American Cutaneous Leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-Methilglucamine Antimoniate plus Pentoxifylline

Detalhes bibliográficos
Autor(a) principal: Báfica, Andre Luiz Barbosa
Data de Publicação: 2003
Outros Autores: Oliveira, Luiz Fabiano Borges, Freitas, Luiz Antonio Rodrigues de, Nascimento, Eliane G., Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16672
Resumo: Texto completo: acesso restrito. p. 203–207
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spelling Báfica, Andre Luiz BarbosaOliveira, Luiz Fabiano BorgesFreitas, Luiz Antonio Rodrigues deNascimento, Eliane G.Barral, Aldina Maria PradoBáfica, Andre Luiz BarbosaOliveira, Luiz Fabiano BorgesFreitas, Luiz Antonio Rodrigues deNascimento, Eliane G.Barral, Aldina Maria Prado2014-11-28T15:40:33Z20030011-9059http://repositorio.ufba.br/ri/handle/ri/16672v. 42, n. 3Texto completo: acesso restrito. p. 203–207Background American cutaneous leishmaniasis is characterized by single or multiple ulcerations. Cytokines, among other factors, have been shown to influence lesion development and tumoral necrosis factor-alpha is a major cytokine implicated in pathogenesis of ulcers. Observations We tested oral pentoxifylline, a known tumoral necrosis factor-alpha inhibitor, at doses of 400 mg (2–3x/day), associated to N-methylglucamine antimoniate (15 mg/kg/day) in two patients with American cutaneous leishmaniasis unresponsive to antimonial drugs. We observed a satisfactory response with quick cure of skin lesions of these patients. Conclusions Our results suggest that oral pentoxifylline in association to N-methylglucamine antimoniate should be consider in refractory cutaneous leishmaniasis patients.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-01-13T13:41:46Z No. of bitstreams: 1 André Báfica.pdf: 242239 bytes, checksum: 11179b434c51c965c7444dc03b6fe533 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-11-28T15:40:33Z (GMT) No. of bitstreams: 1 André Báfica.pdf: 242239 bytes, checksum: 11179b434c51c965c7444dc03b6fe533 (MD5)Made available in DSpace on 2014-11-28T15:40:33Z (GMT). No. of bitstreams: 1 André Báfica.pdf: 242239 bytes, checksum: 11179b434c51c965c7444dc03b6fe533 (MD5) Previous issue date: 2003http://dx.doi.org/ 10.1046/j.1365-4362.2003.01868.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmaniasis, CutaneousUlcerPentoxifyllineAmerican Cutaneous Leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-Methilglucamine Antimoniate plus PentoxifyllineInternational Journal of Dermatologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16672/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52ORIGINALAndré Báfica.pdfAndré Báfica.pdfapplication/pdf242239https://repositorio.ufba.br/bitstream/ri/16672/1/Andr%c3%a9%20B%c3%a1fica.pdf11179b434c51c965c7444dc03b6fe533MD51TEXTAndré Báfica.pdf.txtAndré Báfica.pdf.txtExtracted texttext/plain15516https://repositorio.ufba.br/bitstream/ri/16672/3/Andr%c3%a9%20B%c3%a1fica.pdf.txte28dc3e35c12df3b7a0d257a4f7b4d74MD53ri/166722022-08-08 13:17:37.453oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:37Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv American Cutaneous Leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-Methilglucamine Antimoniate plus Pentoxifylline
dc.title.alternative.pt_BR.fl_str_mv International Journal of Dermatology
title American Cutaneous Leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-Methilglucamine Antimoniate plus Pentoxifylline
spellingShingle American Cutaneous Leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-Methilglucamine Antimoniate plus Pentoxifylline
Báfica, Andre Luiz Barbosa
Leishmaniasis, Cutaneous
Ulcer
Pentoxifylline
title_short American Cutaneous Leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-Methilglucamine Antimoniate plus Pentoxifylline
title_full American Cutaneous Leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-Methilglucamine Antimoniate plus Pentoxifylline
title_fullStr American Cutaneous Leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-Methilglucamine Antimoniate plus Pentoxifylline
title_full_unstemmed American Cutaneous Leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-Methilglucamine Antimoniate plus Pentoxifylline
title_sort American Cutaneous Leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-Methilglucamine Antimoniate plus Pentoxifylline
author Báfica, Andre Luiz Barbosa
author_facet Báfica, Andre Luiz Barbosa
Oliveira, Luiz Fabiano Borges
Freitas, Luiz Antonio Rodrigues de
Nascimento, Eliane G.
Barral, Aldina Maria Prado
author_role author
author2 Oliveira, Luiz Fabiano Borges
Freitas, Luiz Antonio Rodrigues de
Nascimento, Eliane G.
Barral, Aldina Maria Prado
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Báfica, Andre Luiz Barbosa
Oliveira, Luiz Fabiano Borges
Freitas, Luiz Antonio Rodrigues de
Nascimento, Eliane G.
Barral, Aldina Maria Prado
Báfica, Andre Luiz Barbosa
Oliveira, Luiz Fabiano Borges
Freitas, Luiz Antonio Rodrigues de
Nascimento, Eliane G.
Barral, Aldina Maria Prado
dc.subject.por.fl_str_mv Leishmaniasis, Cutaneous
Ulcer
Pentoxifylline
topic Leishmaniasis, Cutaneous
Ulcer
Pentoxifylline
description Texto completo: acesso restrito. p. 203–207
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2014-11-28T15:40:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16672
dc.identifier.issn.none.fl_str_mv 0011-9059
dc.identifier.number.pt_BR.fl_str_mv v. 42, n. 3
identifier_str_mv 0011-9059
v. 42, n. 3
url http://repositorio.ufba.br/ri/handle/ri/16672
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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