Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2002 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/7469 |
Resumo: | Texto completo: acesso restrito. p. 891-898 |
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Castro, L.Maldonado, I.Campos, IgorVarjão, B.Angelo, Ana Luiza DiasAthanazio, Rodrigo AbensurBarbetta, Marcelo CamposRamos, A. C.Fregoneze, Josmara BartolomeiSilva, E. de Castro eCastro, L.Maldonado, I.Campos, IgorVarjão, B.Angelo, Ana Luiza DiasAthanazio, Rodrigo AbensurBarbetta, Marcelo CamposRamos, A. C.Fregoneze, Josmara BartolomeiSilva, E. de Castro e2012-12-12T18:24:29Z20020091-3057http://www.repositorio.ufba.br/ri/handle/ri/7469v. 72, n. 4Texto completo: acesso restrito. p. 891-898In the present study, we investigated in rats the effect of third ventricle injections of 1-(3-chlorophenyl)piperazine (mCPP), a 5-HT2 receptor agonist, on water intake induced by three different physiological stimuli: fluid deprivation, acute salt load and hypovolemia. Injections of mCPP in the doses of 80 and 160 nmol/rat were able to decrease water intake in all three conditions studied. Third ventricle injections of mCPP (160 nmol/rat) were no longer able to diminish water intake in the groups of rats pretreated with central injections of an equimolar amount of (+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10 methylindolo[1,7-bc][2,6]-naphthyridine (SDZ SER 082), a selective 5-HT2B/2C antagonist. The central administration of mCPP (160 nmol/rat) was not able to modify the intake of a 0.1% saccharin solution. It is suggested that the central activation of a 5-HT2B/2C component is able to impair the drive for water intake induced by the physiological stimuli represented by fluid deprivation, acute salt load and hypovolemia. This effect seems not to be consequent on a general nonspecific central nervous system depression or on a locomotor deficit, because saccharin intake is not affected by third ventricle injections of mCPP.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2012-12-12T18:24:29Z No. of bitstreams: 1 1-s2.0-S0197245602002167-main.pdf: 183560 bytes, checksum: cf52579b2c114d28d3c3873ca0a37e72 (MD5)Made available in DSpace on 2012-12-12T18:24:29Z (GMT). No. of bitstreams: 1 1-s2.0-S0197245602002167-main.pdf: 183560 bytes, checksum: cf52579b2c114d28d3c3873ca0a37e72 (MD5) Previous issue date: 2002http://dx.doi.org/10.1016/S0091-3057(02)00763-3reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBA5-HT2B/2C receptorsDrinking behaviorHypovolemiaHyperosmolarityFluid deprivationSerotoninmCPPCentral administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in ratsPharmacology Biochemistry and Behaviorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL1-s2.0-S0197245602002167-main.pdf1-s2.0-S0197245602002167-main.pdfapplication/pdf183560https://repositorio.ufba.br/bitstream/ri/7469/1/1-s2.0-S0197245602002167-main.pdfcf52579b2c114d28d3c3873ca0a37e72MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7469/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT1-s2.0-S0197245602002167-main.pdf.txt1-s2.0-S0197245602002167-main.pdf.txtExtracted texttext/plain43042https://repositorio.ufba.br/bitstream/ri/7469/3/1-s2.0-S0197245602002167-main.pdf.txtbfdbb4f84f31f3fda58246869ca3bcc1MD53ri/74692022-07-05 14:03:13.758oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats |
| dc.title.alternative.pt_BR.fl_str_mv |
Pharmacology Biochemistry and Behavior |
| title |
Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats |
| spellingShingle |
Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats Castro, L. 5-HT2B/2C receptors Drinking behavior Hypovolemia Hyperosmolarity Fluid deprivation Serotonin mCPP |
| title_short |
Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats |
| title_full |
Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats |
| title_fullStr |
Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats |
| title_full_unstemmed |
Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats |
| title_sort |
Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats |
| author |
Castro, L. |
| author_facet |
Castro, L. Maldonado, I. Campos, Igor Varjão, B. Angelo, Ana Luiza Dias Athanazio, Rodrigo Abensur Barbetta, Marcelo Campos Ramos, A. C. Fregoneze, Josmara Bartolomei Silva, E. de Castro e |
| author_role |
author |
| author2 |
Maldonado, I. Campos, Igor Varjão, B. Angelo, Ana Luiza Dias Athanazio, Rodrigo Abensur Barbetta, Marcelo Campos Ramos, A. C. Fregoneze, Josmara Bartolomei Silva, E. de Castro e |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Castro, L. Maldonado, I. Campos, Igor Varjão, B. Angelo, Ana Luiza Dias Athanazio, Rodrigo Abensur Barbetta, Marcelo Campos Ramos, A. C. Fregoneze, Josmara Bartolomei Silva, E. de Castro e Castro, L. Maldonado, I. Campos, Igor Varjão, B. Angelo, Ana Luiza Dias Athanazio, Rodrigo Abensur Barbetta, Marcelo Campos Ramos, A. C. Fregoneze, Josmara Bartolomei Silva, E. de Castro e |
| dc.subject.por.fl_str_mv |
5-HT2B/2C receptors Drinking behavior Hypovolemia Hyperosmolarity Fluid deprivation Serotonin mCPP |
| topic |
5-HT2B/2C receptors Drinking behavior Hypovolemia Hyperosmolarity Fluid deprivation Serotonin mCPP |
| description |
Texto completo: acesso restrito. p. 891-898 |
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2002 |
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2002 |
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2012-12-12T18:24:29Z |
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0091-3057 |
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v. 72, n. 4 |
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0091-3057 v. 72, n. 4 |
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