Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil

Detalhes bibliográficos
Autor(a) principal: Viana, Gustavo Freitas de Sousa
Data de Publicação: 2014
Outros Autores: Carvalho, Chrissie Ferreira de, Nunes, Lorena S., Rodrigues, Juliana L. G., Ribeiro, Nathália S., Almeida, Diego A. de, Ferreira, Junia R. Dutra, Abreu, José Neander Silva, Menezes Filho, José Antônio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/17215
Resumo: Texto completo: acesso restrito. p.169–178
id UFBA-2_2d5c864824d0db43851bf3b3eac9c6ee
oai_identifier_str oai:repositorio.ufba.br:ri/17215
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Viana, Gustavo Freitas de SousaCarvalho, Chrissie Ferreira deNunes, Lorena S.Rodrigues, Juliana L. G.Ribeiro, Nathália S.Almeida, Diego A. deFerreira, Junia R. DutraAbreu, José Neander SilvaMenezes Filho, José Antônio2015-03-20T16:25:42Z20140378-4274http://repositorio.ufba.br/ri/handle/ri/17215v. 231, n. 2Texto completo: acesso restrito. p.169–178Manganese (Mn), an essential element to humans, in excess can cause neurotoxic damage. So far, Mn exposure assessment has no ideal biomarker. This study aims to investigate the association between Mn exposure, using noninvasive biomarkers, and neuropsychological effects in environmentally exposed adults. The residents of two communities near to a ferromanganese refinery in Bahia, Brazil were evaluated. Volunteers aged 15–55 of both sexes provided scalp hair, axillary hair, fingernail and saliva specimens for Mn determination by electrothermal absorption spectrometry. Several neuropsychological tests were used to evaluate cognitive, attention, memory, motor and executive functions. Significant correlations were observed between Mn in hair (MnH, median 8.95 μg/g), axillary hair (MnAxH,18.49 μg/g) and fingernail (MnFN, 6.91 μg/g) with the performances in several neuropsychological tests. No association was observed between manganese levels in saliva (MnSal, 4.2 μg/L) and any neuropsychological function. Multiple regression analysis detected an inverse association between Log MnH and IQ (β = –4.76 [CI 95% –9.17 to –0.36]) and between Log MnFN and visual working memory (β = –3.33 [CI 95% –6.15 to –0.52]). Direct association was observed between Log MnFN and time of completion in the cognitive flexibility task (β = 56.29 [CI 95% 2.41–110.18]). The Mn biomonitoring using noninvasive biomarkers was able to detect high exposure levels, which were associated with detrimental neuropsychological effects in adults exposed to industrial emissions.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2015-03-18T15:57:33Z No. of bitstreams: 1 Gustavo F. de Sousa Viana.pdf: 807324 bytes, checksum: cafa2beac895da6317c03520c107228d (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2015-03-20T16:25:42Z (GMT) No. of bitstreams: 1 Gustavo F. de Sousa Viana.pdf: 807324 bytes, checksum: cafa2beac895da6317c03520c107228d (MD5)Made available in DSpace on 2015-03-20T16:25:42Z (GMT). No. of bitstreams: 1 Gustavo F. de Sousa Viana.pdf: 807324 bytes, checksum: cafa2beac895da6317c03520c107228d (MD5) Previous issue date: 2014http://dx.doi.org/10.1016/j.toxlet.2014.06.018reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAManganeseBiomarkersNeuropsychological effectsEnvironmental exposureHairFingernailNoninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in BrazilToxicology Lettersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALGustavo F. de Sousa Viana.pdfGustavo F. de Sousa Viana.pdfapplication/pdf807324https://repositorio.ufba.br/bitstream/ri/17215/1/Gustavo%20F.%20de%20Sousa%20Viana.pdfcafa2beac895da6317c03520c107228dMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/17215/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTGustavo F. de Sousa Viana.pdf.txtGustavo F. de Sousa Viana.pdf.txtExtracted texttext/plain58937https://repositorio.ufba.br/bitstream/ri/17215/3/Gustavo%20F.%20de%20Sousa%20Viana.pdf.txta5bda1df92a3e40bb9765263629e407aMD53ri/172152022-07-01 10:46:55.94oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-01T13:46:55Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil
dc.title.alternative.pt_BR.fl_str_mv Toxicology Letters
title Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil
spellingShingle Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil
Viana, Gustavo Freitas de Sousa
Manganese
Biomarkers
Neuropsychological effects
Environmental exposure
Hair
Fingernail
title_short Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil
title_full Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil
title_fullStr Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil
title_full_unstemmed Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil
title_sort Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil
author Viana, Gustavo Freitas de Sousa
author_facet Viana, Gustavo Freitas de Sousa
Carvalho, Chrissie Ferreira de
Nunes, Lorena S.
Rodrigues, Juliana L. G.
Ribeiro, Nathália S.
Almeida, Diego A. de
Ferreira, Junia R. Dutra
Abreu, José Neander Silva
Menezes Filho, José Antônio
author_role author
author2 Carvalho, Chrissie Ferreira de
Nunes, Lorena S.
Rodrigues, Juliana L. G.
Ribeiro, Nathália S.
Almeida, Diego A. de
Ferreira, Junia R. Dutra
Abreu, José Neander Silva
Menezes Filho, José Antônio
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Viana, Gustavo Freitas de Sousa
Carvalho, Chrissie Ferreira de
Nunes, Lorena S.
Rodrigues, Juliana L. G.
Ribeiro, Nathália S.
Almeida, Diego A. de
Ferreira, Junia R. Dutra
Abreu, José Neander Silva
Menezes Filho, José Antônio
dc.subject.por.fl_str_mv Manganese
Biomarkers
Neuropsychological effects
Environmental exposure
Hair
Fingernail
topic Manganese
Biomarkers
Neuropsychological effects
Environmental exposure
Hair
Fingernail
description Texto completo: acesso restrito. p.169–178
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-03-20T16:25:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/17215
dc.identifier.issn.none.fl_str_mv 0378-4274
dc.identifier.number.pt_BR.fl_str_mv v. 231, n. 2
identifier_str_mv 0378-4274
v. 231, n. 2
url http://repositorio.ufba.br/ri/handle/ri/17215
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.toxlet.2014.06.018
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/17215/1/Gustavo%20F.%20de%20Sousa%20Viana.pdf
https://repositorio.ufba.br/bitstream/ri/17215/2/license.txt
https://repositorio.ufba.br/bitstream/ri/17215/3/Gustavo%20F.%20de%20Sousa%20Viana.pdf.txt
bitstream.checksum.fl_str_mv cafa2beac895da6317c03520c107228d
ff6eaa8b858ea317fded99f125f5fcd0
a5bda1df92a3e40bb9765263629e407a
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459494844268544

Registros relacionados