Pentoxifylline down modulate in vitro Tcell responses and attenuate pathology in Leishmania and HTLV-I infections

Detalhes bibliográficos
Autor(a) principal: Jesus, Amelia Ribeiro de
Data de Publicação: 2008
Outros Autores: Luna, Tania, Almeida, Roque Pacheco de, Machado, Paulo Roberto Lima, Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6032
Resumo: Acesso restrito: Texto completo. p. 1344-1353.
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spelling Jesus, Amelia Ribeiro deLuna, TaniaAlmeida, Roque Pacheco deMachado, Paulo Roberto LimaCarvalho Filho, Edgar Marcelino deJesus, Amelia Ribeiro deLuna, TaniaAlmeida, Roque Pacheco deMachado, Paulo Roberto LimaCarvalho Filho, Edgar Marcelino de2012-05-31T18:39:31Z20081567-5769http://www.repositorio.ufba.br/ri/handle/ri/6032v. 8, n. 10Acesso restrito: Texto completo. p. 1344-1353.Tumor necrosis factor-α (TNF-α) is known to have numerous biological properties relating to inflammation. This cytokine participates in the tissue damage of chronic inflammatory, autoimmune and infectious diseases. Pentoxifylline is a methylxanthine that inhibits phosphodiesterase IV, which inhibits the degradation of the cAMP and prostanoids. The increased intracellular concentration of the cAMP leads to a negative regulation of NF-κB and NF-AT transcription factors and suppresses TNF-α production. This review describes studies that support evidences that TNF-α is involved in the pathogenesis of HTLV-1 associated myelopathy and of cutaneous and mucosal leishmaniasis. Additionally, it demonstrates the effect of pentoxifylline in vitro in inhibiting TNF-α and IFN-γ spontaneous production in PBMC from HTLV-1-infected patients, as well as its in vivo effect in inhibiting TNF-α in sera from mucosal leishmaniasis patients. Moreover, we review the results of clinical studies from the last 10 years using pentoxifylline to treat HTLV-1 associated myelopathy and cutaneous and mucosal leishmaniasis. © 2008 Elsevier B.V. All rights reserved.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-31T18:39:30Z No. of bitstreams: 1 __ac.els-cdn.com_S156757...aef58ae20dfe7e23572a12687811e.pdf: 312599 bytes, checksum: 344280ac999c14a518e98e0807d71b68 (MD5)Made available in DSpace on 2012-05-31T18:39:31Z (GMT). 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dc.title.pt_BR.fl_str_mv Pentoxifylline down modulate in vitro Tcell responses and attenuate pathology in Leishmania and HTLV-I infections
dc.title.alternative.pt_BR.fl_str_mv International Immunopharmacology 
title Pentoxifylline down modulate in vitro Tcell responses and attenuate pathology in Leishmania and HTLV-I infections
spellingShingle Pentoxifylline down modulate in vitro Tcell responses and attenuate pathology in Leishmania and HTLV-I infections
Jesus, Amelia Ribeiro de
Pentoxifylline
HTLV-1
Leishmaniasis
Cutaneous leishmaniasis
Mucosal leishmaniasis
Immunotherapy
title_short Pentoxifylline down modulate in vitro Tcell responses and attenuate pathology in Leishmania and HTLV-I infections
title_full Pentoxifylline down modulate in vitro Tcell responses and attenuate pathology in Leishmania and HTLV-I infections
title_fullStr Pentoxifylline down modulate in vitro Tcell responses and attenuate pathology in Leishmania and HTLV-I infections
title_full_unstemmed Pentoxifylline down modulate in vitro Tcell responses and attenuate pathology in Leishmania and HTLV-I infections
title_sort Pentoxifylline down modulate in vitro Tcell responses and attenuate pathology in Leishmania and HTLV-I infections
author Jesus, Amelia Ribeiro de
author_facet Jesus, Amelia Ribeiro de
Luna, Tania
Almeida, Roque Pacheco de
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Luna, Tania
Almeida, Roque Pacheco de
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Jesus, Amelia Ribeiro de
Luna, Tania
Almeida, Roque Pacheco de
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
Jesus, Amelia Ribeiro de
Luna, Tania
Almeida, Roque Pacheco de
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv Pentoxifylline
HTLV-1
Leishmaniasis
Cutaneous leishmaniasis
Mucosal leishmaniasis
Immunotherapy
topic Pentoxifylline
HTLV-1
Leishmaniasis
Cutaneous leishmaniasis
Mucosal leishmaniasis
Immunotherapy
description Acesso restrito: Texto completo. p. 1344-1353.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-05-31T18:39:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6032
dc.identifier.issn.none.fl_str_mv 1567-5769
dc.identifier.number.pt_BR.fl_str_mv v. 8, n. 10
identifier_str_mv 1567-5769
v. 8, n. 10
url http://www.repositorio.ufba.br/ri/handle/ri/6032
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.intimp.2008.03.020
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
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reponame_str Repositório Institucional da UFBA
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