Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutans

Detalhes bibliográficos
Autor(a) principal: Almeida, Luciana Salles Branco de
Data de Publicação: 2008
Outros Autores: Murata, Ramiro Mendonça, Yatsuda, Regiane, Santos, M. H. dos, Nagem, T. J., Alencar, S. M., Koo, H., Rosalen, P. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13636
Resumo: Texto completo: acesso restrito. p. 886-891
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spelling Almeida, Luciana Salles Branco deMurata, Ramiro MendonçaYatsuda, RegianeSantos, M. H. dosNagem, T. J.Alencar, S. M.Koo, H.Rosalen, P. L.Almeida, Luciana Salles Branco deMurata, Ramiro MendonçaYatsuda, RegianeSantos, M. H. dosNagem, T. J.Alencar, S. M.Koo, H.Rosalen, P. L.2013-11-13T17:38:59Z20080944-7113http://repositorio.ufba.br/ri/handle/ri/13636v. 15, n. 10Texto completo: acesso restrito. p. 886-891This in vitro study evaluated the antimicrobial activity of extracts obtained from Rheedia brasiliensis fruit (bacupari) and its bioactive compound against Streptococcus mutans. Hexane, ethyl-acetate and ethanolic extracts obtained (concentrations ranging from 6.25 to 800 μg/ml) were tested against S. mutans UA159 through MIC/MBC assays. S. mutans 5-days-old biofilms were treated with the active extracts (100×MIC) for 0, 1, 2, 3 and 4 h (time-kill) and plated for colony counting (CFU/ml). Active extracts were submitted to exploratory chemical analyses so as to isolate and identify the bioactive compound using spectroscopic methods. The bioactive compound (concentrations ranging from 0.625 to 80 μg/ml) was then tested through MIC/MBC assays. Peel and seed hexane extracts showed antimicrobial activity against planktonic cells at low concentrations and were thus selected for the time kill test. These hexane extracts reduced S. mutans biofilm viability after 4 h, certifying of the bioactive compound presence. The bioactive compound identified was the polyprenylated benzophenone 7-epiclusianone, which showed a good antimicrobial activity at low concentrations (MIC: 1.25–2.5 μg/ml; MBC: 10–20 μg/ml). The results indicated that 7-epiclusianone may be used as a new agent to control S. mutans biofilms; however, more studies are needed to further elucidate the mechanisms of action and the anticariogenic potential of such compound found in R. brasiliensis.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-11-08T12:39:29Z No. of bitstreams: 1 1-s2.0-S0944711307003169-main.pdf: 213007 bytes, checksum: 6c74a33804f84529c216ae3c59ef28d2 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-13T17:38:59Z (GMT) No. of bitstreams: 1 1-s2.0-S0944711307003169-main.pdf: 213007 bytes, checksum: 6c74a33804f84529c216ae3c59ef28d2 (MD5)Made available in DSpace on 2013-11-13T17:38:59Z (GMT). No. of bitstreams: 1 1-s2.0-S0944711307003169-main.pdf: 213007 bytes, checksum: 6c74a33804f84529c216ae3c59ef28d2 (MD5) Previous issue date: 2009http://dx.doi.org/10.1016/j.phymed.2007.12.003reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBARheedia brasiliensisAntimicrobial activity7-EpiclusianoneStreptococcus mutansAntimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutansPhytomedicineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S0944711307003169-main.pdf1-s2.0-S0944711307003169-main.pdfapplication/pdf213007https://repositorio.ufba.br/bitstream/ri/13636/1/1-s2.0-S0944711307003169-main.pdf6c74a33804f84529c216ae3c59ef28d2MD51LICENSElicense.txtlicense.txttext/plain1383https://repositorio.ufba.br/bitstream/ri/13636/2/license.txt05eca2f01d0b3307819d0369dab18a34MD52TEXT1-s2.0-S0944711307003169-main.pdf.txt1-s2.0-S0944711307003169-main.pdf.txtExtracted texttext/plain26048https://repositorio.ufba.br/bitstream/ri/13636/3/1-s2.0-S0944711307003169-main.pdf.txt82d0054f91bcbfcfd3e7b26d1d6003e0MD53ri/136362022-09-15 11:35:18.587oai:repositorio.ufba.br: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ório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-09-15T14:35:18Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutans
dc.title.alternative.pt_BR.fl_str_mv Phytomedicine
title Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutans
spellingShingle Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutans
Almeida, Luciana Salles Branco de
Rheedia brasiliensis
Antimicrobial activity
7-Epiclusianone
Streptococcus mutans
title_short Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutans
title_full Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutans
title_fullStr Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutans
title_full_unstemmed Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutans
title_sort Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutans
author Almeida, Luciana Salles Branco de
author_facet Almeida, Luciana Salles Branco de
Murata, Ramiro Mendonça
Yatsuda, Regiane
Santos, M. H. dos
Nagem, T. J.
Alencar, S. M.
Koo, H.
Rosalen, P. L.
author_role author
author2 Murata, Ramiro Mendonça
Yatsuda, Regiane
Santos, M. H. dos
Nagem, T. J.
Alencar, S. M.
Koo, H.
Rosalen, P. L.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Luciana Salles Branco de
Murata, Ramiro Mendonça
Yatsuda, Regiane
Santos, M. H. dos
Nagem, T. J.
Alencar, S. M.
Koo, H.
Rosalen, P. L.
Almeida, Luciana Salles Branco de
Murata, Ramiro Mendonça
Yatsuda, Regiane
Santos, M. H. dos
Nagem, T. J.
Alencar, S. M.
Koo, H.
Rosalen, P. L.
dc.subject.por.fl_str_mv Rheedia brasiliensis
Antimicrobial activity
7-Epiclusianone
Streptococcus mutans
topic Rheedia brasiliensis
Antimicrobial activity
7-Epiclusianone
Streptococcus mutans
description Texto completo: acesso restrito. p. 886-891
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-11-13T17:38:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13636
dc.identifier.issn.none.fl_str_mv 0944-7113
dc.identifier.number.pt_BR.fl_str_mv v. 15, n. 10
identifier_str_mv 0944-7113
v. 15, n. 10
url http://repositorio.ufba.br/ri/handle/ri/13636
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.phymed.2007.12.003
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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