Miltefosine in the treatment of cutaneous leishmaniasis caused by leishmania braziliensis in Brazil: a randomized and controlled trial
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12312 |
Resumo: | p. 1-6 |
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Machado, Paulo Roberto LimaAmpuero, JuliaGuimarães, Luiz H.Villasboas, LeonardoRocha, Ana T.Schriefer, Nicolaus Albert BorgesSousa, Rosana SantosTalhari, Anette ChrusciakPenna, Gerson de OliveiraCarvalho Filho, Edgar Marcelino deMachado, Paulo Roberto LimaAmpuero, JuliaGuimarães, Luiz H.Villasboas, LeonardoRocha, Ana T.Schriefer, Nicolaus Albert BorgesSousa, Rosana SantosTalhari, Anette ChrusciakPenna, Gerson de OliveiraCarvalho Filho, Edgar Marcelino de2013-07-26T17:45:15Z2013-07-26T17:45:15Z2010-121935-2727http://www.repositorio.ufba.br/ri/handle/ri/12312v. 4, n. 12p. 1-6Background: Cutaneous leishmaniasis (CL) is treated with parenteral drugs for decades with decreasing rate cures. Miltefosine is an oral medication with anti-leishmania activity and may increase the cure rates and improve compliance. Methodology/Principal Findings: This study is a randomized, open-label, controlled clinical trial aimed to evaluate the efficacy and safety of miltefosine versus pentavalent antimony (Sbv) in the treatment of patients with CL caused by Leishmania braziliensis in Bahia, Brazil. A total of 90 patients were enrolled in the trial; 60 were assigned to receive miltefosine and 30 to receive Sbv. Six months after treatment, in the intention-to-treat analyses, the definitive cure rate was 53.3% in the Sbv group and 75% in the miltefosine group (difference of 21.7%, 95% CI 0.08% to 42.7%, p = 0.04). Miltefosine was more effective than Sbv in the age group of 13–65 years-old compared to 2–12 years-old group (78.9% versus 45% p = 0.02; 68.2% versus 70% p = 1.0, respectively). The incidence of adverse events was similar in the Sbv and miltefosine groups (76.7% vs. 78.3%). Vomiting (41.7%), nausea (40%), and abdominal pain (23.3%) were significantly more frequent in the miltefosine group while arthralgias (20.7%), mialgias (20.7%) and fever (23.3%) were significantly more frequent in the Sbv group. Conclusions: This study demonstrates that miltefosine therapy is more effective than standard Sbv and safe for the treatment of CL caused by Leishmania braziliensis in Bahia, Brazil.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-07-03T13:59:32Z No. of bitstreams: 1 Paulo Machado.pdf: 352428 bytes, checksum: cfe1f635c04f20b83a6a736653504555 (MD5)Approved for entry into archive by Sales José Carlos(postalsalles@yahoo.com.br) on 2013-07-26T17:45:15Z (GMT) No. of bitstreams: 1 Paulo Machado.pdf: 352428 bytes, checksum: cfe1f635c04f20b83a6a736653504555 (MD5)Made available in DSpace on 2013-07-26T17:45:15Z (GMT). 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| dc.title.pt_BR.fl_str_mv |
Miltefosine in the treatment of cutaneous leishmaniasis caused by leishmania braziliensis in Brazil: a randomized and controlled trial |
| dc.title.alternative.pt_BR.fl_str_mv |
PLoS Neglected Tropical Diseases |
| title |
Miltefosine in the treatment of cutaneous leishmaniasis caused by leishmania braziliensis in Brazil: a randomized and controlled trial |
| spellingShingle |
Miltefosine in the treatment of cutaneous leishmaniasis caused by leishmania braziliensis in Brazil: a randomized and controlled trial Machado, Paulo Roberto Lima |
| title_short |
Miltefosine in the treatment of cutaneous leishmaniasis caused by leishmania braziliensis in Brazil: a randomized and controlled trial |
| title_full |
Miltefosine in the treatment of cutaneous leishmaniasis caused by leishmania braziliensis in Brazil: a randomized and controlled trial |
| title_fullStr |
Miltefosine in the treatment of cutaneous leishmaniasis caused by leishmania braziliensis in Brazil: a randomized and controlled trial |
| title_full_unstemmed |
Miltefosine in the treatment of cutaneous leishmaniasis caused by leishmania braziliensis in Brazil: a randomized and controlled trial |
| title_sort |
Miltefosine in the treatment of cutaneous leishmaniasis caused by leishmania braziliensis in Brazil: a randomized and controlled trial |
| author |
Machado, Paulo Roberto Lima |
| author_facet |
Machado, Paulo Roberto Lima Ampuero, Julia Guimarães, Luiz H. Villasboas, Leonardo Rocha, Ana T. Schriefer, Nicolaus Albert Borges Sousa, Rosana Santos Talhari, Anette Chrusciak Penna, Gerson de Oliveira Carvalho Filho, Edgar Marcelino de |
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author |
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Ampuero, Julia Guimarães, Luiz H. Villasboas, Leonardo Rocha, Ana T. Schriefer, Nicolaus Albert Borges Sousa, Rosana Santos Talhari, Anette Chrusciak Penna, Gerson de Oliveira Carvalho Filho, Edgar Marcelino de |
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author author author author author author author author author |
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Machado, Paulo Roberto Lima Ampuero, Julia Guimarães, Luiz H. Villasboas, Leonardo Rocha, Ana T. Schriefer, Nicolaus Albert Borges Sousa, Rosana Santos Talhari, Anette Chrusciak Penna, Gerson de Oliveira Carvalho Filho, Edgar Marcelino de Machado, Paulo Roberto Lima Ampuero, Julia Guimarães, Luiz H. Villasboas, Leonardo Rocha, Ana T. Schriefer, Nicolaus Albert Borges Sousa, Rosana Santos Talhari, Anette Chrusciak Penna, Gerson de Oliveira Carvalho Filho, Edgar Marcelino de |
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p. 1-6 |
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2010 |
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2010-12 |
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2013-07-26T17:45:15Z |
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1935-2727 |
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v. 4, n. 12 |
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1935-2727 v. 4, n. 12 |
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