Molecular study of HBZ and gp21 human t cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals

Detalhes bibliográficos
Autor(a) principal: Miranda, Aline Cristina A. Mota
Data de Publicação: 2013
Outros Autores: Barreto, Fernanda K., Baptista, Everton, Vale, Lourdes Farre, Cunha, Joana P. Monteiro, Castro, Bernardo Galvão, Alcântara, Luiz Carlos Júnior
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14896
Resumo: Texto completo: acesso restrito. p. 1370-1372
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spelling Miranda, Aline Cristina A. MotaBarreto, Fernanda K.Baptista, EvertonVale, Lourdes FarreCunha, Joana P. MonteiroCastro, Bernardo GalvãoAlcântara, Luiz Carlos JúniorMiranda, Aline Cristina A. MotaBarreto, Fernanda K.Baptista, EvertonVale, Lourdes FarreCunha, Joana P. MonteiroCastro, Bernardo GalvãoAlcântara, Luiz Carlos Júnior2014-05-01T13:13:06Z20130889-2229http://repositorio.ufba.br/ri/handle/ri/14896v. 29, n. 10Texto completo: acesso restrito. p. 1370-1372Human T cell leukemia virus type 1 (HTLV-1) is associated with a neurological syndrome named tropical spastic paraparesis/HTLV-associated myelopathy (TSP/HAM) and the disease progression involves viral factors. The gp21 glycoprotein is involved in envelope trafficking and membrane targeting while the bZIP protein is indispensable for cell growth and proliferation. This study aimed to assess the molecular diversity of gp21 and HBZ proteins in TSP/HAM and healthy carriers. DNA samples from HTLV-1-infected individuals were submitted to PCR and sequencing, and the molecular analyses were performed using bioinformatics tools. From eight gp21-analyzed sequences one amino acid change (Y477H) was associated with the switch of a helix to coil structure at secondary structure prediction. From 10 HBZ analyzed sequences, two amino acid changes were identified (S9P and T95I) at the activation domain. One mutation (R112C) located at the nuclear localization signal was present in 66.7% and 25% of healthy carriers (HC) and TSP/HAM groups, respectively. This is the first report of mutations in the HBZ region. These polymorphisms might be important for viral fitness.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-24T13:48:40Z No. of bitstreams: 1 aid%2E2013%2E0015.pdf: 136604 bytes, checksum: 4fe530a2831063224f021c238edeac3f (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-05-01T13:13:06Z (GMT) No. of bitstreams: 1 aid%2E2013%2E0015.pdf: 136604 bytes, checksum: 4fe530a2831063224f021c238edeac3f (MD5)Made available in DSpace on 2014-05-01T13:13:06Z (GMT). No. of bitstreams: 1 aid%2E2013%2E0015.pdf: 136604 bytes, checksum: 4fe530a2831063224f021c238edeac3f (MD5) Previous issue date: 2013http://dx.doi.org/10.1089/aid.2013.0015.reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMolecular study of HBZ and gp21 human t cell leukemia virus type 1 proteins isolated from different clinical profile infected individualsAIDS Research and Human Retrovirusesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALaid%2E2013%2E0015.pdfaid%2E2013%2E0015.pdfapplication/pdf136604https://repositorio.ufba.br/bitstream/ri/14896/1/aid%252E2013%252E0015.pdf4fe530a2831063224f021c238edeac3fMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14896/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTaid%2E2013%2E0015.pdf.txtaid%2E2013%2E0015.pdf.txtExtracted texttext/plain14841https://repositorio.ufba.br/bitstream/ri/14896/3/aid%252E2013%252E0015.pdf.txt4291f541858ce95a4c8ab29a62e4c4a5MD53ri/148962022-07-05 