Guanylation of thiosemicarbazones: a new synthetic route to polysubstituted guanylhydrazones with antimicrobial activity
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/4959 |
Resumo: | p. 627-634. |
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Cunha, Silvio do DesterroMacedo Junior, Fernando César deCosta, Giselle A. NobreNeves, Daniela C.Souza Neta, Lourdes Cardoso deVencato, IvoSabino, José R.Lariucci, CarlitoCunha, Silvio do DesterroMacedo Junior, Fernando César deCosta, Giselle A. NobreNeves, Daniela C.Souza Neta, Lourdes Cardoso deVencato, IvoSabino, José R.Lariucci, Carlito2011-12-21T15:23:52Z2011-12-21T15:23:52Z20090103-5053http://www.repositorio.ufba.br/ri/handle/ri/4959v. 20, n. 4.p. 627-634.Guanil-hidrazonas poli-substituídas foram sintetizadas através da reação de guanilação de tiossemicarbazonas com aminas aromáticas e alifáticas, promovida HgCl2. Este método representa o primeiro emprego de tiossemicarbazonas como componente eletrofílico em reações de síntese de guanidinas mediadas por tiófilo, onde a introdução de cada substituinte dos nitrogênios das guanil-hidrazonas ocorreu de forma regiosseletiva. As atividades antibacteriana e antifúngica foram avaliadas e alguns derivados mostraram atividade em valores pequenos de concentração inibitória mínima e com amplo espectro de atividade. Estudou-se a estrutura cristalina de duas guanil-hidrazonas, determinando-se suas configurações e, as únicas interações relevantes observadas foram intermoleculares do tipo N-H...N e C-H...N.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2011-12-21T15:23:52Z No. of bitstreams: 1 v20n4a06.pdf: 1247918 bytes, checksum: 64ea12a53a1e11439c127e54a5c6ad40 (MD5)Made available in DSpace on 2011-12-21T15:23:52Z (GMT). No. of bitstreams: 1 v20n4a06.pdf: 1247918 bytes, checksum: 64ea12a53a1e11439c127e54a5c6ad40 (MD5) Previous issue date: 2009São Paulohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000400006&lng=en&nrm=isoreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAThiosemicarbazonesGuanylhydrazonesGuanidinesGuanylation of thiosemicarbazones: a new synthetic route to polysubstituted guanylhydrazones with antimicrobial activityJournal of the Brazilian Chemical Societyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALv20n4a06.pdfv20n4a06.pdfapplication/pdf1247918https://repositorio.ufba.br/bitstream/ri/4959/1/v20n4a06.pdf64ea12a53a1e11439c127e54a5c6ad40MD51LICENSElicense.txtlicense.txttext/plain1809https://repositorio.ufba.br/bitstream/ri/4959/2/license.txt8bb3e3eb871f5854a9ec419f68651b60MD52TEXTv20n4a06.pdf.txtv20n4a06.pdf.txtExtracted texttext/plain36972https://repositorio.ufba.br/bitstream/ri/4959/3/v20n4a06.pdf.txte056253f0bcd879719e2865934146625MD53ri/49592022-07-05 14:03:12.576oai:repositorio.ufba.br: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ório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:12Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Guanylation of thiosemicarbazones: a new synthetic route to polysubstituted guanylhydrazones with antimicrobial activity |
dc.title.alternative.pt_BR.fl_str_mv |
Journal of the Brazilian Chemical Society |
title |
Guanylation of thiosemicarbazones: a new synthetic route to polysubstituted guanylhydrazones with antimicrobial activity |
spellingShingle |
Guanylation of thiosemicarbazones: a new synthetic route to polysubstituted guanylhydrazones with antimicrobial activity Cunha, Silvio do Desterro Thiosemicarbazones Guanylhydrazones Guanidines |
title_short |
Guanylation of thiosemicarbazones: a new synthetic route to polysubstituted guanylhydrazones with antimicrobial activity |
title_full |
Guanylation of thiosemicarbazones: a new synthetic route to polysubstituted guanylhydrazones with antimicrobial activity |
title_fullStr |
Guanylation of thiosemicarbazones: a new synthetic route to polysubstituted guanylhydrazones with antimicrobial activity |
title_full_unstemmed |
Guanylation of thiosemicarbazones: a new synthetic route to polysubstituted guanylhydrazones with antimicrobial activity |
title_sort |
Guanylation of thiosemicarbazones: a new synthetic route to polysubstituted guanylhydrazones with antimicrobial activity |
author |
Cunha, Silvio do Desterro |
author_facet |
Cunha, Silvio do Desterro Macedo Junior, Fernando César de Costa, Giselle A. Nobre Neves, Daniela C. Souza Neta, Lourdes Cardoso de Vencato, Ivo Sabino, José R. Lariucci, Carlito |
author_role |
author |
author2 |
Macedo Junior, Fernando César de Costa, Giselle A. Nobre Neves, Daniela C. Souza Neta, Lourdes Cardoso de Vencato, Ivo Sabino, José R. Lariucci, Carlito |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Cunha, Silvio do Desterro Macedo Junior, Fernando César de Costa, Giselle A. Nobre Neves, Daniela C. Souza Neta, Lourdes Cardoso de Vencato, Ivo Sabino, José R. Lariucci, Carlito Cunha, Silvio do Desterro Macedo Junior, Fernando César de Costa, Giselle A. Nobre Neves, Daniela C. Souza Neta, Lourdes Cardoso de Vencato, Ivo Sabino, José R. Lariucci, Carlito |
dc.subject.por.fl_str_mv |
Thiosemicarbazones Guanylhydrazones Guanidines |
topic |
Thiosemicarbazones Guanylhydrazones Guanidines |
description |
p. 627-634. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2011-12-21T15:23:52Z |
dc.date.available.fl_str_mv |
2011-12-21T15:23:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/4959 |
dc.identifier.issn.none.fl_str_mv |
0103-5053 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 20, n. 4. |
identifier_str_mv |
0103-5053 v. 20, n. 4. |
url |
http://www.repositorio.ufba.br/ri/handle/ri/4959 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000400006&lng=en&nrm=iso |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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UFBA |
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Repositório Institucional da UFBA |
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