Hypercalcemia and acute kidney injury caused by abuse of a parenteral veterinary compound containing vitamins A, D, and E

Detalhes bibliográficos
Autor(a) principal: Rocha, Paulo Novis
Data de Publicação: 2011
Outros Autores: Santos, Caroline Sancho, Avila, Maria Olinda, Neves, Carolina Lara, Oliveira, Marilia Bahiense
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16725
Resumo: Texto completo: acesso restrito. p. 467-471
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spelling Rocha, Paulo NovisSantos, Caroline SanchoAvila, Maria OlindaNeves, Carolina LaraOliveira, Marilia BahienseRocha, Paulo NovisSantos, Caroline SanchoAvila, Maria OlindaNeves, Carolina LaraOliveira, Marilia Bahiense2014-12-15T16:55:03Z2014-12-15T16:55:03Z20110101-2800http://repositorio.ufba.br/ri/handle/ri/16725v. 33, n. 4Texto completo: acesso restrito. p. 467-471A previously healthy 19 year-old male presented to the hospital with anorexia, nausea, and vomiting. Laboratory studies were significant for hypercalcemia (peak calcium value of 14.8 mg/dL) and acute kidney injury (peak serum creatinine of 2.88 mg/dL). He admitted to using a parenteral formulation of vitamins A, D and E restricted for veterinary use containing 20,000,000 IU of vitamin A; 5,000,000 IU of vitamin D3; and 6,800 IU of vitamin E per 100 mL vial. The patient stated to have used close to 300 mL of the product over the preceding year. Interestingly, the young man was not interested in the massive amounts of vitamins that the product contained; he was only after the local effects of the oily vehicle. The swelling produced by the injection resulted in a silicone-like effect, which gave the impression of bigger muscles. Nevertheless, the product was absorbed and caused hypervitaminosis. The serum level of 25(OH) vitamin D was clearly elevated at 150 ng/mL (reference range from 30 to 60 ng/mL), but in most published cases of vitamin D toxicity, serum levels have been well above 200 ng/mL. His PTH level was undetectable and other potential causes of hypercalcemia were excluded. Therefore, we posit that the severity of the hypercalcemia observed in this case was the result of a synergistic effect of vitamins A and D. The patient was treated with normal saline, furosemide and zolendronic acid, with rapid normalization of calcium levels and renal function.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-02-18T14:13:59Z No. of bitstreams: 1 Paulo Novis Rocha.pdf: 136118 bytes, checksum: 34c871810fae439c027b8bfcffbe8cd7 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-12-15T16:55:03Z (GMT) No. of bitstreams: 1 Paulo Novis Rocha.pdf: 136118 bytes, checksum: 34c871810fae439c027b8bfcffbe8cd7 (MD5)Made available in DSpace on 2014-12-15T16:55:03Z (GMT). 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dc.title.pt_BR.fl_str_mv Hypercalcemia and acute kidney injury caused by abuse of a parenteral veterinary compound containing vitamins A, D, and E
dc.title.alternative.pt_BR.fl_str_mv Jornal Brasileiro de Nefrologia
title Hypercalcemia and acute kidney injury caused by abuse of a parenteral veterinary compound containing vitamins A, D, and E
spellingShingle Hypercalcemia and acute kidney injury caused by abuse of a parenteral veterinary compound containing vitamins A, D, and E
Rocha, Paulo Novis
25-hydroxyvitamin D 2
Vitamin A
Overdose
Hypercalcemia
Acute kidney injury
title_short Hypercalcemia and acute kidney injury caused by abuse of a parenteral veterinary compound containing vitamins A, D, and E
title_full Hypercalcemia and acute kidney injury caused by abuse of a parenteral veterinary compound containing vitamins A, D, and E
title_fullStr Hypercalcemia and acute kidney injury caused by abuse of a parenteral veterinary compound containing vitamins A, D, and E
title_full_unstemmed Hypercalcemia and acute kidney injury caused by abuse of a parenteral veterinary compound containing vitamins A, D, and E
title_sort Hypercalcemia and acute kidney injury caused by abuse of a parenteral veterinary compound containing vitamins A, D, and E
author Rocha, Paulo Novis
author_facet Rocha, Paulo Novis
Santos, Caroline Sancho
Avila, Maria Olinda
Neves, Carolina Lara
Oliveira, Marilia Bahiense
author_role author
author2 Santos, Caroline Sancho
Avila, Maria Olinda
Neves, Carolina Lara
Oliveira, Marilia Bahiense
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rocha, Paulo Novis
Santos, Caroline Sancho
Avila, Maria Olinda
Neves, Carolina Lara
Oliveira, Marilia Bahiense
Rocha, Paulo Novis
Santos, Caroline Sancho
Avila, Maria Olinda
Neves, Carolina Lara
Oliveira, Marilia Bahiense
dc.subject.por.fl_str_mv 25-hydroxyvitamin D 2
Vitamin A
Overdose
Hypercalcemia
Acute kidney injury
topic 25-hydroxyvitamin D 2
Vitamin A
Overdose
Hypercalcemia
Acute kidney injury
description Texto completo: acesso restrito. p. 467-471
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-12-15T16:55:03Z
dc.date.available.fl_str_mv 2014-12-15T16:55:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16725
dc.identifier.issn.none.fl_str_mv 0101-2800
dc.identifier.number.pt_BR.fl_str_mv v. 33, n. 4
identifier_str_mv 0101-2800
v. 33, n. 4
url http://repositorio.ufba.br/ri/handle/ri/16725
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0101-28002011000400013
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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