Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10

Detalhes bibliográficos
Autor(a) principal: Lima, Milena da Silva
Data de Publicação: 2013
Outros Autores: Quintans Júnior, Lucindo José, Santana, Wagno Alcântara de, Kaneto, Carla Martins, Soares, Milena Botelho Pereira, Villarreal, Cristiane Flora
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12617
Resumo: Texto completo. Acesso restrito. p. 112–117
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spelling Lima, Milena da SilvaQuintans Júnior, Lucindo JoséSantana, Wagno Alcântara deKaneto, Carla MartinsSoares, Milena Botelho PereiraVillarreal, Cristiane FloraLima, Milena da SilvaQuintans Júnior, Lucindo JoséSantana, Wagno Alcântara deKaneto, Carla MartinsSoares, Milena Botelho PereiraVillarreal, Cristiane Flora2013-08-16T19:12:40Z2013-08-16T19:12:40Z20130014-2999http://www.repositorio.ufba.br/ri/handle/ri/12617v. 699, n. 1–3Texto completo. Acesso restrito. p. 112–117Carvacrol, a phenolic monoterpene, has been reported to possess anti-inflammatory properties. However, the mechanisms involved in its pharmacological properties are currently not well understood. In the present study, the contribution of cytokine modulation to the anti-inflammatory effects of carvacrol was investigated in a classical inflammation model: the complete Freund’s adjuvant (CFA)-induced paw inflammation in mice. The paw edema was measured using a plesthismometer. Paw tissue was removed 2 h after the inflammatory stimulus to determine the levels of prostaglandin E2 (PGE2) by enzyme immunoassay, the levels of interleukin-1 β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-10 (IL-10) by ELISA or the mRNA expression of cyclooxygenase-2 (COX-2), IL-1β, TNF-α, and IL-10 by real-time PCR. Administration of carvacrol produced anti-inflammatory effects against CFA-induced inflammation in mice. Treatment of mice with carvacrol at 50 and 100 mg/kg attenuated the paw edema and reduced the IL-1β and PGE2, but not TNF-α, local levels. Similarly, carvacrol (100 mg/kg) reduced the COX-2 and IL-1β mRNA expression. The levels of IL-10, an anti-inflammatory cytokine, and the IL-10 mRNA expression in the inflamed paw were enhanced by carvacrol. In addition, the treatment with carvacrol did not reduce the CFA-induced paw edema in IL-10 knockout mice. The present results suggest that carvacrol causes anti-inflammatory effects by reducing the production of inflammatory mediators, such as IL-1β and prostanoids, possibly through the induction of IL-10 release.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-07-08T13:16:49Z No. of bitstreams: 1 55555555555555.pdf: 611395 bytes, checksum: 24cfe10ac84d533e244253fe7d12fa1a (MD5)Approved for entry into archive by Alda Lima da Silva(sivalda@ufba.br) on 2013-08-16T19:12:40Z (GMT) No. of bitstreams: 1 55555555555555.pdf: 611395 bytes, checksum: 24cfe10ac84d533e244253fe7d12fa1a (MD5)Made available in DSpace on 2013-08-16T19:12:40Z (GMT). No. of bitstreams: 1 55555555555555.pdf: 611395 bytes, checksum: 24cfe10ac84d533e244253fe7d12fa1a (MD5) Previous issue date: 2013SalvadorEuropean Journal of Pharmacologyhttp://dx.doi.org/10.1016/j.ejphar.2012.11.040reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACarvacrolAnti-inflammatoryCytokinesInterleukin-10PGE2Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10European Journal of Pharmacologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL55555555555555.pdf55555555555555.pdfapplication/pdf611395https://repositorio.ufba.br/bitstream/ri/12617/1/55555555555555.pdf24cfe10ac84d533e244253fe7d12fa1aMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12617/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT55555555555555.pdf.txt55555555555555.pdf.txtExtracted texttext/plain30413https://repositorio.ufba.br/bitstream/ri/12617/3/55555555555555.pdf.txt195d2a1ad7ba399ec296404cb365eb9fMD53ri/126172022-07-05 14:02:51.256oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10
dc.title.alternative.pt_BR.fl_str_mv European Journal of Pharmacology
title Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10
spellingShingle Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10
Lima, Milena da Silva
Carvacrol
Anti-inflammatory
Cytokines
Interleukin-10
PGE2
title_short Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10
title_full Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10
title_fullStr Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10
title_full_unstemmed Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10
title_sort Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10
author Lima, Milena da Silva
author_facet Lima, Milena da Silva
Quintans Júnior, Lucindo José
Santana, Wagno Alcântara de
Kaneto, Carla Martins
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author_role author
author2 Quintans Júnior, Lucindo José
Santana, Wagno Alcântara de
Kaneto, Carla Martins
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Milena da Silva
Quintans Júnior, Lucindo José
Santana, Wagno Alcântara de
Kaneto, Carla Martins
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Lima, Milena da Silva
Quintans Júnior, Lucindo José
Santana, Wagno Alcântara de
Kaneto, Carla Martins
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
dc.subject.por.fl_str_mv Carvacrol
Anti-inflammatory
Cytokines
Interleukin-10
PGE2
topic Carvacrol
Anti-inflammatory
Cytokines
Interleukin-10
PGE2
description Texto completo. Acesso restrito. p. 112–117
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-08-16T19:12:40Z
dc.date.available.fl_str_mv 2013-08-16T19:12:40Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12617
dc.identifier.issn.none.fl_str_mv 0014-2999
dc.identifier.number.pt_BR.fl_str_mv v. 699, n. 1–3
identifier_str_mv 0014-2999
v. 699, n. 1–3
url http://www.repositorio.ufba.br/ri/handle/ri/12617
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv European Journal of Pharmacology
publisher.none.fl_str_mv European Journal of Pharmacology
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.ejphar.2012.11.040
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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