Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery

Bibliographic Details
Main Author: Andrade, Antônio Ricardo de
Publication Date: 2008
Other Authors: Cotrim, Helma Pinchemel, Alves, Erivaldo, Soares, Daniela, Rocha, Raquel, Almeida, Alessandro de Moura, Almeida, Carolina G., Freitas, Luiz Antonio de
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://www.repositorio.ufba.br/ri/handle/ri/4779
Summary: p.364-368
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spelling Andrade, Antônio Ricardo deCotrim, Helma PinchemelAlves, ErivaldoSoares, DanielaRocha, RaquelAlmeida, Alessandro de MouraAlmeida, Carolina G.Freitas, Luiz Antonio deAndrade, Antônio Ricardo deCotrim, Helma PinchemelAlves, ErivaldoSoares, DanielaRocha, RaquelAlmeida, Alessandro de MouraAlmeida, Carolina G.Freitas, Luiz Antonio de2011-12-06T13:04:00Z2011-12-06T13:04:00Z20081665-2681http://www.repositorio.ufba.br/ri/handle/ri/47797(4)p.364-368Background: Obesity is the most frequent risk factor associated with NAFLD, and bariatric surgery (BAS) is traditionally indicated for the treatment of severely obese individuals. Here, we discuss the behavior and prognosis of this liver disease following post-surgical weight loss. Aim: To evaluate the influence of the BAS on the clinical and biochemical parameters of NAFLD in severely obese patients. Methodology: An intervention study included obese individuals (BMI≥ 35kg/m2), who had been submitted to liver biopsy during BAS and had NAFLD. HAIR (hypertension, ALT and insulin resistance and BAAT (BMI, ALT, age and triglycerides) scores and FLI (Fatty Liver Index) were used to compare the patients at the time of surgery, and 12-30 months following weight loss. Results: From October 2004 to September 2007, 122 patients were diagnosed with NAFLD, 40 of whom agreed to participate in the study. The mean age was 37.7 ± 12.5 years, 60% were women and 80% had steatohepatitis (NASH) with fibrosis upon analysis of the liver biopsy performed during BAS. Mean weight loss was 46.0 ± 2.0 kg. After 21 ± 5.8 months of follow-up, a significant improvement was found in all the variables analyzed (79.3% according to the HAIR scores, 95.2% as measured by the BAAT score and 72.5% by the FLI. Conclusion: The results suggest that treatment of obesity by bariatric surgery may influence the prognosis of NAFLD. In addition to weight loss, we observed improvement in the clinical and biochemical parameters related to NAFLD, such as anthropometrics index, hypertension, aminotransferases, triglycerides and insulin resistance.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2011-12-06T13:04:00Z No. of bitstreams: 1 ah084i.pdf: 125137 bytes, checksum: 4363f9b20414ea44f7b21e2a0e9f6765 (MD5)Made available in DSpace on 2011-12-06T13:04:00Z (GMT). No. of bitstreams: 1 ah084i.pdf: 125137 bytes, checksum: 4363f9b20414ea44f7b21e2a0e9f6765 (MD5) Previous issue date: 2008Nonalcoholic steatohepatitis (NASH)morbid obesitymetabolic syndromeinsulin resistanceobesityNonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgeryAnnals of hepatologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALah084i.pdfah084i.pdfapplication/pdf125137https://repositorio.ufba.br/bitstream/ri/4779/1/ah084i.pdf4363f9b20414ea44f7b21e2a0e9f6765MD51LICENSElicense.txtlicense.txttext/plain1748https://repositorio.ufba.br/bitstream/ri/4779/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTah084i.pdf.txtah084i.pdf.txtExtracted texttext/plain24505https://repositorio.ufba.br/bitstream/ri/4779/3/ah084i.pdf.txta3721e4ae13df93e625a26f03f4f9232MD53ri/47792022-07-05 14:03:16.144oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:16Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery
dc.title.alternative.pt_BR.fl_str_mv Annals of hepatology
title Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery
spellingShingle Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery
Andrade, Antônio Ricardo de
Nonalcoholic steatohepatitis (NASH)
morbid obesity
metabolic syndrome
insulin resistance
obesity
title_short Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery
title_full Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery
title_fullStr Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery
title_full_unstemmed Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery
title_sort Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery
author Andrade, Antônio Ricardo de
author_facet Andrade, Antônio Ricardo de
Cotrim, Helma Pinchemel
Alves, Erivaldo
Soares, Daniela
Rocha, Raquel
Almeida, Alessandro de Moura
Almeida, Carolina G.
Freitas, Luiz Antonio de
author_role author
author2 Cotrim, Helma Pinchemel
Alves, Erivaldo
Soares, Daniela
Rocha, Raquel
Almeida, Alessandro de Moura
Almeida, Carolina G.
Freitas, Luiz Antonio de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Antônio Ricardo de
Cotrim, Helma Pinchemel
Alves, Erivaldo
Soares, Daniela
Rocha, Raquel
Almeida, Alessandro de Moura
Almeida, Carolina G.
Freitas, Luiz Antonio de
Andrade, Antônio Ricardo de
Cotrim, Helma Pinchemel
Alves, Erivaldo
Soares, Daniela
Rocha, Raquel
Almeida, Alessandro de Moura
Almeida, Carolina G.
Freitas, Luiz Antonio de
dc.subject.por.fl_str_mv Nonalcoholic steatohepatitis (NASH)
morbid obesity
metabolic syndrome
insulin resistance
obesity
topic Nonalcoholic steatohepatitis (NASH)
morbid obesity
metabolic syndrome
insulin resistance
obesity
description p.364-368
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2011-12-06T13:04:00Z
dc.date.available.fl_str_mv 2011-12-06T13:04:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/4779
dc.identifier.issn.none.fl_str_mv 1665-2681
dc.identifier.number.pt_BR.fl_str_mv 7(4)
identifier_str_mv 1665-2681
7(4)
url http://www.repositorio.ufba.br/ri/handle/ri/4779
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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