Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies

Detalhes bibliográficos
Autor(a) principal: Maia Junior, Hugo
Data de Publicação: 2008
Outros Autores: Casoy, Julio, Pimentel, Kleber Santos, Correia, Tania, Athayde, Célia Maria Soares, Cruz, Thomaz Rodrigues Porto da, Coutinho, Elsimar Metzker
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5949
Resumo: Acesso restrito: Texto completo. p. 479-485
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spelling Maia Junior, HugoCasoy, JulioPimentel, Kleber SantosCorreia, TaniaAthayde, Célia Maria SoaresCruz, Thomaz Rodrigues Porto daCoutinho, Elsimar MetzkerMaia Junior, HugoCasoy, JulioPimentel, Kleber SantosCorreia, TaniaAthayde, Célia Maria SoaresCruz, Thomaz Rodrigues Porto daCoutinho, Elsimar Metzker2012-05-24T13:29:01Z20080010-7824http://www.repositorio.ufba.br/ri/handle/ri/5949v. 78, n. 6Acesso restrito: Texto completo. p. 479-485Background: The study was conducted to evaluate vascular endothelial growth factor (VEGF), Cox-2 and aromatase expression in the endometrium of uteri with myomas and other associated pathologies. Study Design: Hysteroscopy was performed in 118 women of reproductive age with myomas and menorrhagia, 40 of whom were using a pill containing 75 mcg gestodene+30 mcg ethinylestradiol. Aromatase p450, VEGF and Cox-2 expression was detected using immunohistochemistry. Fisher's Exact Test and the Mann–Whitney test were used in the statistical analysis, with significance established at pb.05. Results: In patients with myomas and menorrhagia, associated pathologies such as adenomyosis, endometrial polyps and endometriosis were found in 32%, 12% and 17% of cases, respectively. Aromatase, Cox-2 and VEGF expression was greater during the proliferative phase compared to the luteal phase of the cycle or following oral contraceptive use. Conclusion: Endogenous progesterone or combined oral contraceptives are potent inhibitors of VEGF, aromatase and Cox-2 expression in the endometrium of patients with myomas and menorrhagia. © 2008 Elsevier Inc. All rights reserved.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-24T13:29:01Z No. of bitstreams: 1 __ac.els-cdn.com_S001078...0301810acfa88fb02630e508e51d6.pdf: 290239 bytes, checksum: 47cc3c99851aaf11e3e085fc9f1b7884 (MD5)Made available in DSpace on 2012-05-24T13:29:01Z (GMT). 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dc.title.pt_BR.fl_str_mv Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies
dc.title.alternative.pt_BR.fl_str_mv Contraception
title Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies
spellingShingle Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies
Maia Junior, Hugo
Gestodene
VEGF
Aromatase
Cox-2
Myoma
Menorrhagia
title_short Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies
title_full Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies
title_fullStr Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies
title_full_unstemmed Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies
title_sort Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies
author Maia Junior, Hugo
author_facet Maia Junior, Hugo
Casoy, Julio
Pimentel, Kleber Santos
Correia, Tania
Athayde, Célia Maria Soares
Cruz, Thomaz Rodrigues Porto da
Coutinho, Elsimar Metzker
author_role author
author2 Casoy, Julio
Pimentel, Kleber Santos
Correia, Tania
Athayde, Célia Maria Soares
Cruz, Thomaz Rodrigues Porto da
Coutinho, Elsimar Metzker
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Maia Junior, Hugo
Casoy, Julio
Pimentel, Kleber Santos
Correia, Tania
Athayde, Célia Maria Soares
Cruz, Thomaz Rodrigues Porto da
Coutinho, Elsimar Metzker
Maia Junior, Hugo
Casoy, Julio
Pimentel, Kleber Santos
Correia, Tania
Athayde, Célia Maria Soares
Cruz, Thomaz Rodrigues Porto da
Coutinho, Elsimar Metzker
dc.subject.por.fl_str_mv Gestodene
VEGF
Aromatase
Cox-2
Myoma
Menorrhagia
topic Gestodene
VEGF
Aromatase
Cox-2
Myoma
Menorrhagia
description Acesso restrito: Texto completo. p. 479-485
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-05-24T13:29:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5949
dc.identifier.issn.none.fl_str_mv 0010-7824
dc.identifier.number.pt_BR.fl_str_mv v. 78, n. 6
identifier_str_mv 0010-7824
v. 78, n. 6
url http://www.repositorio.ufba.br/ri/handle/ri/5949
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.contraception.2008.07.002
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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reponame_str Repositório Institucional da UFBA
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