Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice.

Detalhes bibliográficos
Autor(a) principal: Silva, Alessandra E.
Data de Publicação: 2007
Outros Autores: Ferreira, Enio, Ocarino, Natália de Melo, Moraes, Jader R. C., Cassali, Geovanni Dantas, Serakides, Rogéria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5387
Resumo: The effect of hypothyroidism on the ascitic form of Ehrlich tumor in either non-ovariectomized or ovariectomized adult female mice was studied. Hypothyroidism was induced by treatment with propylthiouracil (PTU). Forty mice were divided into four groups: ovariectomized hypothyroid, non-ovariectomized hypothyroid, ovariectomized euthyroid, and nonovariectomized euthyroid. Mice were inoculated intraperitoneally with a suspension of 29 x 106 cells and tumor growth curve was determined by measuring abdominal circumference for 10 days. At the end of the experimental period, mice were sacrificed. Hypothyroidism resulted in lower abdominal circumference and lower volume of ascitic liquid. However, hypothyroidism did not affect the viability or concentration of tumor cells, the nucleus- cytoplasm ratio, or the mean nuclear diameter of neoplastic cells.The number of nucleolar organizer regions (NOR) of neoplastic cells did not differ among groups. In conclusion, hypothyroidism, regardless of the functional state of the gonads, resulted in a delayed growth of the ascitic form of Ehrlich tumor as it reduced the liquid volume and did not reduce the number, viability, or diameter of neoplastic cells.
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spelling Silva, Alessandra E.Ferreira, EnioOcarino, Natália de MeloMoraes, Jader R. C.Cassali, Geovanni DantasSerakides, RogériaSilva, Alessandra E.Ferreira, EnioOcarino, Natália de MeloMoraes, Jader R. C.Cassali, Geovanni DantasSerakides, Rogéria2012-02-10T18:42:29Z2012-02-10T18:42:29Z200709712119http://www.repositorio.ufba.br/ri/handle/ri/5387v. 7, n. 2The effect of hypothyroidism on the ascitic form of Ehrlich tumor in either non-ovariectomized or ovariectomized adult female mice was studied. Hypothyroidism was induced by treatment with propylthiouracil (PTU). Forty mice were divided into four groups: ovariectomized hypothyroid, non-ovariectomized hypothyroid, ovariectomized euthyroid, and nonovariectomized euthyroid. Mice were inoculated intraperitoneally with a suspension of 29 x 106 cells and tumor growth curve was determined by measuring abdominal circumference for 10 days. At the end of the experimental period, mice were sacrificed. Hypothyroidism resulted in lower abdominal circumference and lower volume of ascitic liquid. However, hypothyroidism did not affect the viability or concentration of tumor cells, the nucleus- cytoplasm ratio, or the mean nuclear diameter of neoplastic cells.The number of nucleolar organizer regions (NOR) of neoplastic cells did not differ among groups. In conclusion, hypothyroidism, regardless of the functional state of the gonads, resulted in a delayed growth of the ascitic form of Ehrlich tumor as it reduced the liquid volume and did not reduce the number, viability, or diameter of neoplastic cells.Submitted by Alessandra Estrela-Lima (aestrela@ufba.br) on 2012-02-10T18:42:28Z No. of bitstreams: 1 The Journal of Applied Research Hipotireoidismo.pdf: 202270 bytes, checksum: 002306350e6a1df626da0b215ed9e079 (MD5)Made available in DSpace on 2012-02-10T18:42:29Z (GMT). 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dc.title.pt_BR.fl_str_mv Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice.
dc.title.alternative.pt_BR.fl_str_mv The Journal of Applied Research
title Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice.
spellingShingle Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice.
Silva, Alessandra E.
mice
Ehrlich tumor
hypothyroidism
ovariectomy
title_short Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice.
title_full Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice.
title_fullStr Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice.
title_full_unstemmed Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice.
title_sort Effect of Hypothyroidism on Growth, Viability, and Characteristics of Ascitic Ehrlich Tumor Cells in Ovariectomized and Non-ovariectomized Mice.
author Silva, Alessandra E.
author_facet Silva, Alessandra E.
Ferreira, Enio
Ocarino, Natália de Melo
Moraes, Jader R. C.
Cassali, Geovanni Dantas
Serakides, Rogéria
author_role author
author2 Ferreira, Enio
Ocarino, Natália de Melo
Moraes, Jader R. C.
Cassali, Geovanni Dantas
Serakides, Rogéria
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Alessandra E.
Ferreira, Enio
Ocarino, Natália de Melo
Moraes, Jader R. C.
Cassali, Geovanni Dantas
Serakides, Rogéria
Silva, Alessandra E.
Ferreira, Enio
Ocarino, Natália de Melo
Moraes, Jader R. C.
Cassali, Geovanni Dantas
Serakides, Rogéria
dc.subject.por.fl_str_mv mice
Ehrlich tumor
hypothyroidism
ovariectomy
topic mice
Ehrlich tumor
hypothyroidism
ovariectomy
description The effect of hypothyroidism on the ascitic form of Ehrlich tumor in either non-ovariectomized or ovariectomized adult female mice was studied. Hypothyroidism was induced by treatment with propylthiouracil (PTU). Forty mice were divided into four groups: ovariectomized hypothyroid, non-ovariectomized hypothyroid, ovariectomized euthyroid, and nonovariectomized euthyroid. Mice were inoculated intraperitoneally with a suspension of 29 x 106 cells and tumor growth curve was determined by measuring abdominal circumference for 10 days. At the end of the experimental period, mice were sacrificed. Hypothyroidism resulted in lower abdominal circumference and lower volume of ascitic liquid. However, hypothyroidism did not affect the viability or concentration of tumor cells, the nucleus- cytoplasm ratio, or the mean nuclear diameter of neoplastic cells.The number of nucleolar organizer regions (NOR) of neoplastic cells did not differ among groups. In conclusion, hypothyroidism, regardless of the functional state of the gonads, resulted in a delayed growth of the ascitic form of Ehrlich tumor as it reduced the liquid volume and did not reduce the number, viability, or diameter of neoplastic cells.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2012-02-10T18:42:29Z
dc.date.available.fl_str_mv 2012-02-10T18:42:29Z
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dc.identifier.issn.none.fl_str_mv 09712119
dc.identifier.number.pt_BR.fl_str_mv v. 7, n. 2
identifier_str_mv 09712119
v. 7, n. 2
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