Análise de marcadores biológicos em idosos portadores de síndromes demenciais residentes na região norte da cidade do Rio de Janeiro

• Autor(a) principal: Costa Neto, Ronald Ferreira da
• Data de Publicação: 2016
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/15017
• topic: Dementia; Elderly; Biomarkers; Demência; Idoso; Biomarcadores; Demência Fisiopatologia; Demência Epidemiologia; Envelhecimento; Envelhecimento Aspectos psicológicos; Idosos; Biomarcadores; CNPQ::CIENCIAS BIOLOGICAS::FISIOLOGIA::FISIOLOGIA DE ORGAOS E SISTEMAS

Dementia is a pathological condition characterized by multiple cognitive deficits that lead to impaired performance of daily social functions of an individual. The increase in its incidence relates directly to the current population aging process, generating significant impacts to global public health. The aim of the current paper is to evaluate serum concentrations levels of albumin, globulin, total protein, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase and bilirubin, searching for possible association of these analytes with dementia syndromes. Was performed a cross-sectional study with 203 participants, aged 65 or over, residing in the northern region of Rio de Janeirocity, diagnosed according to the criteria of of the Diagnostic and Statistical Manual of mental disorders (DSM-IV). Thestatistical analysis was performed using the statistical program R version 3.1.1, with significance obtained from ANOVA and Kruskal-Wallis tests. The results Analysis of the results shows significance on concentrations of albumin (p=0,001), alanine aminotransferase (p=0,002) and total bilirubin (p=0,001), although these data have not presented relevant when confronted with their own biological variation coefficients, showing thus a non-significant association between evaluated analytes and dementia in this population.