Efeito do extrato do açaí (Euterpe oleracea Mart) sobre as alterações cardiovasculares e metabólicas em camundongos C57BL/6 submetidos à dieta hiperlipídica.

• Autor(a) principal: Oliveira, Paola Raquel Braz de
• Data de Publicação: 2010
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/16319
• topic: Metabolic syndrome; Euterpe oleracea Mart; Mouse C57BL/6; Fat diet; Açaí Uso terapêutico; Síndrome metabólica; Dieta hiperlipídica; Plantas medicinais Uso terapêutico; Doenças cardiovasculares; Síndrome metabólica; Euterpe oleracea Mart; Camundongos C57bl/6; Dieta hiperlipídica; CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA::FARMACOLOGIA CARDIORENAL

Metabolic syndrome (MS) is a complex disorder characterized by a set of risk factors such as obesity, hypertension, hyperglycemia, insulin resistance and, dyslipidemia which predispose to a high cardiovascular morbidity and mortality. Many aspects of MS can be induced in experimental models, such as the C57BL / 6 mice by manipulating the diet offered. Among the various substances extracted from plants, the polyphenols have shown great therapeutic potential, since it reduces the incidence of cardiovascular disease and its benefits may be associated with antioxidant action, vasodilating and anti-hypertensive actions. The Euterpe oleracea Mart (açaí) is a typical plant of the tropics, and rich in polifenóis. Therefore, we evaluated the effect of Açai Stone Extract (ASE) on the cardiovascular and metabolic alterations in C57BL/6 mice fed a high-fat diet. Male mice C57BL/6, 30 days old were divided into 4 groups and received the following diets for 12 weeks: control group (C): control diet; control group + ASE (ASE + C): control diet + ASE; group hyperlipidic (H): high-fat diet, group hyperlipidic + ASE (ASE + H): high-fat diet + ASE. The following parameters were evaluated: body mass, blood pressure, vascular reactivity, plasma lipids, glucose, insulin, and lipid peroxidation in plasma. Body mass was increased in group H compared with control groups and decreased in group H + ASE compared with group H. There was no change in blood pressure among the different groups. Moreover, the reduced vasodilator effect of ACh in group H was reversed by the ASE in group H + ASE. It was also observed that the C57BL/6 mice fed a high-fat diet had hyperlipidemia, as well as hyperglycemia, hyperinsulinemia, glucose intolerance and insulin resistance and the ASE significantly reduced all these parameters. The levels of malondialdehyde (MDA) were higher in plasma samples of group H, and ASE reversed these levels in group H + ASE. The high-fat diet promotes metabolic and vascular alterations and these data together suggest that the ASE may represent an important tool for the treatment of these components that characterize MS.