Phylogenetic analysis of G1P[6] group A rotavirus strains detected in Northeast Brazilian children fully vaccinated with Rotarix
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14870 |
Resumo: | Texto completo: acesso restrito. p. 395–402 |
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Gómez, Mariela MartínezSilva, Marcelle Figueira Marques daZeller, MarkHeylen, ElisabethMatthijnssens, JelleIchihara, Maria Yuri TravassosRose, Tatiana LundgrenVolotão, Eduardo de MelloLeite, José Paulo GagliardiGómez, Mariela MartínezSilva, Marcelle Figueira Marques daZeller, MarkHeylen, ElisabethMatthijnssens, JelleIchihara, Maria Yuri TravassosRose, Tatiana LundgrenVolotão, Eduardo de MelloLeite, José Paulo Gagliardi2014-04-24T15:39:58Z20131567-1348http://repositorio.ufba.br/ri/handle/ri/14870v. 19Texto completo: acesso restrito. p. 395–402In 2009 the World Health Organization recommended the use of group A rotavirus (RVA) vaccines in all national immunization programs (NIPs) in order to control severe RVA gastroenteritis disease. In Brazil, Rotarix™ was introduced in the NIP in March 2006, and a significant reduction in mortality rates among children ⩽5 years old was observed, especially in the Northern and Northeastern Brazil. In the current study the 11 gene segments of six Brazilian G1P[6] RVA strains, isolated in 2009 and 2010 from vaccinated children, were analyzed in order to investigate if the genetic composition of these strains might help to elucidate why they were able to cause acute gastroenteritis in vaccinated children. All six Brazilian RVA strains revealed a complete Wa-like genotype constellation: G1-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1. Phylogenetic analysis showed that all six strains were nearly identical and showed a close genetic relationship with contemporary typical human Wa-like RVA strains. These results suggests that the fact that these strains were able to cause acute gastroenteritis in vaccinated children is likely not due to the genetic background of the strains, but rather to other factors such as host relating factors, co-infecting pathogens or vaccine efficacy. P[6] RVA strains are detected rather occasionally in humans in most regions of the world, except for South Asia and Sub-Saharan Africa. However, recently two studies conducted in Brazil showed the circulation of G12P[6] and G2P[6]. This is the first report on the detection and complete genome analyses of G1P[6] RVA strains in Brazil. Surveillance studies will be crucial to further investigate the prevalence of this genotype in the Brazilian population, and the efficacy of current licensed vaccines, which do not contain the P[6] genotype.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-24T15:39:58Z No. of bitstreams: 1 1-s2.0-S1567134813001019-main.pdf: 2506822 bytes, checksum: 6290afddc1241176411651ac225920d0 (MD5)Made available in DSpace on 2014-04-24T15:39:58Z (GMT). No. of bitstreams: 1 1-s2.0-S1567134813001019-main.pdf: 2506822 bytes, checksum: 6290afddc1241176411651ac225920d0 (MD5) Previous issue date: 2013http://dx.doi.org/10.1016/j.meegid.2013.03.028reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAGroup A rotavirusG1P[6]Rotarix™Phylogenetic analysisComplete genome analysisPhylogenetic analysis of G1P[6] group A rotavirus strains detected in Northeast Brazilian children fully vaccinated with RotarixInfection, Genetics and Evolutioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14870/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINAL1-s2.0-S1567134813001019-main.pdf1-s2.0-S1567134813001019-main.pdfapplication/pdf2506822https://repositorio.ufba.br/bitstream/ri/14870/1/1-s2.0-S1567134813001019-main.pdf6290afddc1241176411651ac225920d0MD51TEXT1-s2.0-S1567134813001019-main.pdf.txt1-s2.0-S1567134813001019-main.pdf.txtExtracted texttext/plain45681https://repositorio.ufba.br/bitstream/ri/14870/3/1-s2.0-S1567134813001019-main.pdf.txt9d5cdab8f8c3155a6ed690197af8470aMD53ri/148702022-07-05 14:03:52.26oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:52Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Phylogenetic analysis of G1P[6] group A rotavirus strains detected in Northeast Brazilian children fully vaccinated with Rotarix |
| dc.title.alternative.pt_BR.fl_str_mv |
Infection, Genetics and Evolution |
| title |
Phylogenetic analysis of G1P[6] group A rotavirus strains detected in Northeast Brazilian children fully vaccinated with Rotarix |
| spellingShingle |
Phylogenetic analysis of G1P[6] group A rotavirus strains detected in Northeast Brazilian children fully vaccinated with Rotarix Gómez, Mariela Martínez Group A rotavirus G1P[6] Rotarix™ Phylogenetic analysis Complete genome analysis |
| title_short |
Phylogenetic analysis of G1P[6] group A rotavirus strains detected in Northeast Brazilian children fully vaccinated with Rotarix |
| title_full |
Phylogenetic analysis of G1P[6] group A rotavirus strains detected in Northeast Brazilian children fully vaccinated with Rotarix |
| title_fullStr |
Phylogenetic analysis of G1P[6] group A rotavirus strains detected in Northeast Brazilian children fully vaccinated with Rotarix |
| title_full_unstemmed |
Phylogenetic analysis of G1P[6] group A rotavirus strains detected in Northeast Brazilian children fully vaccinated with Rotarix |
| title_sort |
Phylogenetic analysis of G1P[6] group A rotavirus strains detected in Northeast Brazilian children fully vaccinated with Rotarix |
| author |
Gómez, Mariela Martínez |
| author_facet |
Gómez, Mariela Martínez Silva, Marcelle Figueira Marques da Zeller, Mark Heylen, Elisabeth Matthijnssens, Jelle Ichihara, Maria Yuri Travassos Rose, Tatiana Lundgren Volotão, Eduardo de Mello Leite, José Paulo Gagliardi |
| author_role |
author |
| author2 |
Silva, Marcelle Figueira Marques da Zeller, Mark Heylen, Elisabeth Matthijnssens, Jelle Ichihara, Maria Yuri Travassos Rose, Tatiana Lundgren Volotão, Eduardo de Mello Leite, José Paulo Gagliardi |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gómez, Mariela Martínez Silva, Marcelle Figueira Marques da Zeller, Mark Heylen, Elisabeth Matthijnssens, Jelle Ichihara, Maria Yuri Travassos Rose, Tatiana Lundgren Volotão, Eduardo de Mello Leite, José Paulo Gagliardi Gómez, Mariela Martínez Silva, Marcelle Figueira Marques da Zeller, Mark Heylen, Elisabeth Matthijnssens, Jelle Ichihara, Maria Yuri Travassos Rose, Tatiana Lundgren Volotão, Eduardo de Mello Leite, José Paulo Gagliardi |
| dc.subject.por.fl_str_mv |
Group A rotavirus G1P[6] Rotarix™ Phylogenetic analysis Complete genome analysis |
| topic |
Group A rotavirus G1P[6] Rotarix™ Phylogenetic analysis Complete genome analysis |
| description |
Texto completo: acesso restrito. p. 395–402 |
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2013 |
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2013 |
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2014-04-24T15:39:58Z |
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1567-1348 |
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v. 19 |
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