dc.subject.por.fl_str_mv |
clareamento dental ensaio clínico controlado aleatório sensibilidade da dentina peróxido de hidrogênio |
topic |
clareamento dental ensaio clínico controlado aleatório sensibilidade da dentina peróxido de hidrogênio tooth bleaching randomized controlled trial dentin sensitivity hydrogen peroxide CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
dc.subject.eng.fl_str_mv |
tooth bleaching randomized controlled trial dentin sensitivity hydrogen peroxide |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
The tooth bleaching has a long history of tooth sensitivity (TS). This study aimed to determine the effect of different drugs, administered perioperatively, on tooth sensitivity and the degree of tooth whitening after in-office bleaching. A triple-blind,parallel design, randomized clinical trial were conducted. In the first experiment, the participants received a placebo or 400 mg ibuprofen every 8 h while in the second experiment, they were given a placebo or 60 mg etoricoxib every 24 h. In the third experiment, they received a placebo or 500 mg ascorbic acid every 8 h. In all experiments, the first dose of the drug was administered 1 h before in-office bleaching and taken for a period 48 h. The 35% hydrogen peroxide gel (Whiteness HP Maxx, FGM) was used in three 15-min applications for three groups following the manufacturer's directions. The in-office bleaching agent was refreshed every 15 min.Two bleaching sessions, with a one-week interval, were performed on each patient. The shade evaluation were performed before and 30-days, after bleaching with a Vita Easy Shade spectrophotometer and a Vita Classical’s visual shade guide. The tooth sensitivity was recorded on three scales: the five-point verbal rating scale, the 101 points scale, and the visual analogue scale, of and in different time points up to 1 h, 24 h, 48h after bleaching. The % of patients that reported TS at least once during treatment were evaluated by Fisher`s exact and the intensity of tooth sensitivity with Mann-Whitney test. Tooth color changes were evaluated by repeated ANOVA measures and t-test. There were no significant differences in the % of patients with tooth sensitivity and color change between the groups. The lowest tooth sensitivity was observed in the 400 mg ibuprofen group only up to 1 h post bleaching. The perioperative use of ibuprofen, etoricoxib and ascorbic acid per oral route was not able to avoid bleaching-induced tooth sensitivity according to the posology and dose used in this study. However, the 400 mg ibuprofen was able to reduce the intensity of tooth sensitivity up to 1 h post bleaching. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-12-05 |
dc.date.available.fl_str_mv |
2014-06-11 2017-07-24T19:22:32Z |
dc.date.accessioned.fl_str_mv |
2017-07-24T19:22:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PAULA, Eloisa Andrade de. Effect of two anti-inflammatories and one antioxidant to prevent bleaching-induced tooth sensitivity. 2013. 77 f. Tese (Doutorado em Clinica Integrada, Dentística Restauradora e Periodontia) - UNIVERSIDADE ESTADUAL DE PONTA GROSSA, Ponta Grossa, 2013. |
dc.identifier.uri.fl_str_mv |
http://tede2.uepg.br/jspui/handle/prefix/1832 |
identifier_str_mv |
PAULA, Eloisa Andrade de. Effect of two anti-inflammatories and one antioxidant to prevent bleaching-induced tooth sensitivity. 2013. 77 f. Tese (Doutorado em Clinica Integrada, Dentística Restauradora e Periodontia) - UNIVERSIDADE ESTADUAL DE PONTA GROSSA, Ponta Grossa, 2013. |
url |
http://tede2.uepg.br/jspui/handle/prefix/1832 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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UNIVERSIDADE ESTADUAL DE PONTA GROSSA |
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Programa de Pós-Graduação em Odontologia |
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UEPG |
dc.publisher.country.fl_str_mv |
BR |
dc.publisher.department.fl_str_mv |
Clinica Integrada, Dentística Restauradora e Periodontia |
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UNIVERSIDADE ESTADUAL DE PONTA GROSSA |
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reponame:Biblioteca Digital de Teses e Dissertações da UEPG instname:Universidade Estadual de Ponta Grossa (UEPG) instacron:UEPG |
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Biblioteca Digital de Teses e Dissertações da UEPG |
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Biblioteca Digital de Teses e Dissertações da UEPG - Universidade Estadual de Ponta Grossa (UEPG) |
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