A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni

Detalhes bibliográficos
Autor(a) principal: Sherlock, Italo Rodrigues de Araujo
Data de Publicação: 1981
Outros Autores: Sleigh, Adrian C., Silva, J. T. França, Muniz, T. M., Mota, E. A., Barreto, Mauricio Lima, Hoff, Rodney, Maguire, J. H., Lehman, J. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5110
Resumo: p. 234 - 238
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spelling Sherlock, Italo Rodrigues de AraujoSleigh, Adrian C.Silva, J. T. FrançaMuniz, T. M.Mota, E. A.Barreto, Mauricio LimaHoff, RodneyMaguire, J. H.Lehman, J. S.Sherlock, Italo Rodrigues de AraujoSleigh, Adrian C.Silva, J. T. FrançaMuniz, T. M.Mota, E. A.Barreto, Mauricio LimaHoff, RodneyMaguire, J. H.Lehman, J. S.2012-01-11T13:31:06Z2012-01-11T13:31:06Z19810035-9203http://www.repositorio.ufba.br/ri/handle/ri/5110v. 75, n. 2.p. 234 - 238Oral oxamniquine was tested as a control strategy for endemic schistosomiasis in a rural area of Bahia, Brazil. Adults were treated with a single dose (12 * 5 to 15 mg per kg) and children ( < 12 years old) with a total of 20 mg per kg in two doses. The 191 (infected) persons treated represented 69% of the infected population in the study area. Follow-up stool examinations (Kato-Katz method) at one, 3, 6,13,25 and 33 months showed the cure rate declining from 80% at three months to 46% at 33 months. Over one half of those not cured showed a decrease in egg counts throughout the follow-up which, after 33 months, remained 66% below the pre-treatment levels. Stool examinations conducted on all study area residents during three years before chemotherapy showed the prevalence and intensity of Schistosoma mansoni infection to be high and stable. 33 months after the chemotherapy the prevalence was 41% and for infected individuals the geometric mean egg count was 121 epg, a decline of respectively 35y0 and 4074 from pre-treatment levels for each index. Chemotherapy of infected persons with oxamniquine protected the community as a whole from high worm burdens for almost three years, although at this point the prevalence began to rise towards pretreatment levels.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-01-11T13:31:06Z No. of bitstreams: 1 s2.0-0035920381903230-main.pdf: 470093 bytes, checksum: 2149b823264afefafdd02f65f1c685ec (MD5)Made available in DSpace on 2012-01-11T13:31:06Z (GMT). No. of bitstreams: 1 s2.0-0035920381903230-main.pdf: 470093 bytes, checksum: 2149b823264afefafdd02f65f1c685ec (MD5) Previous issue date: 1981A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoniTransactionso of the royal society of tropical medicine and hygieneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALs2.0-0035920381903230-main.pdfs2.0-0035920381903230-main.pdfapplication/pdf470093https://repositorio.ufba.br/bitstream/ri/5110/1/s2.0-0035920381903230-main.pdf2149b823264afefafdd02f65f1c685ecMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5110/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTs2.0-0035920381903230-main.pdf.txts2.0-0035920381903230-main.pdf.txtExtracted texttext/plain18972https://repositorio.ufba.br/bitstream/ri/5110/3/s2.0-0035920381903230-main.pdf.txte033dc4a7aaccb3feb5b56788f507b4dMD53ri/51102022-07-05 