Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis

Detalhes bibliográficos
Autor(a) principal: Nascimento, A. L. T. O.
Data de Publicação: 2004
Outros Autores: Ko, A. I., Martins, E. A. L., Monteiro-Vitorello, C. B., Haake, D. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7531
Resumo: Texto completo:acesso restrito. p. 2164-2172
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spelling Nascimento, A. L. T. O.Ko, A. I.Martins, E. A. L.Monteiro-Vitorello, C. B.Haake, D. A.Nascimento, A. L. T. O.Ko, A. I.Martins, E. A. L.Monteiro-Vitorello, C. B.Haake, D. A.2012-12-14T12:51:21Z20040021-9193http://www.repositorio.ufba.br/ri/handle/ri/7531v. 186, n. 7Texto completo:acesso restrito. p. 2164-2172Leptospira species colonize a significant proportion of rodent populations worldwide and produce life-threatening infections in accidental hosts, including humans. Complete genome sequencing of Leptospira interrogans serovar Copenhageni and comparative analysis with the available Leptospira interrogans serovar Lai genome reveal that despite overall genetic similarity there are significant structural differences, including a large chromosomal inversion and extensive variation in the number and distribution of insertion sequence elements. Genome sequence analysis elucidates many of the novel aspects of leptospiral physiology relating to energy metabolism, oxygen tolerance, two-component signal transduction systems, and mechanisms of pathogenesis. A broad array of transcriptional regulation proteins and two new families of afimbrial adhesins which contribute to host tissue colonization in the early steps of infection were identified. Differences in genes involved in the biosynthesis of lipopolysaccharide O side chains between the Copenhageni and Lai serovars were identified, offering an important starting point for the elucidation of the organism's complex polysaccharide surface antigens. Differences in adhesins and in lipopolysaccharide might be associated with the adaptation of serovars Copenhageni and Lai to different animal hosts. Hundreds of genes encoding surface-exposed lipoproteins and transmembrane outer membrane proteins were identified as candidates for development of vaccines for the prevention of leptospirosis.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-12-14T12:51:21Z No. of bitstreams: 1 2164.full.pdf: 610782 bytes, checksum: 4b8154199edfbe3c64cb9929eaf4b162 (MD5)Made available in DSpace on 2012-12-14T12:51:21Z (GMT). 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dc.title.pt_BR.fl_str_mv Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
dc.title.alternative.pt_BR.fl_str_mv Journal of Bacteriology
title Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
spellingShingle Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
Nascimento, A. L. T. O.
title_short Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
title_full Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
title_fullStr Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
title_full_unstemmed Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
title_sort Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
author Nascimento, A. L. T. O.
author_facet Nascimento, A. L. T. O.
Ko, A. I.
Martins, E. A. L.
Monteiro-Vitorello, C. B.
Haake, D. A.
author_role author
author2 Ko, A. I.
Martins, E. A. L.
Monteiro-Vitorello, C. B.
Haake, D. A.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Nascimento, A. L. T. O.
Ko, A. I.
Martins, E. A. L.
Monteiro-Vitorello, C. B.
Haake, D. A.
Nascimento, A. L. T. O.
Ko, A. I.
Martins, E. A. L.
Monteiro-Vitorello, C. B.
Haake, D. A.
description Texto completo:acesso restrito. p. 2164-2172
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2012-12-14T12:51:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7531
dc.identifier.issn.none.fl_str_mv 0021-9193
dc.identifier.number.pt_BR.fl_str_mv v. 186, n. 7
identifier_str_mv 0021-9193
v. 186, n. 7
url http://www.repositorio.ufba.br/ri/handle/ri/7531
dc.language.iso.fl_str_mv eng
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