Effect of third ventricle administration of L-694,247, a selective 5-HT1(D) receptor agonist, on water intake in rats

Detalhes bibliográficos
Autor(a) principal: Silva, E. de Castro e
Data de Publicação: 1997
Outros Autores: Sarmento, Clarissa, Nascimento, T. A., Luz, C. P., Soares, T., Marinho, C. A., Cunha, M., Bulcão, C., Oliveira, I. R. de, Fregoneze, J. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8320
Resumo: Texto completo: acesso restrito. p.749–754
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spelling Silva, E. de Castro eSarmento, ClarissaNascimento, T. A.Luz, C. P.Soares, T.Marinho, C. A.Cunha, M.Bulcão, C.Oliveira, I. R. deFregoneze, J. B.Silva, E. de Castro eSarmento, ClarissaNascimento, T. A.Luz, C. P.Soares, T.Marinho, C. A.Cunha, M.Bulcão, C.Oliveira, I. R. deFregoneze, J. B.2013-02-01T11:57:25Z19970091-3057http://www.repositorio.ufba.br/ri/handle/ri/8320v. 57, n. 4Texto completo: acesso restrito. p.749–754DE CASTRO-E-SILVA, E., C. SARMENTO, T. A. NASCIMENTO, C. P. LUZ, T. SOARES, C. A. MARINHO, M. CUNHA, C. BULCÃO, I. R. DE OLIVEIRA AND J. B. FREGONEZE. Effect of third ventricle administration of L-694,247, a selective 5-HT1D receptor agonist, on water intake in rats. PHARMACOL BIOCHEM BEHAV 57[4]749–754, 1997.—L-694,247, a selective 5-HT1D receptor agonist, injected directly into the third ventricle (2.5, 5.0, and 10.0 μg/rat) of dehydrated rats induced a dose-dependent partial blockade of water intake. Injected in this way, the compound abolishes drinking behavior induced by third ventricle administration of carbachol (2 μg/rat), angiotensin II (5 ng/rat), and isoproterenol (40 μg/rat). In addition, intraventricular injections of L-694,247 did not modify water intake in normohydrated rats. The effects of L-694,247 are due to a specific interaction with 5-HT1D receptors, because its inhibitory effect on water intake in dehydrated rats is blocked by the previous administration of a 5-HT1D antagonist, GR 127935 (5 μg/rat), directly into the third ventricle. It is concluded that central 5-HT1D receptor activation disrupts the functional integrity of central pathways related to drinking behavior.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-02-01T11:57:25Z No. of bitstreams: 1 -SILVA.pdf: 252821 bytes, checksum: 841efc1839f806a8b2ad9e05d8af69b7 (MD5)Made available in DSpace on 2013-02-01T11:57:25Z (GMT). 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dc.title.pt_BR.fl_str_mv Effect of third ventricle administration of L-694,247, a selective 5-HT1(D) receptor agonist, on water intake in rats
dc.title.alternative.pt_BR.fl_str_mv Pharmacology Biochemistry and Behavior
title Effect of third ventricle administration of L-694,247, a selective 5-HT1(D) receptor agonist, on water intake in rats
spellingShingle Effect of third ventricle administration of L-694,247, a selective 5-HT1(D) receptor agonist, on water intake in rats
Silva, E. de Castro e
5-HT1D receptors
Serotonin
Angiotensin II
Adrenoceptors
Cholinergic receptors
Drinking behavior
title_short Effect of third ventricle administration of L-694,247, a selective 5-HT1(D) receptor agonist, on water intake in rats
title_full Effect of third ventricle administration of L-694,247, a selective 5-HT1(D) receptor agonist, on water intake in rats
title_fullStr Effect of third ventricle administration of L-694,247, a selective 5-HT1(D) receptor agonist, on water intake in rats
title_full_unstemmed Effect of third ventricle administration of L-694,247, a selective 5-HT1(D) receptor agonist, on water intake in rats
title_sort Effect of third ventricle administration of L-694,247, a selective 5-HT1(D) receptor agonist, on water intake in rats
author Silva, E. de Castro e
author_facet Silva, E. de Castro e
Sarmento, Clarissa
Nascimento, T. A.
Luz, C. P.
Soares, T.
Marinho, C. A.
Cunha, M.
Bulcão, C.
Oliveira, I. R. de
Fregoneze, J. B.
author_role author
author2 Sarmento, Clarissa
Nascimento, T. A.
Luz, C. P.
Soares, T.
Marinho, C. A.
Cunha, M.
Bulcão, C.
Oliveira, I. R. de
Fregoneze, J. B.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, E. de Castro e
Sarmento, Clarissa
Nascimento, T. A.
Luz, C. P.
Soares, T.
Marinho, C. A.
Cunha, M.
Bulcão, C.
Oliveira, I. R. de
Fregoneze, J. B.
Silva, E. de Castro e
Sarmento, Clarissa
Nascimento, T. A.
Luz, C. P.
Soares, T.
Marinho, C. A.
Cunha, M.
Bulcão, C.
Oliveira, I. R. de
Fregoneze, J. B.
dc.subject.por.fl_str_mv 5-HT1D receptors
Serotonin
Angiotensin II
Adrenoceptors
Cholinergic receptors
Drinking behavior
topic 5-HT1D receptors
Serotonin
Angiotensin II
Adrenoceptors
Cholinergic receptors
Drinking behavior
description Texto completo: acesso restrito. p.749–754
publishDate 1997
dc.date.issued.fl_str_mv 1997
dc.date.accessioned.fl_str_mv 2013-02-01T11:57:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8320
dc.identifier.issn.none.fl_str_mv 0091-3057
dc.identifier.number.pt_BR.fl_str_mv v. 57, n. 4
identifier_str_mv 0091-3057
v. 57, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/8320
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