Níveis elevados de IL-6 no fluido gengival de pacientes com periodontite crônica e retrocolite ulcerativa idiopática

• Autor(a) principal: Menegat, Juliana Santos Bittencourt
• Data de Publicação: 2009
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/14131
• topic: Periodontitis; Crohn s Disease; Ulcerative colitis; Interleukin-6; Periodontite; Doença de Crohn; Retrocolite ulcerativa; Interleucina-6; Crohn, Doença de; Proctocolite; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA::PERIODONTIA

Our aim was to measure the levels of interleukin-6 in gingival crevicular fluid (GCF) from patients with periodontitis and inflammatory bowel disease (IBD), and compare with systemically healthy controls with periodontitis. Besides, was measured IL-6 level in serum. Fifteen patients with Crohn s disease (CD, mean age 38.2 ± 11.4 years), 15 with ulcerative colitis (RCUI, 45.0 ± 10.5) and 15 controls (C, 42.1 ± 7.8) participated in this study. Probing pocket depth (PPD), attachment loss (CAL), presence of plaque and presence of bleeding on probing, were assessed in six sites per tooth. In each subject, GCF from four sites with gingivitis (GP- PPD≤ 3mm and CAL ≤ 1mm) and from 4 sites with periodontitis (PP- PPD ≥ 5mm and CAL ≥ 3mm), on different teeth, were collected with filter strips. The serum of those patients was also collected. The IL-6 was analyzed in the Luminex®. The total amount and the concentration of IL-6 in GCF was significantly higher in PP sites from RCUI than in controls (p=0.028 e p=0.044, respectively). The total amount of IL-6 was significantly higher in PP than GP sites in the DC group (p=0.028). In serum, IL-6 does not differ between groups. Therefore was concluded that subjects with ulcerative colitis showed higher levels of IL-6 in periodontitis sites, which might indicate an important role of this cytokine in the onset and progression of periodontal disease in such patients.