14:02:49.53oai:repositorio.ufba.br:ri/14896VGVybW8gZGUgTGljZW4/YSwgbj9vIGV4Y2x1c2l2bywgcGFyYSBvIGRlcD9zaXRvIG5vIFJlcG9zaXQ/cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZCQS4KCiBQZWxvIHByb2Nlc3NvIGRlIHN1Ym1pc3M/byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldSByZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIAplc3NlIHRlcm1vIGRlIGxpY2VuP2EsIGNvbmNlZGUgYW8gUmVwb3NpdD9yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSAKbyBkaXJlaXRvIGRlIG1hbnRlciB1bWEgYz9waWEgZW0gc2V1IHJlcG9zaXQ/cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCBkZSBwcmVzZXJ2YT8/by4gCkVzc2VzIHRlcm1vcywgbj9vIGV4Y2x1c2l2b3MsIG1hbnQ/bSBvcyBkaXJlaXRvcyBkZSBhdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIApjb21vIHBhcnRlIGRvIGFjZXJ2byBpbnRlbGVjdHVhbCBkZXNzYSBVbml2ZXJzaWRhZGUuCgogUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVpPz9vLCBlc3NlIHRlcm1vIGRlIGxpY2VuP2EgCmVudGVuZGUgcXVlOgoKIE1hbnRlbmRvIG9zIGRpcmVpdG9zIGF1dG9yYWlzLCByZXBhc3NhZG9zIGEgdGVyY2Vpcm9zLCBlbSBjYXNvIGRlIHB1YmxpY2E/P2VzLCBvIHJlcG9zaXQ/cmlvCnBvZGUgcmVzdHJpbmdpciBvIGFjZXNzbyBhbyB0ZXh0byBpbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1hPz9lcyBzb2JyZSBvIGRvY3VtZW50bwooTWV0YWRhZG9zIGVzY3JpdGl2b3MpLgoKIERlc3RhIGZvcm1hLCBhdGVuZGVuZG8gYW9zIGFuc2Vpb3MgZGVzc2EgdW5pdmVyc2lkYWRlIGVtIG1hbnRlciBzdWEgcHJvZHU/P28gY2llbnQ/ZmljYSBjb20gCmFzIHJlc3RyaT8/ZXMgaW1wb3N0YXMgcGVsb3MgZWRpdG9yZXMgZGUgcGVyaT9kaWNvcy4KCiBQYXJhIGFzIHB1YmxpY2E/P2VzIHNlbSBpbmljaWF0aXZhcyBxdWUgc2VndWVtIGEgcG9sP3RpY2EgZGUgQWNlc3NvIEFiZXJ0bywgb3MgZGVwP3NpdG9zIApjb21wdWxzP3Jpb3MgbmVzc2UgcmVwb3NpdD9yaW8gbWFudD9tIG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudD9tIGFjZXNzbyBpcnJlc3RyaXRvIAphbyBtZXRhZGFkb3MgZSB0ZXh0byBjb21wbGV0by4gQXNzaW0sIGEgYWNlaXRhPz9vIGRlc3NlIHRlcm1vIG4/byBuZWNlc3NpdGEgZGUgY29uc2VudGltZW50bwogcG9yIHBhcnRlIGRlIGF1dG9yZXMvZGV0ZW50b3JlcyBkb3MgZGlyZWl0b3MsIHBvciBlc3RhcmVtIGVtIGluaWNpYXRpdmFzIGRlIGFjZXNzbyBhYmVydG8uCg==Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:49Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Molecular study of HBZ and gp21 human t cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals
dc.title.alternative.pt_BR.fl_str_mv AIDS Research and Human Retroviruses
title Molecular study of HBZ and gp21 human t cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals
spellingShingle Molecular study of HBZ and gp21 human t cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals
Miranda, Aline Cristina A. Mota
title_short Molecular study of HBZ and gp21 human t cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals
title_full Molecular study of HBZ and gp21 human t cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals
title_fullStr Molecular study of HBZ and gp21 human t cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals
title_full_unstemmed Molecular study of HBZ and gp21 human t cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals
title_sort Molecular study of HBZ and gp21 human t cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals
author Miranda, Aline Cristina A. Mota
author_facet Miranda, Aline Cristina A. Mota
Barreto, Fernanda K.
Baptista, Everton
Vale, Lourdes Farre
Cunha, Joana P. Monteiro
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
author_role author
author2 Barreto, Fernanda K.
Baptista, Everton
Vale, Lourdes Farre
Cunha, Joana P. Monteiro
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Miranda, Aline Cristina A. Mota
Barreto, Fernanda K.
Baptista, Everton
Vale, Lourdes Farre
Cunha, Joana P. Monteiro
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
Miranda, Aline Cristina A. Mota
Barreto, Fernanda K.
Baptista, Everton
Vale, Lourdes Farre
Cunha, Joana P. Monteiro
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
description Texto completo: acesso restrito. p. 1370-1372
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-05-01T13:13:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14896
dc.identifier.issn.none.fl_str_mv 0889-2229
dc.identifier.number.pt_BR.fl_str_mv v. 29, n. 10
identifier_str_mv 0889-2229
v. 29, n. 10
url http://repositorio.ufba.br/ri/handle/ri/14896
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1089/aid.2013.0015.
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