Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil

Detalhes bibliográficos
Autor(a) principal: Santana, Nelma Pereira de
Data de Publicação: 2005
Outros Autores: Freitas, Luiz A. R. de, Lyra, André Castro, Paraná, Raymundo, Santana, Genoile, Trepo, Christian, Lyra, Luiz Guilherme Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6986
Resumo: p. 134-141
id UFBA-2_0bf891ca339f444d2980ca8792cff86d
oai_identifier_str oai:repositorio.ufba.br:ri/6986
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Santana, Nelma Pereira deFreitas, Luiz A. R. deLyra, André CastroParaná, RaymundoSantana, GenoileTrepo, ChristianLyra, Luiz Guilherme CostaSantana, Nelma Pereira deFreitas, Luiz A. R. deLyra, André CastroParaná, RaymundoSantana, GenoileTrepo, ChristianLyra, Luiz Guilherme Costa2012-10-17T18:11:24Z2012-10-17T18:11:24Z20051413-8670http://www.repositorio.ufba.br/ri/handle/ri/6986v. 9, n. 2p. 134-141Patients with chronic hepatitis C can have variable clinical progression. Hepatic histological alterations appear to be milder in asymptomatic subjects who have persistently normal ALT levels. AIMS: To evaluate the severity of histological liver alterations in blood donors with normal and elevated ALT levels. METHODS: We evaluated volunteer blood donors from the main blood bank of the city of Salvador-Brazil. Those who were anti-HCV positive were invited to participate in the study. Serum ALT and AST levels were measured at two time points, two months apart. Donors were divided into two groups: group I, individuals with ALT > 1.5 times the upper limit of normal in at least one time point and group II, individuals with normal or near normal ALT, at both time points RESULTS: We evaluated 30,232 blood donors and 528 (1.7%) of them were anti-HCV positive. Eighty-two attended our service and HCV infection was confirmed in 66 individuals. Male gender predominated in both groups; the mean age was 36 for group I, and 33 for group II. Tattoos and intravenous illicit drug use were frequently-encountered risk factors. Liver biopsy was done in 43 subjects. Among donors with elevated ALT, two (10%) had minimum alterations, while in group II normal liver or minimum alterations were observed in six (26%) subjects. Chronic hepatitis or cirrhosis was encountered in 35 (81%) individuals: three (15%) and five (21%) subjects had chronic hepatitis without inflammatory activity, 10 (50%) and 11 (48%) had minimum to moderate activity and five (25%) and one (4.3%) had cirrhosis, in groups I and II, respectively (P was not significant). CONCLUSIONS: The prevalence of anti-HCV among this population of volunteer blood donors was 1.7%, and these subjects had few liver histological alterations or chronic hepatitis and cirrhosis. Liver injury severity was significant in patients with elevated ALT, however subjects with normal levels may also present chronic hepatitis and cirrhosis.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-10-17T18:11:24Z No. of bitstreams: 1 Santana, Nelma Pereira de.pdf: 117489 bytes, checksum: ae2c35cd1681fc7a9728f771c2c32d94 (MD5)Made available in DSpace on 2012-10-17T18:11:24Z (GMT). No. of bitstreams: 1 Santana, Nelma Pereira de.pdf: 117489 bytes, checksum: ae2c35cd1681fc7a9728f771c2c32d94 (MD5) Previous issue date: 2005SalvadorBrazilian Journal of Infectious Diseaseshttp://dx.doi.org/10.1590/S1413-86702005000200003reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAALT levelsliver alterationsHCVNortheast-BrazilLiver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-BrazilBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1809https://repositorio.ufba.br/bitstream/ri/6986/2/license.txt8bb3e3eb871f5854a9ec419f68651b60MD52ORIGINALSantana, Nelma Pereira de.pdfSantana, Nelma Pereira de.pdfapplication/pdf117489https://repositorio.ufba.br/bitstream/ri/6986/1/Santana%2c%20Nelma%20Pereira%20de.pdfae2c35cd1681fc7a9728f771c2c32d94MD51TEXTSantana, Nelma Pereira de.pdf.txtSantana, Nelma Pereira de.pdf.txtExtracted texttext/plain25898https://repositorio.ufba.br/bitstream/ri/6986/3/Santana%2c%20Nelma%20Pereira%20de.pdf.txtc56d8a9aea967562a18843736be176e9MD53ri/69862022-07-05 14:02:54.681oai:repositorio.ufba.br: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ório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:54Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Infectious Diseases
title Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
spellingShingle Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
Santana, Nelma Pereira de
ALT levels
liver alterations
HCV
Northeast-Brazil
title_short Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
title_full Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
title_fullStr Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
title_full_unstemmed Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
title_sort Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
author Santana, Nelma Pereira de
author_facet Santana, Nelma Pereira de
Freitas, Luiz A. R. de
Lyra, André Castro
Paraná, Raymundo
Santana, Genoile
Trepo, Christian
Lyra, Luiz Guilherme Costa
author_role author
author2 Freitas, Luiz A. R. de
Lyra, André Castro
Paraná, Raymundo
Santana, Genoile
Trepo, Christian
Lyra, Luiz Guilherme Costa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santana, Nelma Pereira de
Freitas, Luiz A. R. de
Lyra, André Castro
Paraná, Raymundo
Santana, Genoile
Trepo, Christian
Lyra, Luiz Guilherme Costa
Santana, Nelma Pereira de
Freitas, Luiz A. R. de
Lyra, André Castro
Paraná, Raymundo
Santana, Genoile
Trepo, Christian
Lyra, Luiz Guilherme Costa
dc.subject.por.fl_str_mv ALT levels
liver alterations
HCV
Northeast-Brazil
topic ALT levels
liver alterations
HCV
Northeast-Brazil
description p. 134-141
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2012-10-17T18:11:24Z
dc.date.available.fl_str_mv 2012-10-17T18:11:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6986
dc.identifier.issn.none.fl_str_mv 1413-8670
dc.identifier.number.pt_BR.fl_str_mv v. 9, n. 2
identifier_str_mv 1413-8670
v. 9, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/6986
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Brazilian Journal of Infectious Diseases
publisher.none.fl_str_mv Brazilian Journal of Infectious Diseases
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S1413-86702005000200003
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/6986/2/license.txt
https://repositorio.ufba.br/bitstream/ri/6986/1/Santana%2c%20Nelma%20Pereira%20de.pdf
https://repositorio.ufba.br/bitstream/ri/6986/3/Santana%2c%20Nelma%20Pereira%20de.pdf.txt
bitstream.checksum.fl_str_mv 8bb3e3eb871f5854a9ec419f68651b60
ae2c35cd1681fc7a9728f771c2c32d94
c56d8a9aea967562a18843736be176e9
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459408648175616

Registros relacionados