Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/17215 |
Resumo: | Texto completo: acesso restrito. p.169–178 |
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Viana, Gustavo Freitas de SousaCarvalho, Chrissie Ferreira deNunes, Lorena S.Rodrigues, Juliana L. G.Ribeiro, Nathália S.Almeida, Diego A. deFerreira, Junia R. DutraAbreu, José Neander SilvaMenezes Filho, José Antônio2015-03-20T16:25:42Z20140378-4274http://repositorio.ufba.br/ri/handle/ri/17215v. 231, n. 2Texto completo: acesso restrito. p.169–178Manganese (Mn), an essential element to humans, in excess can cause neurotoxic damage. So far, Mn exposure assessment has no ideal biomarker. This study aims to investigate the association between Mn exposure, using noninvasive biomarkers, and neuropsychological effects in environmentally exposed adults. The residents of two communities near to a ferromanganese refinery in Bahia, Brazil were evaluated. Volunteers aged 15–55 of both sexes provided scalp hair, axillary hair, fingernail and saliva specimens for Mn determination by electrothermal absorption spectrometry. Several neuropsychological tests were used to evaluate cognitive, attention, memory, motor and executive functions. Significant correlations were observed between Mn in hair (MnH, median 8.95 μg/g), axillary hair (MnAxH,18.49 μg/g) and fingernail (MnFN, 6.91 μg/g) with the performances in several neuropsychological tests. No association was observed between manganese levels in saliva (MnSal, 4.2 μg/L) and any neuropsychological function. Multiple regression analysis detected an inverse association between Log MnH and IQ (β = –4.76 [CI 95% –9.17 to –0.36]) and between Log MnFN and visual working memory (β = –3.33 [CI 95% –6.15 to –0.52]). Direct association was observed between Log MnFN and time of completion in the cognitive flexibility task (β = 56.29 [CI 95% 2.41–110.18]). The Mn biomonitoring using noninvasive biomarkers was able to detect high exposure levels, which were associated with detrimental neuropsychological effects in adults exposed to industrial emissions.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2015-03-18T15:57:33Z No. of bitstreams: 1 Gustavo F. de Sousa Viana.pdf: 807324 bytes, checksum: cafa2beac895da6317c03520c107228d (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2015-03-20T16:25:42Z (GMT) No. of bitstreams: 1 Gustavo F. de Sousa Viana.pdf: 807324 bytes, checksum: cafa2beac895da6317c03520c107228d (MD5)Made available in DSpace on 2015-03-20T16:25:42Z (GMT). No. of bitstreams: 1 Gustavo F. de Sousa Viana.pdf: 807324 bytes, checksum: cafa2beac895da6317c03520c107228d (MD5) Previous issue date: 2014http://dx.doi.org/10.1016/j.toxlet.2014.06.018reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAManganeseBiomarkersNeuropsychological effectsEnvironmental exposureHairFingernailNoninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in BrazilToxicology Lettersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALGustavo F. de Sousa Viana.pdfGustavo F. de Sousa Viana.pdfapplication/pdf807324https://repositorio.ufba.br/bitstream/ri/17215/1/Gustavo%20F.%20de%20Sousa%20Viana.pdfcafa2beac895da6317c03520c107228dMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/17215/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTGustavo F. de Sousa Viana.pdf.txtGustavo F. de Sousa Viana.pdf.txtExtracted texttext/plain58937https://repositorio.ufba.br/bitstream/ri/17215/3/Gustavo%20F.%20de%20Sousa%20Viana.pdf.txta5bda1df92a3e40bb9765263629e407aMD53ri/172152022-07-01 