Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5881 |
Resumo: | Acesso restrito: Texto completo. p. 215-220. |
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Oliveria, Diêgo Madureira deBarreto, George Emílio SampaioAndrade, Deyse Valverde Gomes deSaraceno, EzequielAon Bertolino, LauraCapani, FranciscoEl-Bachá, Ramon dos SantosGiraldez, Lisandro DiegoOliveria, Diêgo Madureira deBarreto, George Emílio SampaioAndrade, Deyse Valverde Gomes deSaraceno, EzequielAon Bertolino, LauraCapani, FranciscoEl-Bachá, Ramon dos SantosGiraldez, Lisandro Diego2012-05-16T17:18:47Z20090364-3190http://www.repositorio.ufba.br/ri/handle/ri/5881v. 34, n. 2Acesso restrito: Texto completo. p. 215-220.Parkinson0s disease (PD) is one of the most important neurodegenerative worldwide disorders. The potential cytoprotective effects of aqueous extract of Valeriana officinalis on rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells were demonstrated. The cytotoxicity, cell viability and analysis of cellular morphology were performed by MTT-tetrazole (3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and phase contrast microscopy, respectively. Significant changes in the cellular morphology, and condensation of the cell body could be observed when cells were treated with 300 nM rotenone for 48 h. Three different concentrations of Valeriana officinalis extract were used (0.049, 0.098 and 0.195 mg/mL). These extracts brought about an increase of 7.0 ± 1.3%, 14.5 ± 1.3% and 14.5 ± 3.2% in cell viability. Our results indicated that neuroprotector action of the Valeriana officinalis extract provides support for later studies as they help understanding this drug for the development of cytoprotective various therapies in PD.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-16T17:18:46Z No. of bitstreams: 1 __www.springerlink.com_c...467711443172238n_fulltext.pdf: 121998 bytes, checksum: 10a2f858f8e32cf24d3b8604bce32d47 (MD5)Made available in DSpace on 2012-05-16T17:18:47Z (GMT). No. of bitstreams: 1 __www.springerlink.com_c...467711443172238n_fulltext.pdf: 121998 bytes, checksum: 10a2f858f8e32cf24d3b8604bce32d47 (MD5) Previous issue date: 2009http://www.springerlink.com/content/467711443172238n/fulltext.pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAParkinson DiseaseSH-SY5Y cellsValeriana officinalisCytoprotectiveRotenoneCytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson DiseaseNeurochemical Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL__www.springerlink.com_c...467711443172238n_fulltext.pdf__www.springerlink.com_c...467711443172238n_fulltext.pdfapplication/pdf121998https://repositorio.ufba.br/bitstream/ri/5881/1/__www.springerlink.com_c...467711443172238n_fulltext.pdf10a2f858f8e32cf24d3b8604bce32d47MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5881/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT__www.springerlink.com_c...467711443172238n_fulltext.pdf.txt__www.springerlink.com_c...467711443172238n_fulltext.pdf.txtExtracted texttext/plain29491https://repositorio.ufba.br/bitstream/ri/5881/3/__www.springerlink.com_c...467711443172238n_fulltext.pdf.txt27cb331c504fc26315811f85f7a188fdMD53ri/58812022-07-05 14:03:43.833oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:43Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease |
| dc.title.alternative.pt_BR.fl_str_mv |
Neurochemical Research |
| title |
Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease |
| spellingShingle |
Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease Oliveria, Diêgo Madureira de Parkinson Disease SH-SY5Y cells Valeriana officinalis Cytoprotective Rotenone |
| title_short |
Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease |
| title_full |
Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease |
| title_fullStr |
Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease |
| title_full_unstemmed |
Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease |
| title_sort |
Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease |
| author |
Oliveria, Diêgo Madureira de |
| author_facet |
Oliveria, Diêgo Madureira de Barreto, George Emílio Sampaio Andrade, Deyse Valverde Gomes de Saraceno, Ezequiel Aon Bertolino, Laura Capani, Francisco El-Bachá, Ramon dos Santos Giraldez, Lisandro Diego |
| author_role |
author |
| author2 |
Barreto, George Emílio Sampaio Andrade, Deyse Valverde Gomes de Saraceno, Ezequiel Aon Bertolino, Laura Capani, Francisco El-Bachá, Ramon dos Santos Giraldez, Lisandro Diego |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveria, Diêgo Madureira de Barreto, George Emílio Sampaio Andrade, Deyse Valverde Gomes de Saraceno, Ezequiel Aon Bertolino, Laura Capani, Francisco El-Bachá, Ramon dos Santos Giraldez, Lisandro Diego Oliveria, Diêgo Madureira de Barreto, George Emílio Sampaio Andrade, Deyse Valverde Gomes de Saraceno, Ezequiel Aon Bertolino, Laura Capani, Francisco El-Bachá, Ramon dos Santos Giraldez, Lisandro Diego |
| dc.subject.por.fl_str_mv |
Parkinson Disease SH-SY5Y cells Valeriana officinalis Cytoprotective Rotenone |
| topic |
Parkinson Disease SH-SY5Y cells Valeriana officinalis Cytoprotective Rotenone |
| description |
Acesso restrito: Texto completo. p. 215-220. |
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2009 |
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2009 |
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2012-05-16T17:18:47Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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0364-3190 |
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v. 34, n. 2 |
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0364-3190 v. 34, n. 2 |
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http://www.repositorio.ufba.br/ri/handle/ri/5881 |
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