Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis

Detalhes bibliográficos
Autor(a) principal: Magalhães, Andréa
Data de Publicação: 2021
Outros Autores: Carvalho, Lucas Pedreira de, Costa, Rúbia, Pita, Mônica S., Cardoso, Thiago Marconi, Machado, Paulo Roberto Lima, Carvalho, Edgar Marcelino de, Arruda, Sérgio Marcos, Carvalho, Augusto M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46587
Resumo: National Institutes of Health grant AI 136032.
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spelling Magalhães, AndréaCarvalho, Lucas Pedreira deCosta, RúbiaPita, Mônica S.Cardoso, Thiago MarconiMachado, Paulo Roberto LimaCarvalho, Edgar Marcelino deArruda, Sérgio MarcosCarvalho, Augusto M.2021-04-09T11:40:35Z2021-04-09T11:40:35Z2021MAGALHÃES, Andréa et al. Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis. International Journal of Infectious Diseases, 2021.https://www.arca.fiocruz.br/handle/icict/46587National Institutes of Health grant AI 136032.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil.Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.In this study we determine the accuracy of anti-Leishmania IgG and IgG subclasses to distinguish clinical forms of American tegumentary leishmaniasis (ATL), and the relationship between antibodies levels with cytokine production and severity of ATL. Methods: Participants were 40 cutaneous leishmaniasis (CL), 20 mucosal leishmaniasis (ML), 20 disseminated leishmaniasis (DL) patients and 20 subjects with subclinical L. braziliensis infection (SC). Diagnosis was performed by DNA of L. braziliensis or IFN-γ production in SC. IgG and subclasses of IgG to soluble Leishmania antigen, as well cytokine levels in supernatants of mononuclear cells were detected by ELISA. Results: IgG were detected in 95%, 95% and 100% of CL, ML and DL patients, respectively. Higher levels of anti-Leishmania IgG and IgG2 were seen in DL compared to CL, ML and SC. ROC analysis confirmed the ability of IgG to distinguish DL from the other clinical forms. A direct correlation was observed between IgG titers and levels of IFN-γ and CXCL10 in CL and DL, and IgG2 antibodies correlated with the number of lesions in DL. Conclusions: High Anti-Leishmania IgG and IgG2 levels are characteristic of DL, and while IgG was correlated with pro-inflammatory cytokines, IgG2 was direct correlated with number of lesions.engElsevierLeishmaniose cutâneaLeishmania braziliensisIgGIgG2Gravidade da doençaCutaneous leishmaniasisDisseminated leishmaniasisLeishmania braziliensisIgGIgG2Disease severityAnti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46587/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALMagalhães, Andrea Anti-Leishmania....pdfMagalhães, Andrea 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dc.title.pt_BR.fl_str_mv Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis
title Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis
spellingShingle Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis
Magalhães, Andréa
Leishmaniose cutânea
Leishmania braziliensis
IgG
IgG2
Gravidade da doença
Cutaneous leishmaniasis
Disseminated leishmaniasis
Leishmania braziliensis
IgG
IgG2
Disease severity
title_short Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis
title_full Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis
title_fullStr Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis
title_full_unstemmed Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis
title_sort Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis
author Magalhães, Andréa
author_facet Magalhães, Andréa
Carvalho, Lucas Pedreira de
Costa, Rúbia
Pita, Mônica S.
Cardoso, Thiago Marconi
Machado, Paulo Roberto Lima
Carvalho, Edgar Marcelino de
Arruda, Sérgio Marcos
Carvalho, Augusto M.
author_role author
author2 Carvalho, Lucas Pedreira de
Costa, Rúbia
Pita, Mônica S.
Cardoso, Thiago Marconi
Machado, Paulo Roberto Lima
Carvalho, Edgar Marcelino de
Arruda, Sérgio Marcos
Carvalho, Augusto M.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Magalhães, Andréa
Carvalho, Lucas Pedreira de
Costa, Rúbia
Pita, Mônica S.
Cardoso, Thiago Marconi
Machado, Paulo Roberto Lima
Carvalho, Edgar Marcelino de
Arruda, Sérgio Marcos
Carvalho, Augusto M.
dc.subject.other.pt_BR.fl_str_mv Leishmaniose cutânea
Leishmania braziliensis
IgG
IgG2
Gravidade da doença
topic Leishmaniose cutânea
Leishmania braziliensis
IgG
IgG2
Gravidade da doença
Cutaneous leishmaniasis
Disseminated leishmaniasis
Leishmania braziliensis
IgG
IgG2
Disease severity
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
Disseminated leishmaniasis
Leishmania braziliensis
IgG
IgG2
Disease severity
description National Institutes of Health grant AI 136032.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-09T11:40:35Z
dc.date.available.fl_str_mv 2021-04-09T11:40:35Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAGALHÃES, Andréa et al. Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis. International Journal of Infectious Diseases, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46587
identifier_str_mv MAGALHÃES, Andréa et al. Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis. International Journal of Infectious Diseases, 2021.
url https://www.arca.fiocruz.br/handle/icict/46587
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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