Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats

Detalhes bibliográficos
Autor(a) principal: Castro, L.
Data de Publicação: 2002
Outros Autores: Maldonado, I., Campos, Igor, Varjão, B., Angelo, Ana Luiza Dias, Athanazio, Rodrigo Abensur, Barbetta, Marcelo Campos, Ramos, A. C., Fregoneze, Josmara Bartolomei, Silva, E. de Castro e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7469
Resumo: Texto completo: acesso restrito. p. 891-898
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spelling Castro, L.Maldonado, I.Campos, IgorVarjão, B.Angelo, Ana Luiza DiasAthanazio, Rodrigo AbensurBarbetta, Marcelo CamposRamos, A. C.Fregoneze, Josmara BartolomeiSilva, E. de Castro eCastro, L.Maldonado, I.Campos, IgorVarjão, B.Angelo, Ana Luiza DiasAthanazio, Rodrigo AbensurBarbetta, Marcelo CamposRamos, A. C.Fregoneze, Josmara BartolomeiSilva, E. de Castro e2012-12-12T18:24:29Z20020091-3057http://www.repositorio.ufba.br/ri/handle/ri/7469v. 72, n. 4Texto completo: acesso restrito. p. 891-898In the present study, we investigated in rats the effect of third ventricle injections of 1-(3-chlorophenyl)piperazine (mCPP), a 5-HT2 receptor agonist, on water intake induced by three different physiological stimuli: fluid deprivation, acute salt load and hypovolemia. Injections of mCPP in the doses of 80 and 160 nmol/rat were able to decrease water intake in all three conditions studied. Third ventricle injections of mCPP (160 nmol/rat) were no longer able to diminish water intake in the groups of rats pretreated with central injections of an equimolar amount of (+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10 methylindolo[1,7-bc][2,6]-naphthyridine (SDZ SER 082), a selective 5-HT2B/2C antagonist. The central administration of mCPP (160 nmol/rat) was not able to modify the intake of a 0.1% saccharin solution. It is suggested that the central activation of a 5-HT2B/2C component is able to impair the drive for water intake induced by the physiological stimuli represented by fluid deprivation, acute salt load and hypovolemia. This effect seems not to be consequent on a general nonspecific central nervous system depression or on a locomotor deficit, because saccharin intake is not affected by third ventricle injections of mCPP.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2012-12-12T18:24:29Z No. of bitstreams: 1 1-s2.0-S0197245602002167-main.pdf: 183560 bytes, checksum: cf52579b2c114d28d3c3873ca0a37e72 (MD5)Made available in DSpace on 2012-12-12T18:24:29Z (GMT). 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dc.title.pt_BR.fl_str_mv Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats
dc.title.alternative.pt_BR.fl_str_mv Pharmacology Biochemistry and Behavior
title Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats
spellingShingle Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats
Castro, L.
5-HT2B/2C receptors
Drinking behavior
Hypovolemia
Hyperosmolarity
Fluid deprivation
Serotonin
mCPP
title_short Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats
title_full Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats
title_fullStr Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats
title_full_unstemmed Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats
title_sort Central administration of mCPP, a serotonin 5-HT2B/2C agonist, decreases water intake in rats
author Castro, L.
author_facet Castro, L.
Maldonado, I.
Campos, Igor
Varjão, B.
Angelo, Ana Luiza Dias
Athanazio, Rodrigo Abensur
Barbetta, Marcelo Campos
Ramos, A. C.
Fregoneze, Josmara Bartolomei
Silva, E. de Castro e
author_role author
author2 Maldonado, I.
Campos, Igor
Varjão, B.
Angelo, Ana Luiza Dias
Athanazio, Rodrigo Abensur
Barbetta, Marcelo Campos
Ramos, A. C.
Fregoneze, Josmara Bartolomei
Silva, E. de Castro e
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, L.
Maldonado, I.
Campos, Igor
Varjão, B.
Angelo, Ana Luiza Dias
Athanazio, Rodrigo Abensur
Barbetta, Marcelo Campos
Ramos, A. C.
Fregoneze, Josmara Bartolomei
Silva, E. de Castro e
Castro, L.
Maldonado, I.
Campos, Igor
Varjão, B.
Angelo, Ana Luiza Dias
Athanazio, Rodrigo Abensur
Barbetta, Marcelo Campos
Ramos, A. C.
Fregoneze, Josmara Bartolomei
Silva, E. de Castro e
dc.subject.por.fl_str_mv 5-HT2B/2C receptors
Drinking behavior
Hypovolemia
Hyperosmolarity
Fluid deprivation
Serotonin
mCPP
topic 5-HT2B/2C receptors
Drinking behavior
Hypovolemia
Hyperosmolarity
Fluid deprivation
Serotonin
mCPP
description Texto completo: acesso restrito. p. 891-898
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2012-12-12T18:24:29Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7469
dc.identifier.issn.none.fl_str_mv 0091-3057
dc.identifier.number.pt_BR.fl_str_mv v. 72, n. 4
identifier_str_mv 0091-3057
v. 72, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/7469
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