Infectivity of leishmania promastigotes is associated with surface antigenic expression

Detalhes bibliográficos
Autor(a) principal: Sherlock, Italo Rodrigues de Araujo
Data de Publicação: 1985
Outros Autores: Rizvi, Farrukh S., Afchain, Daniel, Sadigursky, Moyses
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5114
Resumo: p.317-323
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spelling Sherlock, Italo Rodrigues de AraujoRizvi, Farrukh S.Afchain, DanielSadigursky, MoysesSherlock, Italo Rodrigues de AraujoRizvi, Farrukh S.Afchain, DanielSadigursky, Moyses2012-01-11T13:53:38Z2012-01-11T13:53:38Z19850165-2478http://www.repositorio.ufba.br/ri/handle/ri/5114v. 11p.317-323Differentiation between a non-infective and an infective Leishrnania promastigote population was demonstrated. Promastigotes in the stationary phase (day 5) were found to be highly infective in vitro to BALB/c mouse peritoneal macrophages, compared with those of the logarithmic phase (day 3). The infective promastigotes showed surface antigenic determinants different from non-infective ones. Polyclonal anti-3 day and anti-5 day antibodies were bound specifically to the surface of corresponding promastigotes in both SRIA and IFAT; no strong cross-reactions were observed otherwise. Also, polyclonal anti-5 day but not anti-3 day antibodies recognized efficiently the antigenic molecules on the surface of late stage (day 7) sandfly promastigotes. This clearly indicates the appearance of new antigenic molecules on the surface of infective promastigote forms. Intracellular multiplication of Leishmania was significantly inhibited by anti-5 day antibodies compared with anti-3 day antibodies. The presence of new surface molecules on late stage promastigotes may contribute to Leishmania infectivity.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-01-11T13:53:38Z No. of bitstreams: 1 s2.0-0165247885901142-main.pdf: 510366 bytes, checksum: 6c8a095ce82196803a231bde3e90fcae (MD5)Made available in DSpace on 2012-01-11T13:53:38Z (GMT). No. of bitstreams: 1 s2.0-0165247885901142-main.pdf: 510366 bytes, checksum: 6c8a095ce82196803a231bde3e90fcae (MD5) Previous issue date: 1985Leishmaniamacrophage interactionsinfectivitysurface antigenic expressionpolyclonal antibodiesInfectivity of leishmania promastigotes is associated with surface antigenic expressionImmunology Lettersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALs2.0-0165247885901142-main.pdfs2.0-0165247885901142-main.pdfapplication/pdf510366https://repositorio.ufba.br/bitstream/ri/5114/1/s2.0-0165247885901142-main.pdf6c8a095ce82196803a231bde3e90fcaeMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5114/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTs2.0-0165247885901142-main.pdf.txts2.0-0165247885901142-main.pdf.txtExtracted texttext/plain23691https://repositorio.ufba.br/bitstream/ri/5114/3/s2.0-0165247885901142-main.pdf.txtc058f89d0ea529434adfe572546b852dMD53ri/51142022-07-05 14:03:51.775oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Infectivity of leishmania promastigotes is associated with surface antigenic expression
dc.title.alternative.pt_BR.fl_str_mv Immunology Letters
title Infectivity of leishmania promastigotes is associated with surface antigenic expression
spellingShingle Infectivity of leishmania promastigotes is associated with surface antigenic expression
Sherlock, Italo Rodrigues de Araujo
Leishmania
macrophage interactions
infectivity
surface antigenic expression
polyclonal antibodies
title_short Infectivity of leishmania promastigotes is associated with surface antigenic expression
title_full Infectivity of leishmania promastigotes is associated with surface antigenic expression
title_fullStr Infectivity of leishmania promastigotes is associated with surface antigenic expression
title_full_unstemmed Infectivity of leishmania promastigotes is associated with surface antigenic expression
title_sort Infectivity of leishmania promastigotes is associated with surface antigenic expression
author Sherlock, Italo Rodrigues de Araujo
author_facet Sherlock, Italo Rodrigues de Araujo
Rizvi, Farrukh S.
Afchain, Daniel
Sadigursky, Moyses
author_role author
author2 Rizvi, Farrukh S.
Afchain, Daniel
Sadigursky, Moyses
author2_role author
author
author
dc.contributor.author.fl_str_mv Sherlock, Italo Rodrigues de Araujo
Rizvi, Farrukh S.
Afchain, Daniel
Sadigursky, Moyses
Sherlock, Italo Rodrigues de Araujo
Rizvi, Farrukh S.
Afchain, Daniel
Sadigursky, Moyses
dc.subject.por.fl_str_mv Leishmania
macrophage interactions
infectivity
surface antigenic expression
polyclonal antibodies
topic Leishmania
macrophage interactions
infectivity
surface antigenic expression
polyclonal antibodies
description p.317-323
publishDate 1985
dc.date.issued.fl_str_mv 1985
dc.date.accessioned.fl_str_mv 2012-01-11T13:53:38Z
dc.date.available.fl_str_mv 2012-01-11T13:53:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5114
dc.identifier.issn.none.fl_str_mv 0165-2478
dc.identifier.number.pt_BR.fl_str_mv v. 11
identifier_str_mv 0165-2478
v. 11
url http://www.repositorio.ufba.br/ri/handle/ri/5114
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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