Associação entre o consumo de oxigênio e as alterações na microcirculação de pacientes pediátricos com choque séptico

• Autor(a) principal: Caixeta, Daniella Mancino da Luz
• Data de Publicação: 2015
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/12655
• topic: Microcirculation; Septic shock; Oxygen consumption; Children; Sidestream dark field (SDF) imaging; Indirect calorimetry; Cardiac index monitoring; Microcirculação; Choque séptico; Consumo de oxigênio; Pacientes pediátricos; Imagem por Sidestream dark field (SDF); Calorimetria indireta; Monitorização de índice cardíaco; Microcirculação; Choque séptico Fisiopatologia; Diagnóstico por imagem Utilização; Calorimetria indireta; Monitorização fisiológicaInstrumentação; CNPQ::CIENCIAS DA SAUDE::MEDICINA

Septic shock is characterized by the imbalance between oxygen delivery and consumption leading to tissue hypoxia. Microcirculatory dysfunction, a key element of septic shock pathogenesis, elicits maldistribution of microvascular blood flow and consenquently oxygen shunt, tissue oxygenation debt and, theoretically, impaired oxygen consumption (VO2). In this study, it was investigated if there is an association between microcirculatory changes and VO2 in pediatric patients with septic shock. Seventeen resuscitated patients with septic shock were studied in four moments (within 24hr, 48hr and 72hr of the admission or diagnosis of shock and after its resolution, prior to extubation). Sublingual microcirculation was evaluated using Sidestream dark field (SDF) imaging and VO2 was measured directly by indirect calorimetry. Other hemodynamic variables, like cardiac index, oxygen delivery, invasive arterial pressure, arterial lactate and central venous oxygen saturation were also recorded. Although global hemodynamic variables were within satisfactory ranges, microvascular variables were markedly altered, especially microvascular flow index (MFI), proportion of perfused small vessels (PPV) and perfused small vessel density (PVD). Significant associations between oxygen consumption and microcirculatory parameters were found: dVO2 and dPVD (β coefficient= 6.875; p<0.001), dVO2 and dPPV (β coefficient=92.246; p<0.001) and dVO2 and dMFI (β coefficient=21.213; p<0.001). There was no correlation between microcirculatory alterations and other variables in this study. In conclusion, this study showed that pediatric patients with septic shock presented severe microcirculatory dysfunction and abnormal microvascular blood flow could be associated to oxygen consumption.