Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice.
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5387 |
Resumo: | The effect of hypothyroidism on the ascitic form of Ehrlich tumor in either non-ovariectomized or ovariectomized adult female mice was studied. Hypothyroidism was induced by treatment with propylthiouracil (PTU). Forty mice were divided into four groups: ovariectomized hypothyroid, non-ovariectomized hypothyroid, ovariectomized euthyroid, and nonovariectomized euthyroid. Mice were inoculated intraperitoneally with a suspension of 29 x 106 cells and tumor growth curve was determined by measuring abdominal circumference for 10 days. At the end of the experimental period, mice were sacrificed. Hypothyroidism resulted in lower abdominal circumference and lower volume of ascitic liquid. However, hypothyroidism did not affect the viability or concentration of tumor cells, the nucleus- cytoplasm ratio, or the mean nuclear diameter of neoplastic cells.The number of nucleolar organizer regions (NOR) of neoplastic cells did not differ among groups. In conclusion, hypothyroidism, regardless of the functional state of the gonads, resulted in a delayed growth of the ascitic form of Ehrlich tumor as it reduced the liquid volume and did not reduce the number, viability, or diameter of neoplastic cells. |
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Silva, Alessandra E.Ferreira, EnioOcarino, Natália de MeloMoraes, Jader R. C.Cassali, Geovanni DantasSerakides, RogériaSilva, Alessandra E.Ferreira, EnioOcarino, Natália de MeloMoraes, Jader R. C.Cassali, Geovanni DantasSerakides, Rogéria2012-02-10T18:42:29Z2012-02-10T18:42:29Z200709712119http://www.repositorio.ufba.br/ri/handle/ri/5387v. 7, n. 2The effect of hypothyroidism on the ascitic form of Ehrlich tumor in either non-ovariectomized or ovariectomized adult female mice was studied. Hypothyroidism was induced by treatment with propylthiouracil (PTU). Forty mice were divided into four groups: ovariectomized hypothyroid, non-ovariectomized hypothyroid, ovariectomized euthyroid, and nonovariectomized euthyroid. Mice were inoculated intraperitoneally with a suspension of 29 x 106 cells and tumor growth curve was determined by measuring abdominal circumference for 10 days. At the end of the experimental period, mice were sacrificed. Hypothyroidism resulted in lower abdominal circumference and lower volume of ascitic liquid. However, hypothyroidism did not affect the viability or concentration of tumor cells, the nucleus- cytoplasm ratio, or the mean nuclear diameter of neoplastic cells.The number of nucleolar organizer regions (NOR) of neoplastic cells did not differ among groups. In conclusion, hypothyroidism, regardless of the functional state of the gonads, resulted in a delayed growth of the ascitic form of Ehrlich tumor as it reduced the liquid volume and did not reduce the number, viability, or diameter of neoplastic cells.Submitted by Alessandra Estrela-Lima (aestrela@ufba.br) on 2012-02-10T18:42:28Z No. of bitstreams: 1 The Journal of Applied Research Hipotireoidismo.pdf: 202270 bytes, checksum: 002306350e6a1df626da0b215ed9e079 (MD5)Made available in DSpace on 2012-02-10T18:42:29Z (GMT). No. of bitstreams: 1 The Journal of Applied Research Hipotireoidismo.pdf: 202270 bytes, checksum: 002306350e6a1df626da0b215ed9e079 (MD5) Previous issue date: 2007http://jrnlappliedresearch.com/articles/Vol7Iss2/01SerakidesVol7No2.pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAmiceEhrlich tumorhypothyroidismovariectomyEffect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice.The Journal of Applied Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALThe Journal of Applied Research Hipotireoidismo.pdfThe Journal of Applied Research Hipotireoidismo.pdfapplication/pdf202270https://repositorio.ufba.br/bitstream/ri/5387/1/The%20Journal%20of%20Applied%20Research%20Hipotireoidismo.pdf002306350e6a1df626da0b215ed9e079MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5387/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTThe Journal of Applied Research Hipotireoidismo.pdf.txtThe Journal of Applied Research Hipotireoidismo.pdf.txtExtracted texttext/plain25564https://repositorio.ufba.br/bitstream/ri/5387/3/The%20Journal%20of%20Applied%20Research%20Hipotireoidismo.pdf.txt9755481bc96ff1d4122c03b9a86e4760MD53ri/53872022-07-05 14:03:33.657oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:33Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice. |
dc.title.alternative.pt_BR.fl_str_mv |
The Journal of Applied Research |
title |
Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice. |
spellingShingle |
Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice. Silva, Alessandra E. mice Ehrlich tumor hypothyroidism ovariectomy |
title_short |
Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice. |
title_full |
Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice. |
title_fullStr |
Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice. |
title_full_unstemmed |
Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice. |
title_sort |
Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice. |
author |
Silva, Alessandra E. |
author_facet |
Silva, Alessandra E. Ferreira, Enio Ocarino, Natália de Melo Moraes, Jader R. C. Cassali, Geovanni Dantas Serakides, Rogéria |
author_role |
author |
author2 |
Ferreira, Enio Ocarino, Natália de Melo Moraes, Jader R. C. Cassali, Geovanni Dantas Serakides, Rogéria |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Alessandra E. Ferreira, Enio Ocarino, Natália de Melo Moraes, Jader R. C. Cassali, Geovanni Dantas Serakides, Rogéria Silva, Alessandra E. Ferreira, Enio Ocarino, Natália de Melo Moraes, Jader R. C. Cassali, Geovanni Dantas Serakides, Rogéria |
dc.subject.por.fl_str_mv |
mice Ehrlich tumor hypothyroidism ovariectomy |
topic |
mice Ehrlich tumor hypothyroidism ovariectomy |
description |
The effect of hypothyroidism on the ascitic form of Ehrlich tumor in either non-ovariectomized or ovariectomized adult female mice was studied. Hypothyroidism was induced by treatment with propylthiouracil (PTU). Forty mice were divided into four groups: ovariectomized hypothyroid, non-ovariectomized hypothyroid, ovariectomized euthyroid, and nonovariectomized euthyroid. Mice were inoculated intraperitoneally with a suspension of 29 x 106 cells and tumor growth curve was determined by measuring abdominal circumference for 10 days. At the end of the experimental period, mice were sacrificed. Hypothyroidism resulted in lower abdominal circumference and lower volume of ascitic liquid. However, hypothyroidism did not affect the viability or concentration of tumor cells, the nucleus- cytoplasm ratio, or the mean nuclear diameter of neoplastic cells.The number of nucleolar organizer regions (NOR) of neoplastic cells did not differ among groups. In conclusion, hypothyroidism, regardless of the functional state of the gonads, resulted in a delayed growth of the ascitic form of Ehrlich tumor as it reduced the liquid volume and did not reduce the number, viability, or diameter of neoplastic cells. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2012-02-10T18:42:29Z |
dc.date.available.fl_str_mv |
2012-02-10T18:42:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/5387 |
dc.identifier.issn.none.fl_str_mv |
09712119 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 7, n. 2 |
identifier_str_mv |
09712119 v. 7, n. 2 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/5387 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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http://jrnlappliedresearch.com/articles/Vol7Iss2/01SerakidesVol7No2.pdf |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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UFBA |
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UFBA |
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Repositório Institucional da UFBA |
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