BCG Revaccination does not protect against leprosy in the Brazilian Amazon: a Cluster Randomised Trial
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/2080 |
Resumo: | p.167 |
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Cunha, Sérgio Souza daAlexander, NealBarreto, Mauricio LimaPereira, Emilia S.Dourado, Maria Inês CostaMaroja, Maria de FátimaIchihara, YuryBrito, Silvana Castro dePereira, SusanRodrigues, Laura CunhaCunha, Sérgio Souza daAlexander, NealBarreto, Mauricio LimaPereira, Emilia S.Dourado, Maria Inês CostaMaroja, Maria de FátimaIchihara, YuryBrito, Silvana Castro dePereira, SusanRodrigues, Laura Cunha2011-08-07T12:08:27Z2011-08-07T12:08:27Z20081935-2735http://www.repositorio.ufba.br/ri/handle/ri/20802(2):e167p.167Background Although BCG has been found to impart protection against leprosy in many populations, the utility of repeat or booster BCG vaccinations is still unclear. When a policy of giving a second BCG dose to school children in Brazil was introduced, a trial was conducted to assess its impact against tuberculosis, and a leprosy component was then undertaken in parallel. Objective: to estimate the protection against leprosy imparted by a second dose of BCG given to schoolchildren. Methods and Findings This is a cluster randomised community trial, with 6 years and 8 months of follow-up. Study site: City of Manaus, Amazon region, a leprosy-endemic area in Brazil. Participants: 99,770 school children with neonatal BCG (aged 7–14 years at baseline), of whom 42,662 were in the intervention arm (revaccination). Intervention: BCG given by intradermal injection. Main outcome: Leprosy (all clinical forms). Results: The incidence rate ratio of leprosy in the intervention over the control arm within the follow-up, in schoolchildren with neonatal BCG, controlled for potential confounders and adjusted for clustering, was 0.99 (95% confidence interval: 0.68 to 1.45). Conclusions/Significance There was no evidence of protection conferred by the second dose of BCG vaccination in school children against leprosy during the trial follow-up. These results point to a need to consider the effectiveness of the current policy of BCG vaccination of contacts of leprosy cases in Brazilian Amazon region.Submitted by Rigaud Andréa (andrearigaud16@yahoo.com.br) on 2011-08-07T12:08:27Z No. of bitstreams: 1 per%20int2008.13[1].pdf: 411174 bytes, checksum: 597c609f5a92a93548579b7fe59d8a0b (MD5)Made available in DSpace on 2011-08-07T12:08:27Z (GMT). No. of bitstreams: 1 per%20int2008.13[1].pdf: 411174 bytes, checksum: 597c609f5a92a93548579b7fe59d8a0b (MD5) Previous issue date: 2008-02-13BCG Revaccination does not protect against leprosy in the Brazilian Amazon: a Cluster Randomised TrialPLoS Neglected Tropical Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALper%20int2008.13[1].pdfper%20int2008.13[1].pdfapplication/pdf411174https://repositorio.ufba.br/bitstream/ri/2080/1/per%2520int2008.13%5b1%5d.pdf597c609f5a92a93548579b7fe59d8a0bMD51LICENSElicense.txtlicense.txttext/plain1906https://repositorio.ufba.br/bitstream/ri/2080/2/license.txte511eb01d63c53c630476f1b0077808dMD52TEXTper%20int2008.13[1].pdf.txtper%20int2008.13[1].pdf.txtExtracted texttext/plain47673https://repositorio.ufba.br/bitstream/ri/2080/3/per%2520int2008.13%5b1%5d.pdf.txt64e87d2ed2598e3fed47bbffa0f7f5caMD53ri/20802022-10-11 11:53:33.406oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-10-11T14:53:33Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
BCG Revaccination does not protect against leprosy in the Brazilian Amazon: a Cluster Randomised Trial |
| dc.title.alternative.pt_BR.fl_str_mv |
PLoS Neglected Tropical Diseases |
| title |
BCG Revaccination does not protect against leprosy in the Brazilian Amazon: a Cluster Randomised Trial |
| spellingShingle |
BCG Revaccination does not protect against leprosy in the Brazilian Amazon: a Cluster Randomised Trial Cunha, Sérgio Souza da |
| title_short |
BCG Revaccination does not protect against leprosy in the Brazilian Amazon: a Cluster Randomised Trial |
| title_full |
BCG Revaccination does not protect against leprosy in the Brazilian Amazon: a Cluster Randomised Trial |
| title_fullStr |
BCG Revaccination does not protect against leprosy in the Brazilian Amazon: a Cluster Randomised Trial |
| title_full_unstemmed |
BCG Revaccination does not protect against leprosy in the Brazilian Amazon: a Cluster Randomised Trial |
| title_sort |
BCG Revaccination does not protect against leprosy in the Brazilian Amazon: a Cluster Randomised Trial |
| author |
Cunha, Sérgio Souza da |
| author_facet |
Cunha, Sérgio Souza da Alexander, Neal Barreto, Mauricio Lima Pereira, Emilia S. Dourado, Maria Inês Costa Maroja, Maria de Fátima Ichihara, Yury Brito, Silvana Castro de Pereira, Susan Rodrigues, Laura Cunha |
| author_role |
author |
| author2 |
Alexander, Neal Barreto, Mauricio Lima Pereira, Emilia S. Dourado, Maria Inês Costa Maroja, Maria de Fátima Ichihara, Yury Brito, Silvana Castro de Pereira, Susan Rodrigues, Laura Cunha |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cunha, Sérgio Souza da Alexander, Neal Barreto, Mauricio Lima Pereira, Emilia S. Dourado, Maria Inês Costa Maroja, Maria de Fátima Ichihara, Yury Brito, Silvana Castro de Pereira, Susan Rodrigues, Laura Cunha Cunha, Sérgio Souza da Alexander, Neal Barreto, Mauricio Lima Pereira, Emilia S. Dourado, Maria Inês Costa Maroja, Maria de Fátima Ichihara, Yury Brito, Silvana Castro de Pereira, Susan Rodrigues, Laura Cunha |
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p.167 |
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2008 |
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2008 |
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2011-08-07T12:08:27Z |
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