Regression Splines in the Time-Dependent Coefficient Rates

Detalhes bibliográficos
Autor(a) principal: Amorim, Leila Denise Alves Ferreira
Data de Publicação: 2008
Outros Autores: Cai, Jianwen, Zeng, Donglin, Barreto, Mauricio Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/2124
Resumo: p.1-13
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spelling Amorim, Leila Denise Alves FerreiraCai, JianwenZeng, DonglinBarreto, Mauricio LimaAmorim, Leila Denise Alves FerreiraCai, JianwenZeng, DonglinBarreto, Mauricio Lima2011-08-10T19:56:43Z2011-08-10T19:56:43Z2008-12-10http://www.repositorio.ufba.br/ri/handle/ri/212427(28): 5890–5906p.1-13Many epidemiologic studies involve the occurrence of recurrent events and much attention has been given for the development of modelling techniques that take into account the dependence structure of multiple event data. This paper presents a time -dependent coefficient rates model that incorporates regression splines in its estimation procedure. Such method would be appropriate in situations where the effect of an exposure or covariates changes over time in recurrent event data settings. The finite sample properties of the estimators are studied via simulation. Using data from a randomized community trial that was designed to evaluate the effect of vitamin A supplementation on recurrent diarrheal episodes in small children, we model the functional form of the treatment effect on the time to the occurrence of diarrhea. The results describe how this effect varies over time. In summary, we observed a major impact of the vitamin A supplementation on diarrhea after 2 months of the dosage, with the effect diminishing after the third dosage. The proposed method can be viewed as a flexible alternative to the marginal rates model with constant effect in situations where the effect of interest may vary over time.Submitted by Rigaud Andréa (andrearigaud16@yahoo.com.br) on 2011-08-10T19:56:43Z No. of bitstreams: 1 per%20int2008.14[1].pdf: 562560 bytes, checksum: 9d87dcec1b88cf914aa423d3e8efbb86 (MD5)Made available in DSpace on 2011-08-10T19:56:43Z (GMT). No. of bitstreams: 1 per%20int2008.14[1].pdf: 562560 bytes, checksum: 9d87dcec1b88cf914aa423d3e8efbb86 (MD5) Previous issue date: 2008-12-10Regression Splines in the Time-Dependent Coefficient RatesStat Med.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALper%20int2008.14[1].pdfper%20int2008.14[1].pdfapplication/pdf562560https://repositorio.ufba.br/bitstream/ri/2124/1/per%2520int2008.14%5b1%5d.pdf9d87dcec1b88cf914aa423d3e8efbb86MD51LICENSElicense.txtlicense.txttext/plain1906https://repositorio.ufba.br/bitstream/ri/2124/2/license.txta7a4f140135605fa80a6d49b406fbb77MD52TEXTper%20int2008.14[1].pdf.txtper%20int2008.14[1].pdf.txtExtracted texttext/plain46649https://repositorio.ufba.br/bitstream/ri/2124/3/per%2520int2008.14%5b1%5d.pdf.txt1dfb6bdfdc1c6e42bcd0c6e83f6e2f50MD53ri/21242022-08-08 13:17:27.826oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:27Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Regression Splines in the Time-Dependent Coefficient Rates
dc.title.alternative.pt_BR.fl_str_mv Stat Med.
title Regression Splines in the Time-Dependent Coefficient Rates
spellingShingle Regression Splines in the Time-Dependent Coefficient Rates
Amorim, Leila Denise Alves Ferreira
title_short Regression Splines in the Time-Dependent Coefficient Rates
title_full Regression Splines in the Time-Dependent Coefficient Rates
title_fullStr Regression Splines in the Time-Dependent Coefficient Rates
title_full_unstemmed Regression Splines in the Time-Dependent Coefficient Rates
title_sort Regression Splines in the Time-Dependent Coefficient Rates
author Amorim, Leila Denise Alves Ferreira
author_facet Amorim, Leila Denise Alves Ferreira
Cai, Jianwen
Zeng, Donglin
Barreto, Mauricio Lima
author_role author
author2 Cai, Jianwen
Zeng, Donglin
Barreto, Mauricio Lima
author2_role author
author
author
dc.contributor.author.fl_str_mv Amorim, Leila Denise Alves Ferreira
Cai, Jianwen
Zeng, Donglin
Barreto, Mauricio Lima
Amorim, Leila Denise Alves Ferreira
Cai, Jianwen
Zeng, Donglin
Barreto, Mauricio Lima
description p.1-13
publishDate 2008
dc.date.issued.fl_str_mv 2008-12-10
dc.date.accessioned.fl_str_mv 2011-08-10T19:56:43Z
dc.date.available.fl_str_mv 2011-08-10T19:56:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/2124
dc.identifier.number.pt_BR.fl_str_mv 27(28): 5890–5906
url http://www.repositorio.ufba.br/ri/handle/ri/2124
identifier_str_mv 27(28): 5890–5906
dc.language.iso.fl_str_mv eng
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