Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood

Detalhes bibliográficos
Autor(a) principal: Rodrigues, L. C.
Data de Publicação: 2008
Outros Autores: Newcombe, P. J., Cunha, Sérgio Souza da, Alcântara-Neves, Neuza Maria, Genserw, B., Cruz Filho, Álvaro Augusto Souza da, Simoes, S. M., Fiaccone, R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6002
Resumo: Acesso restrito: Texto completo. p. 1769-1777
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spelling Rodrigues, L. C.Newcombe, P. J.Cunha, Sérgio Souza daAlcântara-Neves, Neuza MariaGenserw, B.Cruz Filho, Álvaro Augusto Souza daSimoes, S. M.Fiaccone, R.Rodrigues, L. C.Newcombe, P. J.Cunha, Sérgio Souza daAlcântara-Neves, Neuza MariaGenserw, B.Cruz Filho, Álvaro Augusto Souza daSimoes, S. M.Fiaccone, R.2012-05-30T19:35:34Z20080954-7894http://www.repositorio.ufba.br/ri/handle/ri/6002v. 38 , n. 11Acesso restrito: Texto completo. p. 1769-1777Background Allergic diseases cause a large and increasing burden in developed countries and in urban centres in middle-income countries. The causes of this increase are unknown and,currently, there are no interventions to prevent the development of allergic diseases. The‘hygiene hypothesis’ has tried to explain the increase through a reduction in the frequency of childhood infections causing a failure to program the immune system for adequate immune regulation. Intestinal helminth parasites are prevalent in childhood in developing countries and are associated with a lower prevalence of allergen skin test reactivity and asthma.Objectives To investigate whether children who had intestinal helminth infections during early childhood have a lower prevalence of allergen skin test reactivity later in childhood. Methods We re-visited a population of 1055 children from whom stool samples had been collected for detection of intestinal helminth infections for another study, and collected new stool samples and performed allergen skin prick testing. Information on potential confounding variables was collected. Results Children with heavy infections with Trichuris trichiura in early childhood had a significantly reduced prevalence of allergen skin test reactivity in later childhood, even in the absence of T. trichiura infection at the time of skin testing in later childhood. Conclusion Early heavy infections with T. trichiura may protect against the development of allergen skin test reactivity in later childhood. Novel treatments to program immuneregulation in early childhood in a way that mimics the effects of early infections with T. trichiura may offer new strategies for the prevention of allergic disease.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-30T19:35:34Z No. of bitstreams: 1 __onlinelibrary.wiley.co...b6e10a7b94a463a9cf267e9ddc86d.pdf: 139922 bytes, checksum: 7326419cb2a46e8c4b9fc67061cd3c8c (MD5)Made available in DSpace on 2012-05-30T19:35:34Z (GMT). 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dc.title.pt_BR.fl_str_mv Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood
dc.title.alternative.pt_BR.fl_str_mv Clinical and Experimental Allergy
title Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood
spellingShingle Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood
Rodrigues, L. C.
allergen skin test reactivity
asthma
atopy
immune programming
intestinal helminths
rhinitis
Trichuris trichiura
title_short Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood
title_full Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood
title_fullStr Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood
title_full_unstemmed Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood
title_sort Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood
author Rodrigues, L. C.
author_facet Rodrigues, L. C.
Newcombe, P. J.
Cunha, Sérgio Souza da
Alcântara-Neves, Neuza Maria
Genserw, B.
Cruz Filho, Álvaro Augusto Souza da
Simoes, S. M.
Fiaccone, R.
author_role author
author2 Newcombe, P. J.
Cunha, Sérgio Souza da
Alcântara-Neves, Neuza Maria
Genserw, B.
Cruz Filho, Álvaro Augusto Souza da
Simoes, S. M.
Fiaccone, R.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, L. C.
Newcombe, P. J.
Cunha, Sérgio Souza da
Alcântara-Neves, Neuza Maria
Genserw, B.
Cruz Filho, Álvaro Augusto Souza da
Simoes, S. M.
Fiaccone, R.
Rodrigues, L. C.
Newcombe, P. J.
Cunha, Sérgio Souza da
Alcântara-Neves, Neuza Maria
Genserw, B.
Cruz Filho, Álvaro Augusto Souza da
Simoes, S. M.
Fiaccone, R.
dc.subject.por.fl_str_mv allergen skin test reactivity
asthma
atopy
immune programming
intestinal helminths
rhinitis
Trichuris trichiura
topic allergen skin test reactivity
asthma
atopy
immune programming
intestinal helminths
rhinitis
Trichuris trichiura
description Acesso restrito: Texto completo. p. 1769-1777
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-05-30T19:35:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6002
dc.identifier.issn.none.fl_str_mv 0954-7894
dc.identifier.number.pt_BR.fl_str_mv v. 38 , n. 11
identifier_str_mv 0954-7894
v. 38 , n. 11
url http://www.repositorio.ufba.br/ri/handle/ri/6002
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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