Association between an Emerging Disseminated form of Leishmaniasis and Leishmania (Viannia) braziliensis Strain Polymorphisms
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14919 |
Resumo: | Texto completo: acesso restrito. p. 4028-4034 |
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Queiroz, AdrianoSousa, Rosana SantosCarvalho Filho, Edgar Marcelino deHeine, ClaudiaCardoso, Manuela PedraGuimarães, Luiz HenriqueMachado, Paulo Roberto LimaRiley, Lee W.Wilson, Mary E.Schriefer, Nicolaus Albert BorgesQueiroz, AdrianoSousa, Rosana SantosCarvalho Filho, Edgar Marcelino deHeine, ClaudiaCardoso, Manuela PedraGuimarães, Luiz HenriqueMachado, Paulo Roberto LimaRiley, Lee W.Wilson, Mary E.Schriefer, Nicolaus Albert Borges2014-05-06T14:14:29Z20120095-1137http://repositorio.ufba.br/ri/handle/ri/14919v. 50, n. 12Texto completo: acesso restrito. p. 4028-4034Leishmania (Viannia) braziliensis causes three main types of American tegumentary leishmaniasis (ATL), localized cutaneous leishmaniasis (CL), mucosal leishmaniasis (ML), and disseminated leishmaniasis (DL). All forms are observed among individuals of Corte de Pedra, Brazil. We previously used random amplified markers to identify a multiclonal population among L. (V.) braziliensis isolates from ATL patients, defining parasite clades associated with different clinical syndromes. Herein we compared sequences of random amplified markers to identify genotypes of L. (V.) braziliensis recovered from lesions of CL, ML, and DL patients. Six polymorphic genomic loci were sequenced from 35 parasite isolates. Single-nucleotide polymorphisms (SNPs) and insertions-deletions (indels) at each locus allowed us to segregate the L. (V.) braziliensis population according to haplotypes. Several SNPs, indels, and haplotypes were significantly associated with an increased risk of DL. Molecular genotyping may provide markers to identify L. (V.) braziliensis strains likely to cause this emerging, hard-to-treat form of ATL.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-05-06T14:14:29Z No. of bitstreams: 1 Adriano Queiroz.pdf: 323786 bytes, checksum: 400d2c446c8951961022886d1ab58b09 (MD5)Made available in DSpace on 2014-05-06T14:14:29Z (GMT). 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| dc.title.pt_BR.fl_str_mv |
Association between an Emerging Disseminated form of Leishmaniasis and Leishmania (Viannia) braziliensis Strain Polymorphisms |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Clinical Microbiology |
| title |
Association between an Emerging Disseminated form of Leishmaniasis and Leishmania (Viannia) braziliensis Strain Polymorphisms |
| spellingShingle |
Association between an Emerging Disseminated form of Leishmaniasis and Leishmania (Viannia) braziliensis Strain Polymorphisms Queiroz, Adriano |
| title_short |
Association between an Emerging Disseminated form of Leishmaniasis and Leishmania (Viannia) braziliensis Strain Polymorphisms |
| title_full |
Association between an Emerging Disseminated form of Leishmaniasis and Leishmania (Viannia) braziliensis Strain Polymorphisms |
| title_fullStr |
Association between an Emerging Disseminated form of Leishmaniasis and Leishmania (Viannia) braziliensis Strain Polymorphisms |
| title_full_unstemmed |
Association between an Emerging Disseminated form of Leishmaniasis and Leishmania (Viannia) braziliensis Strain Polymorphisms |
| title_sort |
Association between an Emerging Disseminated form of Leishmaniasis and Leishmania (Viannia) braziliensis Strain Polymorphisms |
| author |
Queiroz, Adriano |
| author_facet |
Queiroz, Adriano Sousa, Rosana Santos Carvalho Filho, Edgar Marcelino de Heine, Claudia Cardoso, Manuela Pedra Guimarães, Luiz Henrique Machado, Paulo Roberto Lima Riley, Lee W. Wilson, Mary E. Schriefer, Nicolaus Albert Borges |
| author_role |
author |
| author2 |
Sousa, Rosana Santos Carvalho Filho, Edgar Marcelino de Heine, Claudia Cardoso, Manuela Pedra Guimarães, Luiz Henrique Machado, Paulo Roberto Lima Riley, Lee W. Wilson, Mary E. Schriefer, Nicolaus Albert Borges |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Queiroz, Adriano Sousa, Rosana Santos Carvalho Filho, Edgar Marcelino de Heine, Claudia Cardoso, Manuela Pedra Guimarães, Luiz Henrique Machado, Paulo Roberto Lima Riley, Lee W. Wilson, Mary E. Schriefer, Nicolaus Albert Borges Queiroz, Adriano Sousa, Rosana Santos Carvalho Filho, Edgar Marcelino de Heine, Claudia Cardoso, Manuela Pedra Guimarães, Luiz Henrique Machado, Paulo Roberto Lima Riley, Lee W. Wilson, Mary E. Schriefer, Nicolaus Albert Borges |
| description |
Texto completo: acesso restrito. p. 4028-4034 |
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2012 |
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2012 |
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2014-05-06T14:14:29Z |
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0095-1137 |
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v. 50, n. 12 |
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0095-1137 v. 50, n. 12 |
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