Genetic Variations On IL10 Gene and Helicobacter Pylori Infection

Detalhes bibliográficos
Autor(a) principal: Assis, Shirleide
Data de Publicação: 2013
Outros Autores: Marques, Cintia R., Costa, Ryan dos Santos, Alcântara-Neves, Neuza Maria, Barreto, Mauricio Lima, Barnes, Kathleen C., Figueiredo, Camila A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/13084
Resumo: Texto completo. Acesso restrito. p. 159
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spelling Assis, ShirleideMarques, Cintia R.Costa, Ryan dos SantosAlcântara-Neves, Neuza MariaBarreto, Mauricio LimaBarnes, Kathleen C.Figueiredo, Camila A.Assis, ShirleideMarques, Cintia R.Costa, Ryan dos SantosAlcântara-Neves, Neuza MariaBarreto, Mauricio LimaBarnes, Kathleen C.Figueiredo, Camila A.2013-10-01T17:33:00Z2013-10-01T17:33:00Z20130091-6749http://www.repositorio.ufba.br/ri/handle/ri/13084v. 131, n. 2Texto completo. Acesso restrito. p. 159Rationale Helicobacter pylori (H. pylori) is a strong risk factor for gastric cancer, likely due to the extensive inflammation in the stomach mucosa caused by this bacterium. Many studies have reported the modulatory effect of H. pylori in human immune system. The aim of the study was to evaluate the association between IL10 genetic variants, H. pylori infection and IL-10 production by peripheral blood leukocytes. Methods We genotyped 12 IL10 SNPs in 1,353 children aged 4-11 years living in a poor urban area in Salvador, Brazil, using TaqMan probe based, 5’ nuclease assay minor groove binder chemistry. Association tests were performed by logistic regression for H. pylori infection and linear regression for IL-10 spontaneous production (whole blood cultures) including sex, age and principal components for informative ancestry markers as covariates, using PLINK. Results Our results shown that SNPs rs1800896 (p=0.02), rs1878672 (p=0.05) and rs3024491 (p=0.04) on IL10 gene were associated with increased H. pylori infection. The same SNPs associated to H. pylori infection were also associated with increased production of spontaneous IL-10 (p=0.04 for rs1800896, p= 0.04 for rs1878672 and p= 0.01 for rs3024491). Conclusions IL10 variants rs1800896, rs1878672 and rs3024491 increase the risk for H. pylori infection probably by its modulatory effect on IL-10 production.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-07-03T16:38:27Z No. of bitstreams: 1 222222222222.pdf: 47668 bytes, checksum: b20755c5589319d166edbcf4ce186477 (MD5)Approved for entry into archive by Maria Creuza Silva(mariakreuza@yahoo.com.br) on 2013-10-01T17:32:59Z (GMT) No. of bitstreams: 1 222222222222.pdf: 47668 bytes, checksum: b20755c5589319d166edbcf4ce186477 (MD5)Made available in DSpace on 2013-10-01T17:33:00Z (GMT). No. of bitstreams: 1 222222222222.pdf: 47668 bytes, checksum: b20755c5589319d166edbcf4ce186477 (MD5) Previous issue date: 2013SalvadorJournal of Allergy and Clinical Immunologyhttp://dx.doi.org/10.1016/j.jaci.2012.12.1230reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAGenetic Variations On IL10 Gene and Helicobacter Pylori InfectionJournal of Allergy and Clinical Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL222222222222.pdf222222222222.pdfapplication/pdf47668https://repositorio.ufba.br/bitstream/ri/13084/1/222222222222.pdfb20755c5589319d166edbcf4ce186477MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13084/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT222222222222.pdf.txt222222222222.pdf.txtExtracted texttext/plain8433https://repositorio.ufba.br/bitstream/ri/13084/3/222222222222.pdf.txt71ba7145a9d08473b848e1a58256c1cbMD53ri/130842022-08-08 13:17:34.182oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:34Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Genetic Variations On IL10 Gene and Helicobacter Pylori Infection
dc.title.alternative.pt_BR.fl_str_mv Journal of Allergy and Clinical Immunology
title Genetic Variations On IL10 Gene and Helicobacter Pylori Infection
spellingShingle Genetic Variations On IL10 Gene and Helicobacter Pylori Infection
Assis, Shirleide
title_short Genetic Variations On IL10 Gene and Helicobacter Pylori Infection
title_full Genetic Variations On IL10 Gene and Helicobacter Pylori Infection
title_fullStr Genetic Variations On IL10 Gene and Helicobacter Pylori Infection
title_full_unstemmed Genetic Variations On IL10 Gene and Helicobacter Pylori Infection
title_sort Genetic Variations On IL10 Gene and Helicobacter Pylori Infection
author Assis, Shirleide
author_facet Assis, Shirleide
Marques, Cintia R.
Costa, Ryan dos Santos
Alcântara-Neves, Neuza Maria
Barreto, Mauricio Lima
Barnes, Kathleen C.
Figueiredo, Camila A.
author_role author
author2 Marques, Cintia R.
Costa, Ryan dos Santos
Alcântara-Neves, Neuza Maria
Barreto, Mauricio Lima
Barnes, Kathleen C.
Figueiredo, Camila A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Assis, Shirleide
Marques, Cintia R.
Costa, Ryan dos Santos
Alcântara-Neves, Neuza Maria
Barreto, Mauricio Lima
Barnes, Kathleen C.
Figueiredo, Camila A.
Assis, Shirleide
Marques, Cintia R.
Costa, Ryan dos Santos
Alcântara-Neves, Neuza Maria
Barreto, Mauricio Lima
Barnes, Kathleen C.
Figueiredo, Camila A.
description Texto completo. Acesso restrito. p. 159
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-10-01T17:33:00Z
dc.date.available.fl_str_mv 2013-10-01T17:33:00Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/13084
dc.identifier.issn.none.fl_str_mv 0091-6749
dc.identifier.number.pt_BR.fl_str_mv v. 131, n. 2
identifier_str_mv 0091-6749
v. 131, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/13084
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Journal of Allergy and Clinical Immunology
publisher.none.fl_str_mv Journal of Allergy and Clinical Immunology
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.jaci.2012.12.1230
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