Dengue hemorrhagic fever is associated with polymorphisms in JAK1
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12161 |
Resumo: | Texto completo: acesso restrito. p.1221-1227 |
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Silva, Luciano K.Blanton, Ronald EdwardParrado, Antonio R.Melo, Paulo S.Morato, Vanessa G.Reis, Eliana A. G.Dias, Juarez PereiraCastro, Jesuina M.Barreto, Mauricio LimaReis, Mitermayer Galvão dosTeixeira, Maria da Glória Lima CruzSilva, Luciano K.Blanton, Ronald EdwardParrado, Antonio R.Melo, Paulo S.Morato, Vanessa G.Reis, Eliana A. G.Dias, Juarez PereiraCastro, Jesuina M.Barreto, Mauricio LimaReis, Mitermayer Galvão dosTeixeira, Maria da Glória Lima Cruz2013-07-10T13:19:25Z20101018-4813http://www.repositorio.ufba.br/ri/handle/ri/12161v. 18, n. 11Texto completo: acesso restrito. p.1221-1227To identify genes associated with the clinical presentation of dengue, 50 cases of probable or possible dengue hemorrhagic fever (DHF), 236 dengue fever (DF), and 236 asymptomatic infections were genotyped for 593 single-nucleotide polymorphisms (SNPs) in 56 genes across the type 1 interferon (IFN) response pathway as well as other important candidate genes. By single locus analysis comparing DHF with DF, 11 of the 51 markers with P<0.05 were in the JAK1 gene. Five markers were significantly associated by false discovery rate criteria (q<0.20 when P<6 × 10−4). The JAK1 SNPs showed differential distribution by ethnicity and ancestry consistent with epidemiologic observations in the Americas. The association remained significant after controlling for ancestry and income. No association was observed with markers in the gene encoding CD209 (DC-SIGN). An association between DHF and JAK1 polymorphisms is in agreement with expression profiles showing generalized decreased type 1 IFN-stimulated gene expression in these patients.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-07-10T13:19:25Z No. of bitstreams: 1 ejhg201098a.pdf: 456193 bytes, checksum: a35329e4daaa7af5ef15b23b878c4c1e (MD5)Made available in DSpace on 2013-07-10T13:19:25Z (GMT). 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| dc.title.pt_BR.fl_str_mv |
Dengue hemorrhagic fever is associated with polymorphisms in JAK1 |
| dc.title.alternative.pt_BR.fl_str_mv |
European Journal of Human Genetics |
| title |
Dengue hemorrhagic fever is associated with polymorphisms in JAK1 |
| spellingShingle |
Dengue hemorrhagic fever is associated with polymorphisms in JAK1 Silva, Luciano K. Flavivirus Population structure Interferon Genetic association Brazil |
| title_short |
Dengue hemorrhagic fever is associated with polymorphisms in JAK1 |
| title_full |
Dengue hemorrhagic fever is associated with polymorphisms in JAK1 |
| title_fullStr |
Dengue hemorrhagic fever is associated with polymorphisms in JAK1 |
| title_full_unstemmed |
Dengue hemorrhagic fever is associated with polymorphisms in JAK1 |
| title_sort |
Dengue hemorrhagic fever is associated with polymorphisms in JAK1 |
| author |
Silva, Luciano K. |
| author_facet |
Silva, Luciano K. Blanton, Ronald Edward Parrado, Antonio R. Melo, Paulo S. Morato, Vanessa G. Reis, Eliana A. G. Dias, Juarez Pereira Castro, Jesuina M. Barreto, Mauricio Lima Reis, Mitermayer Galvão dos Teixeira, Maria da Glória Lima Cruz |
| author_role |
author |
| author2 |
Blanton, Ronald Edward Parrado, Antonio R. Melo, Paulo S. Morato, Vanessa G. Reis, Eliana A. G. Dias, Juarez Pereira Castro, Jesuina M. Barreto, Mauricio Lima Reis, Mitermayer Galvão dos Teixeira, Maria da Glória Lima Cruz |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Luciano K. Blanton, Ronald Edward Parrado, Antonio R. Melo, Paulo S. Morato, Vanessa G. Reis, Eliana A. G. Dias, Juarez Pereira Castro, Jesuina M. Barreto, Mauricio Lima Reis, Mitermayer Galvão dos Teixeira, Maria da Glória Lima Cruz Silva, Luciano K. Blanton, Ronald Edward Parrado, Antonio R. Melo, Paulo S. Morato, Vanessa G. Reis, Eliana A. G. Dias, Juarez Pereira Castro, Jesuina M. Barreto, Mauricio Lima Reis, Mitermayer Galvão dos Teixeira, Maria da Glória Lima Cruz |
| dc.subject.por.fl_str_mv |
Flavivirus Population structure Interferon Genetic association Brazil |
| topic |
Flavivirus Population structure Interferon Genetic association Brazil |
| description |
Texto completo: acesso restrito. p.1221-1227 |
| publishDate |
2010 |
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2010 |
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2013-07-10T13:19:25Z |
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1018-4813 |
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v. 18, n. 11 |
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1018-4813 v. 18, n. 11 |
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http://www.repositorio.ufba.br/ri/handle/ri/12161 |
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