14:03:18.993oai:repositorio.ufba.br:ri/5110VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIHJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBCgogICAgUGVsbyBwcm9jZXNzbyBkZSBzdWJtaXNz77+9byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldQpyZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBjb25jZWRlIGFvClJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSBvIGRpcmVpdG8KZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCAKZGUgcHJlc2VydmHvv73vv71vLiBFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIAphdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIGNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4gCgogICAgUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVp77+977+9bywgZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEgZW50ZW5kZSBxdWU6IAoKICAgIE1hbnRlbmRvIG9zICBkaXJlaXRvcyBhdXRvcmFpcywgcmVwYXNzYWRvcyBhIHRlcmNlaXJvcywgZW0gY2FzbyAKZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8gcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIAppbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1h77+977+9ZXMgc29icmUgbyBkb2N1bWVudG8gKE1ldGFkYWRvcyBkZXNjcml0aXZvcykuCgogRGVzdGEgZm9ybWEsIGF0ZW5kZW5kbyBhb3MgYW5zZWlvcyBkZXNzYSB1bml2ZXJzaWRhZGUgCmVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gYXMgcmVzdHJp77+977+9ZXMgaW1wb3N0YXMgcGVsb3MgCmVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4gCgogICAgUGFyYSBhcyBwdWJsaWNh77+977+9ZXMgZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgCkFjZXNzbyBBYmVydG8sIG9zIGRlcO+/vXNpdG9zIGNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gCm9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudO+/vW0gbyBhY2Vzc28gaXJyZXN0cml0byBhbyBtZXRhZGFkb3MgCmUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIApjb25zZW50aW1lbnRvIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgCmVzdGFyZW0gZW0gaW5pY2lhdGl2YXMgZGUgYWNlc3NvIGFiZXJ0by4KCiAgICBFbSBhbWJvcyBvIGNhc28sIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBwb2RlIHNlciBhY2VpdG8gcGVsbyAKYXV0b3IsIGRldGVudG9yZXMgZGUgZGlyZWl0b3MgZS9vdSB0ZXJjZWlyb3MgYW1wYXJhZG9zIHBlbGEgCnVuaXZlcnNpZGFkZS4gRGV2aWRvIGFvcyBkaWZlcmVudGVzIHByb2Nlc3NvcyBwZWxvIHF1YWwgYSBzdWJtaXNz77+9byAKcG9kZSBvY29ycmVyLCBvIHJlcG9zaXTvv71yaW8gcGVybWl0ZSBhIGFjZWl0Ye+/ve+/vW8gZGEgbGljZW7vv71hIHBvciAKdGVyY2Vpcm9zLCBzb21lbnRlIG5vcyBjYXNvcyBkZSBkb2N1bWVudG9zIHByb2R1emlkb3MgcG9yIGludGVncmFudGVzIApkYSBVRkJBIGUgc3VibWV0aWRvcyBwb3IgcGVzc29hcyBhbXBhcmFkYXMgcG9yIGVzdGEgaW5zdGl0dWnvv73vv71vLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:18Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni
dc.title.alternative.pt_BR.fl_str_mv Transactionso of the royal society of tropical medicine and hygiene
title A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni
spellingShingle A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni
Sherlock, Italo Rodrigues de Araujo
title_short A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni
title_full A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni
title_fullStr A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni
title_full_unstemmed A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni
title_sort A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni
author Sherlock, Italo Rodrigues de Araujo
author_facet Sherlock, Italo Rodrigues de Araujo
Sleigh, Adrian C.
Silva, J. T. França
Muniz, T. M.
Mota, E. A.
Barreto, Mauricio Lima
Hoff, Rodney
Maguire, J. H.
Lehman, J. S.
author_role author
author2 Sleigh, Adrian C.
Silva, J. T. França
Muniz, T. M.
Mota, E. A.
Barreto, Mauricio Lima
Hoff, Rodney
Maguire, J. H.
Lehman, J. S.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sherlock, Italo Rodrigues de Araujo
Sleigh, Adrian C.
Silva, J. T. França
Muniz, T. M.
Mota, E. A.
Barreto, Mauricio Lima
Hoff, Rodney
Maguire, J. H.
Lehman, J. S.
Sherlock, Italo Rodrigues de Araujo
Sleigh, Adrian C.
Silva, J. T. França
Muniz, T. M.
Mota, E. A.
Barreto, Mauricio Lima
Hoff, Rodney
Maguire, J. H.
Lehman, J. S.
description p. 234 - 238
publishDate 1981
dc.date.issued.fl_str_mv 1981
dc.date.accessioned.fl_str_mv 2012-01-11T13:31:06Z
dc.date.available.fl_str_mv 2012-01-11T13:31:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5110
dc.identifier.issn.none.fl_str_mv 0035-9203
dc.identifier.number.pt_BR.fl_str_mv v. 75, n. 2.
identifier_str_mv 0035-9203
v. 75, n. 2.
url http://www.repositorio.ufba.br/ri/handle/ri/5110
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