Efeitos do treinamento em esteira em ratos obesos programados pela superalimentação pós-natal

• Autor(a) principal: Frankenfeld, Stephan Pinheiro
• Data de Publicação: 2009
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/12795
• topic: Overfeeding; Metabolic programming; Physical training; Physical capacity; Leptin; Superalimentação; Programação metabólica; Treinamento físico; Capacidade física; Leptina; CNPQ::CIENCIAS BIOLOGICAS::FISIOLOGIA::FISIOLOGIA DE ORGAOS E SISTEMAS::FISIOLOGIA ENDOCRINA

Postnatal early overnutrition is a risk factor for future obesity and metabolic disorders. Rats raised in small litters develop overweight, hyperphagia, hyperleptinemia and hypertension when adults. As chronic exercise brings well-known benefits to obese individuals, we studied the effects of training on a treadmill in adult obese rats programmed by overfeeding during lactation. To induce postnatal early overnutrition, litter size was reduced to 3 pups/litter (SL: small litter) and the groups with normal litter size (10 pups/litter) were used as control. Rats had free access to standard diet and water post weaning. At 75 days-old, animals were divided into: sedentary control (SC), trained control (TC), sedentary overfed (SO) and trained overfed (TO). We performed a test of speed to obtain the physical training prescription. From 90 until 180 days-old, TC and TO rats were trained (60min/day, 5days/week with mean speed from 50 to 65% of the acute test on a treadmill). At 90 and 180 days-old, the four experimental groups were tested for physical performance in swimming. Compared to SO, TO group at 180 days-old showed lower body weight, body adiposity (central and total), leptinaemia and corticosteronaemia. These rats presented normal values for food intake, body total protein content, HDL-c and systolic blood pressure. In addition, TO offspring displayed higher liver glycogen, total antioxidant capacity and physical capacity in the acute swimming test. Thus, we evidenced that the physical training on a treadmill was useful for revert or improve some deleterious parameters associated with metabolic syndrome observed in obese rats programmed by early postnatal overfeeding.