Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity

Detalhes bibliográficos
Autor(a) principal: Endara, P.
Data de Publicação: 2010
Outros Autores: Vaca-Martínez, Gioconda Maritza, Chico, M. E., Erazo, Silvia, Oviedo, G., Moncayo, A. L., Rodriguez, A., Barreto, Mauricio Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12163
Resumo: Texto completo: acesso restrito. p.1669–1677
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spelling Endara, P.Vaca-Martínez, Gioconda MaritzaChico, M. E.Erazo, SilviaOviedo, G.Moncayo, A. L.Rodriguez, A.Barreto, Mauricio LimaEndara, P.Vaca-Martínez, Gioconda MaritzaChico, M. E.Erazo, SilviaOviedo, G.Moncayo, A. L.Rodriguez, A.Barreto, Mauricio Lima2013-07-10T16:08:42Z20100954-7894http://www.repositorio.ufba.br/ri/handle/ri/12163v. 40, n. 11Texto completo: acesso restrito. p.1669–1677Background The low prevalence of allergic disease in the rural tropics has been attributed to the protective effects of chronic helminth infections. There is concern that treatment-based control programmes for these parasites may lead to an increase in the prevalence of allergic diseases. Objective We measured the impact of 15–17 years of anthelmintic treatment with ivermectin on the prevalence of allergen skin test reactivity and allergic symptoms in school-age children. Methods The prevalence of allergen skin test reactivity, exercise-induced bronchospasm and allergic symptoms was compared between school-age children living in communities that had received community-based treatments with ivermectin (for onchocerciasis control) for a period of 15–17 years with those living in geographically adjacent communities that had received no ivermectin. Results The prevalence of allergen skin test reactivity was double in children living in treated communities compared with those in untreated communities (16.7% vs. 8.7%, adjusted OR 2.10, 95% CI 1.50–2.94, P<0.0001), and the effect was mediated partly by a reduced prevalence of Trichuris trichiura among treated children. Ivermectin treatments were associated with an increased prevalence of recent eczema symptoms (adjusted OR 2.24, 95% CI 1.05–4.78, P=0.04) but not symptoms of asthma or rhino-conjunctivitis. The effect on eczema symptoms was not associated with reductions in geohelminth infections. Conclusion Long-term periodic treatments with ivermectin were associated with an increased prevalence of allergen skin test reactivity. There was some evidence that treatment was associated with an increased prevalence of recent eczema symptoms but not those of asthma or rhino-conjunctivitis.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-07-10T16:08:41Z No. of bitstreams: 1 j.1365-2222.2010.03559.x.pdf: 154911 bytes, checksum: 7d6edc105dabae3c03451053d655aa2c (MD5)Made available in DSpace on 2013-07-10T16:08:42Z (GMT). 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dc.title.pt_BR.fl_str_mv Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity
dc.title.alternative.pt_BR.fl_str_mv Clinical and Experimental Allergy
title Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity
spellingShingle Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity
Endara, P.
Allergen skin reactivity
Geohelminths
Ivermectin
title_short Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity
title_full Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity
title_fullStr Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity
title_full_unstemmed Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity
title_sort Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity
author Endara, P.
author_facet Endara, P.
Vaca-Martínez, Gioconda Maritza
Chico, M. E.
Erazo, Silvia
Oviedo, G.
Moncayo, A. L.
Rodriguez, A.
Barreto, Mauricio Lima
author_role author
author2 Vaca-Martínez, Gioconda Maritza
Chico, M. E.
Erazo, Silvia
Oviedo, G.
Moncayo, A. L.
Rodriguez, A.
Barreto, Mauricio Lima
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Endara, P.
Vaca-Martínez, Gioconda Maritza
Chico, M. E.
Erazo, Silvia
Oviedo, G.
Moncayo, A. L.
Rodriguez, A.
Barreto, Mauricio Lima
Endara, P.
Vaca-Martínez, Gioconda Maritza
Chico, M. E.
Erazo, Silvia
Oviedo, G.
Moncayo, A. L.
Rodriguez, A.
Barreto, Mauricio Lima
dc.subject.por.fl_str_mv Allergen skin reactivity
Geohelminths
Ivermectin
topic Allergen skin reactivity
Geohelminths
Ivermectin
description Texto completo: acesso restrito. p.1669–1677
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-07-10T16:08:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12163
dc.identifier.issn.none.fl_str_mv 0954-7894
dc.identifier.number.pt_BR.fl_str_mv v. 40, n. 11
identifier_str_mv 0954-7894
v. 40, n. 11
url http://www.repositorio.ufba.br/ri/handle/ri/12163
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1111/j.1365-2222.2010.03559.x
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