Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor

Detalhes bibliográficos
Autor(a) principal: Shoemaker, Charles B.
Data de Publicação: 1992
Outros Autores: Ramachandran, Hema, Landa, Abraham, Reis, Mitermayer Galvão dos, Stein, Lincoln D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8668
Resumo: Texto completo: acesso restrito. p.17–32
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spelling Shoemaker, Charles B.Ramachandran, HemaLanda, AbrahamReis, Mitermayer Galvão dosStein, Lincoln D.Shoemaker, Charles B.Ramachandran, HemaLanda, AbrahamReis, Mitermayer Galvão dosStein, Lincoln D.2013-02-25T15:59:34Z19920166-6851http://www.repositorio.ufba.br/ri/handle/ri/8668v. 53, n. 1-2Texto completo: acesso restrito. p.17–32The complete coding DNA for a Schistosoma mansoni homologue of the epidermal growth factor receptor (SER) was characterized from cDNA clones obtained by homology to the tyrosine kinase domain of erbB. The DNA sequence predicts a 200-kDa translation product that contains a secretory leader, a cysteine-rich extracellular domain, a hydrophobic transmembrane sequence, and an intracellular tyrosine kinase domain. The SER transcript is present in cercariae and adult schistosomes. In addition to SER transcripts, schistosomes produce at least 3 variant transcripts encoding truncated SER products that include the secretory leader and a small portion of the extracellular domain followed by short sequences of unrelated, C-terminal amino acids. Based on these sequences, 2 of the variant mRNAs (class 2 and 5) appear to encode soluble, secreted proteins while one (class 4) encodes an SER variant protein with a hydrophobic C-terminus that may serve as a membrane anchor. Class 2 SER variant transcripts are present at levels comparable to SER transcripts in adult worms but are not detected in cercariae. Class 4 and 5 SER variant transcripts are also found within adult worms but at lower levels. Genomic cloning and characterization demonstrate that the variant SER transcripts arise through alternative splicing of the SER gene.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-02-22T14:24:40Z No. of bitstreams: 1 Shoemaker.pdf: 1252606 bytes, checksum: cc037e038f1e1dd1c8d3e7f7de5f334c (MD5)Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-02-25T15:59:34Z (GMT) No. of bitstreams: 1 Shoemaker.pdf: 1252606 bytes, checksum: cc037e038f1e1dd1c8d3e7f7de5f334c (MD5)Made available in DSpace on 2013-02-25T15:59:34Z (GMT). No. of bitstreams: 1 Shoemaker.pdf: 1252606 bytes, checksum: cc037e038f1e1dd1c8d3e7f7de5f334c (MD5) Previous issue date: 1992http://dx.doi.org/10.1016/0166-6851(92)90003-3reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASchistosomeSchistosoma mansoni, EGFEGF receptorAlternative splicingMembrane proteinAlternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptorMolecular and Biochemical Parasitologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8668/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINALShoemaker.pdfShoemaker.pdfapplication/pdf1252606https://repositorio.ufba.br/bitstream/ri/8668/1/Shoemaker.pdfcc037e038f1e1dd1c8d3e7f7de5f334cMD51TEXTShoemaker.pdf.txtShoemaker.pdf.txtExtracted texttext/plain59341https://repositorio.ufba.br/bitstream/ri/8668/3/Shoemaker.pdf.txt433a5d1ca793034914c6c59673550f51MD53ri/86682022-07-05 14:03:00.915oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor
dc.title.alternative.pt_BR.fl_str_mv Molecular and Biochemical Parasitology
title Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor
spellingShingle Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor
Shoemaker, Charles B.
Schistosome
Schistosoma mansoni, EGF
EGF receptor
Alternative splicing
Membrane protein
title_short Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor
title_full Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor
title_fullStr Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor
title_full_unstemmed Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor
title_sort Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor
author Shoemaker, Charles B.
author_facet Shoemaker, Charles B.
Ramachandran, Hema
Landa, Abraham
Reis, Mitermayer Galvão dos
Stein, Lincoln D.
author_role author
author2 Ramachandran, Hema
Landa, Abraham
Reis, Mitermayer Galvão dos
Stein, Lincoln D.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Shoemaker, Charles B.
Ramachandran, Hema
Landa, Abraham
Reis, Mitermayer Galvão dos
Stein, Lincoln D.
Shoemaker, Charles B.
Ramachandran, Hema
Landa, Abraham
Reis, Mitermayer Galvão dos
Stein, Lincoln D.
dc.subject.por.fl_str_mv Schistosome
Schistosoma mansoni, EGF
EGF receptor
Alternative splicing
Membrane protein
topic Schistosome
Schistosoma mansoni, EGF
EGF receptor
Alternative splicing
Membrane protein
description Texto completo: acesso restrito. p.17–32
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2013-02-25T15:59:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8668
dc.identifier.issn.none.fl_str_mv 0166-6851
dc.identifier.number.pt_BR.fl_str_mv v. 53, n. 1-2
identifier_str_mv 0166-6851
v. 53, n. 1-2
url http://www.repositorio.ufba.br/ri/handle/ri/8668
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/0166-6851(92)90003-3
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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