10:46:55.94oai:repositorio.ufba.br:ri/17215VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBLgoKIFBlbG8gcHJvY2Vzc28gZGUgc3VibWlzc++/vW8gZGUgZG9jdW1lbnRvcywgbyBhdXRvciBvdSBzZXUgcmVwcmVzZW50YW50ZSBsZWdhbCwgYW8gYWNlaXRhciAKZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEsIGNvbmNlZGUgYW8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVuaXZlcnNpZGFkZSBGZWRlcmFsIGRhIEJhaGlhIApvIGRpcmVpdG8gZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCBkZSBwcmVzZXJ2Ye+/ve+/vW8uIApFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIGF1dG9yL2NvcHlyaWdodCwgbWFzIGVudGVuZGUgbyBkb2N1bWVudG8gCmNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4KCiBQYXJhIG9zIGRvY3VtZW50b3MgcHVibGljYWRvcyBjb20gcmVwYXNzZSBkZSBkaXJlaXRvcyBkZSBkaXN0cmlidWnvv73vv71vLCBlc3NlIHRlcm1vIGRlIGxpY2Vu77+9YSAKZW50ZW5kZSBxdWU6CgogTWFudGVuZG8gb3MgZGlyZWl0b3MgYXV0b3JhaXMsIHJlcGFzc2Fkb3MgYSB0ZXJjZWlyb3MsIGVtIGNhc28gZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8KcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIGludGVncmFsLCBtYXMgbGliZXJhIGFzIGluZm9ybWHvv73vv71lcyBzb2JyZSBvIGRvY3VtZW50bwooTWV0YWRhZG9zIGVzY3JpdGl2b3MpLgoKIERlc3RhIGZvcm1hLCBhdGVuZGVuZG8gYW9zIGFuc2Vpb3MgZGVzc2EgdW5pdmVyc2lkYWRlIGVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gCmFzIHJlc3Ryae+/ve+/vWVzIGltcG9zdGFzIHBlbG9zIGVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4KCiBQYXJhIGFzIHB1YmxpY2Hvv73vv71lcyBzZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgQWNlc3NvIEFiZXJ0bywgb3MgZGVw77+9c2l0b3MgCmNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gb3MgZGlyZWl0b3MgYXV0b3JhaXMsIG1hcyBtYW5077+9bSBhY2Vzc28gaXJyZXN0cml0byAKYW8gbWV0YWRhZG9zIGUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIGNvbnNlbnRpbWVudG8KIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgZXN0YXJlbSBlbSBpbmljaWF0aXZhcyBkZSBhY2Vzc28gYWJlcnRvLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-01T13:46:55Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil |
dc.title.alternative.pt_BR.fl_str_mv |
Toxicology Letters |
title |
Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil |
spellingShingle |
Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil Viana, Gustavo Freitas de Sousa Manganese Biomarkers Neuropsychological effects Environmental exposure Hair Fingernail |
title_short |
Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil |
title_full |
Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil |
title_fullStr |
Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil |
title_full_unstemmed |
Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil |
title_sort |
Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil |
author |
Viana, Gustavo Freitas de Sousa |
author_facet |
Viana, Gustavo Freitas de Sousa Carvalho, Chrissie Ferreira de Nunes, Lorena S. Rodrigues, Juliana L. G. Ribeiro, Nathália S. Almeida, Diego A. de Ferreira, Junia R. Dutra Abreu, José Neander Silva Menezes Filho, José Antônio |
author_role |
author |
author2 |
Carvalho, Chrissie Ferreira de Nunes, Lorena S. Rodrigues, Juliana L. G. Ribeiro, Nathália S. Almeida, Diego A. de Ferreira, Junia R. Dutra Abreu, José Neander Silva Menezes Filho, José Antônio |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Viana, Gustavo Freitas de Sousa Carvalho, Chrissie Ferreira de Nunes, Lorena S. Rodrigues, Juliana L. G. Ribeiro, Nathália S. Almeida, Diego A. de Ferreira, Junia R. Dutra Abreu, José Neander Silva Menezes Filho, José Antônio |
dc.subject.por.fl_str_mv |
Manganese Biomarkers Neuropsychological effects Environmental exposure Hair Fingernail |
topic |
Manganese Biomarkers Neuropsychological effects Environmental exposure Hair Fingernail |
description |
Texto completo: acesso restrito. p.169–178 |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-03-20T16:25:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/17215 |
dc.identifier.issn.none.fl_str_mv |
0378-4274 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 231, n. 2 |
identifier_str_mv |
0378-4274 v. 231, n. 2 |
url |
http://repositorio.ufba.br/ri/handle/ri/17215 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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http://dx.doi.org/10.1016/j.toxlet.2014.06.018 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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UFBA |
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UFBA |
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Repositório Institucional da UFBA |
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Repositório Institucional da UFBA |
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