Random-Effects Models in Investigating the Effect of Vitamin A in Childhood Diarrhea

Detalhes bibliográficos
Autor(a) principal: Andreozzi, Valeska Lima
Data de Publicação: 2006
Outros Autores: Bailey, Trevor, Nobre, Flavio Fonseca, Struchiner, Claudio Jose, Barreto, Mauricio Lima, Assis, Ana Marlucia de Oliveira, Santos, Leonor Maria Pacheco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12789
Resumo: Texto completo: acesso restrito. p. 241–247
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spelling Andreozzi, Valeska LimaBailey, TrevorNobre, Flavio FonsecaStruchiner, Claudio JoseBarreto, Mauricio LimaAssis, Ana Marlucia de OliveiraSantos, Leonor Maria PachecoAndreozzi, Valeska LimaBailey, TrevorNobre, Flavio FonsecaStruchiner, Claudio JoseBarreto, Mauricio LimaAssis, Ana Marlucia de OliveiraSantos, Leonor Maria Pacheco2013-09-02T14:55:07Z20061047-2797http://www.repositorio.ufba.br/ri/handle/ri/12789v.16 n. 14Texto completo: acesso restrito. p. 241–247Purpose: By adopting more appropriate and powerful statistical methods that fully exploit longitudinal structure, we reanalyze and extend previously published results from a large community trial to investigate the effect of vitamin A supplementation on the prevalence and severity of diarrhea in young children. Methods: Generalized linear mixed models were used to allow for repeated measures in a reanalysis of a double-blind, randomized, placebo-controlled community trial conducted in a cohort of children in northeastern Brazil during 1 year. The response variable was weekly number of days with diarrhea for each child, and Markov Chain Monte Carlo methods were used to estimate model parameters. Results and conclusions: Random effects suitably accounted for the underlying heterogeneity between and within children, and our longitudinal analysis shows a significant beneficial effect of vitamin A supplementation that was inconclusive in previously reported simple summary analyses of these data. Risk for diarrhea infection was estimated to be 1.57 times greater for a child administered a placebo as opposed to vitamin A (95% credible interval, 1.17–2.12). Additionally, we identified previously unreported temporal effects in these data, showing a decreasing daily probability of diarrhea for both groups during the trial and treatment–time interaction.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-08-28T13:12:20Z No. of bitstreams: 1 1-s2.0-S1047279705003200-main.pdf: 172726 bytes, checksum: 04ce406d8e25cd7fe1438ea5cc83b717 (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-09-02T14:55:07Z (GMT) No. of bitstreams: 1 1-s2.0-S1047279705003200-main.pdf: 172726 bytes, checksum: 04ce406d8e25cd7fe1438ea5cc83b717 (MD5)Made available in DSpace on 2013-09-02T14:55:07Z (GMT). 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dc.title.pt_BR.fl_str_mv Random-Effects Models in Investigating the Effect of Vitamin A in Childhood Diarrhea
dc.title.alternative.pt_BR.fl_str_mv Annals of Epidemiology
title Random-Effects Models in Investigating the Effect of Vitamin A in Childhood Diarrhea
spellingShingle Random-Effects Models in Investigating the Effect of Vitamin A in Childhood Diarrhea
Andreozzi, Valeska Lima
Diarrhea
Vitamin A
Longitudinal Randomized Trial
Random Effects Models
title_short Random-Effects Models in Investigating the Effect of Vitamin A in Childhood Diarrhea
title_full Random-Effects Models in Investigating the Effect of Vitamin A in Childhood Diarrhea
title_fullStr Random-Effects Models in Investigating the Effect of Vitamin A in Childhood Diarrhea
title_full_unstemmed Random-Effects Models in Investigating the Effect of Vitamin A in Childhood Diarrhea
title_sort Random-Effects Models in Investigating the Effect of Vitamin A in Childhood Diarrhea
author Andreozzi, Valeska Lima
author_facet Andreozzi, Valeska Lima
Bailey, Trevor
Nobre, Flavio Fonseca
Struchiner, Claudio Jose
Barreto, Mauricio Lima
Assis, Ana Marlucia de Oliveira
Santos, Leonor Maria Pacheco
author_role author
author2 Bailey, Trevor
Nobre, Flavio Fonseca
Struchiner, Claudio Jose
Barreto, Mauricio Lima
Assis, Ana Marlucia de Oliveira
Santos, Leonor Maria Pacheco
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andreozzi, Valeska Lima
Bailey, Trevor
Nobre, Flavio Fonseca
Struchiner, Claudio Jose
Barreto, Mauricio Lima
Assis, Ana Marlucia de Oliveira
Santos, Leonor Maria Pacheco
Andreozzi, Valeska Lima
Bailey, Trevor
Nobre, Flavio Fonseca
Struchiner, Claudio Jose
Barreto, Mauricio Lima
Assis, Ana Marlucia de Oliveira
Santos, Leonor Maria Pacheco
dc.subject.por.fl_str_mv Diarrhea
Vitamin A
Longitudinal Randomized Trial
Random Effects Models
topic Diarrhea
Vitamin A
Longitudinal Randomized Trial
Random Effects Models
description Texto completo: acesso restrito. p. 241–247
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2013-09-02T14:55:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12789
dc.identifier.issn.none.fl_str_mv 1047-2797
dc.identifier.number.pt_BR.fl_str_mv v.16 n. 14
identifier_str_mv 1047-2797
v.16 n. 14
url http://www.repositorio.ufba.br/ri/handle/ri/12789
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.annepidem.2005.08.007
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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